OGATA Kazuhiro

J-GLOBAL         Last updated: Jan 7, 2020 at 18:39
 
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Name
OGATA Kazuhiro
Affiliation
Yokohama City University
Section
School of Medicine, Medical Course, Biochemistry, Medical Studies
Job title
Professor

Research Areas

 

Published Papers

 
Hashiguchi S, Doi H, Kunii M, Nakamura Y, Shimuta M, Suzuki E, Koyano S, Okubo M, Kishida H, Shiina M, Ogata K, Hirashima F, Inoue Y, Kubota S, Hayashi N, Nakamura H, Takahashi K, Katsumoto A, Tada M, Tanaka K, Sasaoka T, Miyatake S, Miyake N, Saitsu H, Sato N, Ozaki K, Ohta K, Yokota T, Mizusawa H, Mitsui J, Ishiura H, Yoshimura J, Morishita S, Tsuji S, Takeuchi H, Ishikawa K, Matsumoto N, Ishikawa T, Tanaka F
Neurobiology of disease   130 104516   Oct 2019   [Refereed]
Nakashima M, Ogata K, Saitsu H, Matsumoto N
Annals of neurology      Sep 2019   [Refereed]
Iwama K, Mizuguchi T, Takeshita E, Nakagawa E, Okazaki T, Nomura Y, Iijima Y, Kajiura I, Sugai K, Saito T, Sasaki M, Yuge K, Saikusa T, Okamoto N, Takahashi S, Amamoto M, Tomita I, Kumada S, Anzai Y, Hoshino K, Fattal-Valevski A, Shiroma N, Ohfu M, Moroto M, Tanda K, Nakagawa T, Sakakibara T, Nabatame S, Matsuo M, Yamamoto A, Yukishita S, Inoue K, Waga C, Nakamura Y, Watanabe S, Ohba C, Sengoku T, Fujita A, Mitsuhashi S, Miyatake S, Takata A, Miyake N, Ogata K, Ito S, Saitsu H, Matsuishi T, Goto YI, Matsumoto N
Journal of medical genetics   56(6) 396-407   Jun 2019   [Refereed]
Miyado M, Fukami M, Takada S, Terao M, Nakabayashi K, Hata K, Matsubara Y, Tanaka Y, Sasaki G, Nagasaki K, Shiina M, Ogata K, Masunaga Y, Saitsu H, Ogata T
Journal of the American Society of Nephrology : JASN   30(5) 877-889   May 2019   [Refereed]
Tsuchida N, Hamada K, Shiina M, Kato M, Kobayashi Y, Tohyama J, Kimura K, Hoshino K, Ganesan V, Teik KW, Nakashima M, Mitsuhashi S, Mizuguchi T, Takata A, Miyake N, Saitsu H, Ogata K, Miyatake S, Matsumoto N
Clinical genetics   94(6) 538-547   Dec 2018   [Refereed]
Miyatake S, Schneeberger S, Koyama N, Yokochi K, Ohmura K, Shiina M, Mori H, Koshimizu E, Imagawa E, Uchiyama Y, Mitsuhashi S, Frith MC, Fujita A, Satoh M, Taguri M, Tomono Y, Takahashi K, Doi H, Takeuchi H, Nakashima M, Mizuguchi T, Takata A, Miyake N, Saitsu H, Tanaka F, Ogata K, Hennet T, Matsumoto N
Annals of neurology   84(6) 843-853   Dec 2018   [Refereed]
Fujita A, Tsukaguchi H, Koshimizu E, Nakazato H, Itoh K, Kuraoka S, Komohara Y, Shiina M, Nakamura S, Kitajima M, Tsurusaki Y, Miyatake S, Ogata K, Iijima K, Matsumoto N, Miyake N
Annals of neurology   84(6) 814-828   Dec 2018   [Refereed]
Uchiyama Y, Yanagisawa K, Kunishima S, Shiina M, Ogawa Y, Nakashima M, Hirato J, Imagawa E, Fujita A, Hamanaka K, Miyatake S, Mitsuhashi S, Takata A, Miyake N, Ogata K, Handa H, Matsumoto N, Mizuguchi T
Clinical genetics      Jul 2018   [Refereed]
Fassio A, Esposito A, Kato M, Saitsu H, Mei D, Marini C, Conti V, Nakashima M, Okamoto N, Olmez Turker A, Albuz B, Semerci Gündüz CN, Yanagihara K, Belmonte E, Maragliano L, Ramsey K, Balak C, Siniard A, Narayanan V, C4RCD Research Group., Ohba C, Shiina M, Ogata K, Matsumoto N, Benfenati F, Guerrini R
Brain : a journal of neurology   141(6) 1703-1718   Jun 2018   [Refereed]
Uchiyama Y, Ogawa Y, Kunishima S, Shiina M, Nakashima M, Yanagisawa K, Yokohama A, Imagawa E, Miyatake S, Mizuguchi T, Takata A, Miyake N, Ogata K, Handa H, Matsumoto N
British journal of haematology   181(6) 843-847   Jun 2018   [Refereed]
Nakashima M, Kato M, Aoto K, Shiina M, Belal H, Mukaida S, Kumada S, Sato A, Zerem A, Lerman-Sagie T, Lev D, Leong HY, Tsurusaki Y, Mizuguchi T, Miyatake S, Miyake N, Ogata K, Saitsu H, Matsumoto N
Annals of neurology   83(4) 794-806   Apr 2018   [Refereed]
Suzuki T, Behnam M, Ronasian F, Salehi M, Shiina M, Koshimizu E, Fujita A, Sekiguchi F, Miyatake S, Mizuguchi T, Nakashima M, Ogata K, Takeda S, Matsumoto N, Miyake N
Journal of human genetics   63(4) 425-430   Apr 2018   [Refereed]
Mizuguchi T, Nakashima M, Kato M, Okamoto N, Kurahashi H, Ekhilevitch N, Shiina M, Nishimura G, Shibata T, Matsuo M, Ikeda T, Ogata K, Tsuchida N, Mitsuhashi S, Miyatake S, Takata A, Miyake N, Hata K, Kaname T, Matsubara Y, Saitsu H, Matsumoto N
Human molecular genetics   27(8) 1421-1433   Apr 2018   [Refereed]
Akita T, Aoto K, Kato M, Shiina M, Mutoh H, Nakashima M, Kuki I, Okazaki S, Magara S, Shiihara T, Yokochi K, Aiba K, Tohyama J, Ohba C, Miyatake S, Miyake N, Ogata K, Fukuda A, Matsumoto N, Saitsu H
Annals of clinical and translational neurology   5(3) 280-296   Mar 2018   [Refereed]
Cho K, Yamada M, Agematsu K, Kanegane H, Miyake N, Ueki M, Akimoto T, Kobayashi N, Ikemoto S, Tanino M, Fujita A, Hayasaka I, Miyamoto S, Tanaka-Kubota M, Nakata K, Shiina M, Ogata K, Minakami H, Matsumoto N, Ariga T
American journal of human genetics   102(3) 480-486   Mar 2018   [Refereed]
Kasahara K, Shiina M, Higo J, Ogata K, Nakamura H
Nucleic acids research   46(5) 2243-2251   Mar 2018   [Refereed]
Iwama K, Iwata A, Shiina M, Mitsuhashi S, Miyatake S, Takata A, Miyake N, Ogata K, Ito S, Mizuguchi T, Matsumoto N
Journal of human genetics   63(2) 207-211   Feb 2018   [Refereed]
Mizuguchi T, Nakashima M, Kato M, Yamada K, Okanishi T, Ekhilevitch N, Mandel H, Eran A, Toyono M, Sawaishi Y, Motoi H, Shiina M, Ogata K, Miyatake S, Miyake N, Saitsu H, Matsumoto N
Journal of human genetics   62(5) 587   Apr 2017   [Refereed]
Mizuguchi T, Nakashima M, Kato M, Yamada K, Okanishi T, Ekhilevitch N, Mandel H, Eran A, Toyono M, Sawaishi Y, Motoi H, Shiina M, Ogata K, Miyatake S, Miyake N, Saitsu H, Matsumoto N
Journal of human genetics   62(5) 525-529   Apr 2017   [Refereed]
Lardelli RM, Schaffer AE, Eggens VR, Zaki MS, Grainger S, Sathe S, Van Nostrand EL, Schlachetzki Z, Rosti B, Akizu N, Scott E, Silhavy JL, Heckman LD, Rosti RO, Dikoglu E, Gregor A, Guemez-Gamboa A, Musaev D, Mande R, Widjaja A, Shaw TL, Markmiller S, Marin-Valencia I, Davies JH, de Meirleir L, Kayserili H, Altunoglu U, Freckmann ML, Warwick L, Chitayat D, Blaser S, Çağlayan AO, Bilguvar K, Per H, Fagerberg C, Christesen HT, Kibaek M, Aldinger KA, Manchester D, Matsumoto N, Muramatsu K, Saitsu H, Shiina M, Ogata K, Foulds N, Dobyns WB, Chi NC, Traver D, Spaccini L, Bova SM, Gabriel SB, Gunel M, Valente EM, Nassogne MC, Bennett EJ, Yeo GW, Baas F, Lykke-Andersen J, Gleeson JG
Nature genetics   49(3) 457-464   Mar 2017   [Refereed]
Miyatake S, Mitsuhashi S, Hayashi YK, Purevjav E, Nishikawa A, Koshimizu E, Suzuki M, Yatabe K, Tanaka Y, Ogata K, Kuru S, Shiina M, Tsurusaki Y, Nakashima M, Mizuguchi T, Miyake N, Saitsu H, Ogata K, Kawai M, Towbin J, Nonaka I, Nishino I, Matsumoto N
American journal of human genetics   100(1) 169-178   Jan 2017   [Refereed]
Kasahara K, Shiina M, Fukuda I, Ogata K, Nakamura H
PloS one   12(2) e0172654   2017   [Refereed]
Miyake N, Fukai R, Ohba C, Chihara T, Miura M, Shimizu H, Kakita A, Imagawa E, Shiina M, Ogata K, Okuno-Yuguchi J, Fueki N, Ogiso Y, Suzumura H, Watabe Y, Imataka G, Leong HY, Fattal-Valevski A, Kramer U, Miyatake S, Kato M, Okamoto N, Sato Y, Mitsuhashi S, Nishino I, Kaneko N, Nishiyama A, Tamura T, Mizuguchi T, Nakashima M, Tanaka F, Saitsu H, Matsumoto N
American journal of human genetics   99(4) 950-961   Oct 2016   [Refereed]
Čulić V, Miyake N, Janković S, Petrović D, Šimunović M, Đapić T, Shiina M, Ogata K, Matsumoto N
Human genome variation   3 16035   Oct 2016   [Refereed]
Yamamoto T, Endo W, Ohnishi H, Kubota K, Kawamoto N, Inui T, Imamura A, Takanashi JI, Shiina M, Saitsu H, Ogata K, Matsumoto N, Haginoya K, Fukao T
Brain & development   39(3) 236-242   Oct 2016   [Refereed]
Saitsu H, Fukai R, Ben-Zeev B, Sakai Y, Mimaki M, Okamoto N, Suzuki Y, Monden Y, Saito H, Tziperman B, Torio M, Akamine S, Takahashi N, Osaka H, Yamagata T, Nakamura K, Tsurusaki Y, Nakashima M, Miyake N, Shiina M, Ogata K, Matsumoto N
European Journal of Human Genetics : EJHG   24(1) 129-134   Jan 2016   [Refereed]
Imai N, Miyake N, Saito Y, Kobayashi E, Ikawa M, Manaka S, Shiina M, Ogata K, Matsumoto N
The Journal of Headache and Pain   16(1) 519   Dec 2015   [Refereed]
Nakashima M, Kouga T, Lourenço CM, Shiina M, Goto T, Tsurusaki Y, Miyatake S, Miyake N, Saitsu H, Ogata K, Osaka H, Matsumoto N
Epilepsia   57(1) e18-23   Nov 2015   [Refereed]
Miyake N, Tsukaguchi H, Koshimizu E, Shono A, Matsunaga S, Shiina M, Mimura Y, Imamura S, Hirose T, Okudela K, Nozu K, Akioka Y, Hattori M, Yoshikawa N, Kitamura A, Cheong HI, Kagami S, Yamashita M, Fujita A, Miyatake S, Tsurusaki Y, Nakashima M, Saitsu H, Ohashi K, Imamoto N, Ryo A, Ogata K, Iijima K, Matsumoto N
American Journal of Human Genetics   97(4) 555-566   Oct 2015   [Refereed]
Tsurusaki Y, Tanaka R, Shimada S, Shimojima K, Shiina M, Nakashima M, Saitsu H, Miyake N, Ogata K, Yamamoto T, Matsumoto N
Journal of Human Genetics   60(10) 631-635   Oct 2015   [Refereed]
Nakashima M, Saitsu H, Takei N, Tohyama J, Kato M, Kitaura H, Shiina M, Shirozu H, Masuda H, Watanabe K, Ohba C, Tsurusaki Y, Miyake N, Zheng Y, Sato T, Takebayashi H, Ogata K, Kameyama S, Kakita A, Matsumoto N
Annals of Neurology   78(3) 375-386   Sep 2015   [Refereed]
Ohba C, Shiina M, Tohyama J, Haginoya K, Lerman-Sagie T, Okamoto N, Blumkin L, Lev D, Mukaida S, Nozaki F, Uematsu M, Onuma A, Kodera H, Nakashima M, Tsurusaki Y, Miyake N, Tanaka F, Kato M, Ogata K, Saitsu H, Matsumoto N
Epilepsia   56(6) 841-848   Jun 2015   [Refereed]
Shiina M, Hamada K, Inoue-Bungo T, Shimamura M, Uchiyama A, Baba S, Sato K, Yamamoto M, Ogata K
Journal of Molecular Biology   427(8) 1655-1669   Apr 2015   [Refereed]
Ogura Y, Miyake N, Kou I, Iida A, Nakajima M, Takeda K, Fujibayashi S, Shiina M, Okada E, Toyama Y, Iwanami A, Ishii K, Ogata K, Asahara H, Matsumoto N, Nakamura M, Matsumoto M, Ikegawa S
PLoS One   10(11) e0142126   2015   [Refereed]
Doi H, Ushiyama M, Baba T, Tani K, Shiina M, Ogata K, Miyatake S, Fukuda-Yuzawa Y, Tsuji S, Nakashima M, Tsurusaki Y, Miyake N, Saitsu H, Ikeda S, Tanaka F, Matsumoto N, Yoshida K
Scientific Reports   4 7132   Nov 2014   [Refereed]
Shiina M, Hamada K, Inoue-Bungo T, Shimamura M, Baba S, Sato K, Ogata K
Acta crystallographica. Section F, Structural biology communications   70(Pt 10) 1380-1384   Oct 2014   [Refereed]
Miyatake S, Koshimizu E, Hayashi YK, Miya K, Shiina M, Nakashima M, Tsurusaki Y, Miyake N, Saitsu H, Ogata K, Nishino I, Matsumoto N
Neuromuscular disorders : NMD   24(7) 642-647   Jul 2014   [Refereed]
Tsurusaki Y, Koshimizu E, Ohashi H, Phadke S, Kou I, Shiina M, Suzuki T, Okamoto N, Imamura S, Yamashita M, Watanabe S, Yoshiura K, Kodera H, Miyatake S, Nakashima M, Saitsu H, Ogata K, Ikegawa S, Miyake N, Matsumoto N
Nature Communications   5 4011   Jun 2014   [Refereed]
Miyatake S, Osaka H, Shiina M, Sasaki M, Takanashi J, Haginoya K, Wada T, Morimoto M, Ando N, Ikuta Y, Nakashima M, Tsurusaki Y, Miyake N, Ogata K, Matsumoto N, Saitsu H
Neurology   82(24) 2230-2237   Jun 2014   [Refereed]
Imagawa E, Osaka H, Yamashita A, Shiina M, Takahashi E, Sugie H, Nakashima M, Tsurusaki Y, Saitsu H, Ogata K, Matsumoto N, Miyake N
Human Genetics   133(2) 225-234   Feb 2014   [Refereed]
Gupta VA, Ravenscroft G, Shaheen R, Todd EJ, Swanson LC, Shiina M, Ogata K, Hsu C, Clarke NF, Darras BT, Farrar MA, Hashem A, Manton ND, Muntoni F, North KN, Sandaradura SA, Nishino I, Hayashi YK, Sewry CA, Thompson EM, Yau KS, Brownstein CA, Yu TW, Allcock RJ, Davis MR, Wallgren-Pettersson C, Matsumoto N, Alkuraya FS, Laing NG, Beggs AH
American Journal of Human Genetics   93(6) 1108-1117   Dec 2013   [Refereed]
Nakamura K, Kodera H, Akita T, Shiina M, Kato M, Hoshino H, Terashima H, Osaka H, Nakamura S, Tohyama J, Kumada T, Furukawa T, Iwata S, Shiihara T, Kubota M, Miyatake S, Koshimizu E, Nishiyama K, Nakashima M, Tsurusaki Y, Miyake N, Hayasaka K, Ogata K, Fukuda A, Matsumoto N, Saitsu H
American Journal of Human genetics   93(3) 496-505   Sep 2013   [Refereed]
Ravenscroft G, Miyatake S, Lehtokari VL, Todd EJ, Vornanen P, Yau KS, Hayashi YK, Miyake N, Tsurusaki Y, Doi H, Saitsu H, Osaka H, Yamashita S, Ohya T, Sakamoto Y, Koshimizu E, Imamura S, Yamashita M, Ogata K, Shiina M, Bryson-Richardson RJ, Vaz R, Ceyhan O, Brownstein CA, Swanson LC, Monnot S, Romero NB, Amthor H, Kresoje N, Sivadorai P, Kiraly-Borri C, Haliloglu G, Talim B, Orhan D, Kale G, Charles AK, Fabian VA, Davis MR, Lammens M, Sewry CA, Manzur A, Muntoni F, Clarke NF, North KN, Bertini E, Nevo Y, Willichowski E, Silberg IE, Topaloglu H, Beggs AH, Allcock RJ, Nishino I, Wallgren-Pettersson C, Matsumoto N, Laing NG
American Journal of Human Genetics   93(1) 6-18   Jul 2013   [Refereed]
Iida A, Okamoto N, Miyake N, Nishimura G, Minami S, Sugimoto T, Nakashima M, Tsurusaki Y, Saitsu H, Shiina M, Ogata K, Watanabe S, Ohashi H, Matsumoto N, Ikegawa S
Journal of Human Genetics   58(6) 391-394   Jun 2013   [Refereed]
Miyake N, Yano S, Sakai C, Hatakeyama H, Matsushima Y, Shiina M, Watanabe Y, Bartley J, Abdenur JE, Wang RY, Chang R, Tsurusaki Y, Doi H, Nakashima M, Saitsu H, Ogata K, Goto Y, Matsumoto N
Human Mutation   34(3) 446-452   Mar 2013   [Refereed]
Miyake N, Mizuno S, Okamoto N, Ohashi H, Shiina M, Ogata K, Tsurusaki Y, Nakashima M, Saitsu H, Niikawa N, Matsumoto N
Human Mutation   34(1) 108-110   Jan 2013   [Refereed]
Ogura Y, Yabuki S, Iida A, Kou I, Nakajima M, Kano H, Shiina M, Kikuchi S, Toyama Y, Ogata K, Nakamura M, Matsumoto M, Ikegawa S
PloS one   8(11) e80548   2013   [Refereed]
Tsurusaki Y, Okamoto N, Ohashi H, Kosho T, Imai Y, Hibi-Ko Y, Kaname T, Naritomi K, Kawame H, Wakui K, Fukushima Y, Homma T, Kato M, Hiraki Y, Yamagata T, Yano S, Mizuno S, Sakazume S, Ishii T, Nagai T, Shiina M, Ogata K, Ohta T, Niikawa N, Miyatake S, Okada I, Mizuguchi T, Doi H, Saitsu H, Miyake N, Matsumoto N
Nature Genetics   44(4) 376-378   Mar 2012   [Refereed]
Yoneda Y, Saitsu H, Touyama M, Makita Y, Miyamoto A, Hamada K, Kurotaki N, Tomita H, Nishiyama K, Tsurusaki Y, Doi H, Miyake N, Ogata K, Naritomi K, Matsumoto N
Journal of Human Genetics   57(3) 207-211   Mar 2012   [Refereed]
Saitsu H, Osaka H, Sasaki M, Takanashi J, Hamada K, Yamashita A, Shibayama H, Shiina M, Kondo Y, Nishiyama K, Tsurusaki Y, Miyake N, Doi H, Ogata K, Inoue K, Matsumoto N
American Journal of Human Genetics   89(5) 644-651   Nov 2011   [Refereed]
Jounai N, Kobiyama K, Shiina M, Ogata K, Ishii KJ, Takeshita F
Journal of immunology (Baltimore, Md. : 1950)   186(3) 1646-1655   Feb 2011   [Refereed]
Theeraladanon C, Takahashi N, Shiina M, Hamada K, Takada Y, Endo H, Tateishi U, Oka T, Ogata K, Inoue T
Cancer biotherapy & radiopharmaceuticals   25(4) 479-485   Aug 2010   [Refereed]
Babayeva ND, Wilder PJ, Shiina M, Mino K, Desler M, Ogata K, Rizzino A, Tahirov TH
Cell Cycle   9(14) 3054-3062   Aug 2010
Ets1 is a member of the Ets family of transcription factors. Ets1 is autoinhibited and its activation requires heterodimerization with a partner protein or DNA-mediated homodimerization for cooperative DNA binding. In the latter case, Ets1 molecul...
Saitsu H, Tohyama J, Kumada T, Egawa K, Hamada K, Okada I, Mizuguchi T, Osaka H, Miyata R, Furukawa T, Haginoya K, Hoshino H, Goto T, Hachiya Y, Yamagata T, Saitoh S, Nagai T, Nishiyama K, Nishimura A, Miyake N, Komada M, Hayashi K, Hirai S, Ogata K, Kato M, Fukuda A, Matsumoto N
Am J Hum Genet   86(6) 881-891   Jul 2010
A de novo 9q33.3-q34.11 microdeletion involving STXBP1 has been found in one of four individuals (group A) with early-onset West syndrome, severe hypomyelination, poor visual attention, and developmental delay. Although haploinsufficiency of STXBP...
Yamashita K, Suzuki A, Satoh Y, Ide M, Amano Y, Masuda-Hirata M, Hayashi YK, Hamada K, Ogata K, Ohno S
Biochemical and biophysical research communications   391(1) 812-817   Jan 2010   [Refereed]
Saitsu H, Kato M, Mizuguchi T, Hamada K, Osaka H, Tohyama J, Uruno K, Kumada S, Nishiyama K, Nishimura A, Okada I, Yoshimura Y, Hirai S, Kumada T, Hayasaka K, Fukuda A, Ogata K, Matsumoto N
Nature Genetics   40(6) 782-788   Jun 2008   [Refereed]
Sekine K, Chen YR, Kojima N, Ogata K, Fukamizu A, Miyajima A
The EMBO Journal   26(15) 3607-3615   Aug 2007   [Refereed]
Morita T, Yamashita A, Kashima I, Ogata K, Ishiura S, Ohno S
J Biol Chem   282(11) 7799-7808   Mar 2007   [Refereed]
Watanabe N, Arai H, Iwasaki J, Shiina M, Ogata K, Hunter T, Osada H
Proceedings of the National Academy of Sciences of the United States of America   102(33) 11663-11668   Aug 2005   [Refereed]
Biochemistry and structural biology in the postgenome era: Search for the underlying mechanisms of biological molecules
Ogata K
Seikagaku   76(10) 1305-1319   2004
Ogata K, Sato K, Tahirov TH
Current opinion in structural biology   13(1) 40-48   Feb 2003   [Refereed]
Tahirov TH, Sato K, Ichikawa-Iwata E, Sasaki M, Inoue-Bungo T, Shiina M, Kimura K, Takata S, Fujikawa A, Morii H, Kumasaka T, Yamamoto M, Ishii S, Ogata K
Cell   108(1) 57-70   Jan 2002   [Refereed]
T. H. Tahirov, M. Sasaki, T. Inoue-Bungo, A. Fujikawa, K. Sato, T. Kumasaka, M. Yamamoto, K. Ogata
Acta Crystallographica Section D: Biological Crystallography   57 1655-1658   Nov 2001
c-Myb and the C/EBP family are transcriptional regulatory factors that act in concert to regulate the expression of myeloid-specific genes, v-Myb encoded by avian myeloblastosis virus (AMV) is a mutated form of c-Myb that contains point mutations ...
T. H. Tahirov, T. Inoue-Bungo, M. Sasaki, M. Shiina, K. Kimura, K. Sato, T. Kumasaka, M. Yamamoto, N. Kamiya, K. Ogata
Acta Crystallographica Section D: Biological Crystallography   57 850-853   Jul 2001
Three types of protein - DNA complexes, AML1/Runx-1/ CBFα(Runt) - CBFβ - C/EBPβ(bZip) - DNA (CBFα-β-C/EBPβ-DNA), AML1/Runx-1/CBFα(Runt) - C/EBPβ(bZip) - DNA (CBFα-C/EBPβ-DNA) and AML1/Runx-1/CBFα(Runt) - DNA (CBFα-DNA), were crystallized. The crys...
T. H. Tahirov, T. Inoue-Bungo, M. Sasaki, A. Fujikawa, K. Kimura, K. Sato, S. I. Adachi, N. Kamiya, K. Ogata
Acta Crystallographica Section D: Biological Crystallography   57 854-856   Jul 2001
The C-terminal fragment (residues 259-345) of human C/EBPβ, a basic region leucine zipper transcriptional regulatory factor which includes the minimal DNA-binding domain, was crystallized in complex with a 16 bp DNA fragment from the tom-1 promote...
Tahir H. Tahirov, Taiko Inoue-Bungo, Hisayuki Morii, Atsushi Fujikawa, Motoko Sasaki, Kazumi Kimura, Masaaki Shiina, Ko Sato, Takashi Kumasaka, Masaki Yamamoto, Shunsuke Ishii, Kazuhiro Ogata
Cell   104(5) 755-767   Mar 2001
The core binding factor (CBF) heterodimeric transcription factors comprised of AML/CBFA/PEBP2α/Runx and CBFβ/PEBP2β subunits are essential for differentiation of hematopoietic and bone cells, and their mutation is intimately related to the develop...
Motoko Sasaki, Kazuhiro Ogata, Hideki Hatanaka, Yoshifumi Nishimura
Journal of Biochemistry   127(6) 945-953   Jul 2000
The DNA-binding domain of c-Myb consists of three imperfect tandem repeats, R1, R2, and R3. Each repeat contains three helices. The minimal DNA- binding domain is an R2R3 fragment. Here, we have examined the backbone dynamics of R2R3 in its DNA-bo...
Hisayuki Morii, Hatsuho Uedaira, Kazuhiro Ogata, Shunsuke Ishii, Akinori Sarai
Journal of Molecular Biology   292(4) 909-920   Oct 1999
The shape and the energetics of a functional cavity in the R2 subdomain (90-141) of the c-Myb DNA-binding domain were investigated by spectroscopy and thermodynamic analysis. We focused on the valine 103 residue located in front of the cavity. Nin...
Tahir H. Tahirov, Hisayuki Morii, Hatsuho Uedaira, Akinori Sarai, Kazuhiro Ogata
Acta Crystallographica Section D: Biological Crystallography   55 1345-1347   Jul 1999
The R2 subdomain of the mouse c-Myb DNA-binding domain and its V103L mutant have been crystallized by the vapour-diffusion method using highly concentrated sodium citrate at pH 6.8 as a precipitant. Using ammonium sulfate as precipitant in MES buf...
Tahir H. Tahirov, Hideyuki Oki, Tomitake Tsukihara, Kyoko Ogasahara, Katsuhide Yutani, Kazuhiro Ogata, Yukiko Izu, Susumu Tsunasawa, Ikunoshin Kato
Journal of Molecular Biology   284(1) 101-124   Nov 1998
The structure of methionine aminopeptidase from hyperthermophile Pyrococcus furiosus (PfMAP) with an optimal growth temperature of 100°C was determined by the multiple isomorphous replacement method and refined in three different crystal forms, on...
Hatsuho Uedaira, Hisayuki Morii, Kazuhiro Ogata, Shunsuke Ishii, Akinori Sarai
Pure and Applied Chemistry   70 671-676   Mar 1998
The DNA binding domain of c-Myb protein, a regulator of the transcription, consists of three homologous tandem repeats (R1, R2 and R3) with 51-52 amino acid residues. Previously, we found that the thermal transition of the binding domain (R1R2R3) ...
Masayuki Oda, Koji Furukawa, Kazuhiro Ogata, Akinori Sarai, Haruki Nakamura
Journal of Molecular Biology   276(3) 571-590   Feb 1998
The thermodynamics of the c-Myb DNA-binding domain (R2R3) interaction with its target DNA have been analyzed using isothermal titration calorimetry and amino acid mutagenesis. The enthalpy of association between the standard R2R3, the Cys130 mutan...
Masayuki Oda, Koji Furukawa, Kazuhiro Ogata, Akinori Sarai, Shunsuke Ishii, Yoshifumi Nishimura, Haruki Nakamura
Protein Engineering   10 31   Dec 1997
Masayuki Oda, Koji Furukawa, Kazuhiro Ogata, Akinori Sarai, Shunsuke Ishii, Yoshifumi Nishimura, Haruki Nakamura
Protein Engineering   10(12) 1407-1414   Dec 1997
The individual repeats, R2 and R3, of the minimum specific DNA-binding domain (R2R3) of c-Myb have very similar structures, with a helix-turn-helix variation motif, although their sequence identity in the tandem repeats is only 31%. From previous ...

Books etc

 
The c-Myb DNA binding domain: from molecular structure to function ed. by J. Frampton. Myb Transcription Factors: Their Role in Growth, Differentiation and Disease (pp.223-238)
Ogata K, Tahirov TH, Ishii S
2004   

Conference Activities & Talks

 
Molecular behavior of a higher-order complex of multiple transcription factors on enhancer site upon phosphorylation
Ogata K, Shiina M, Kasahara K, Higo J, Hamada K, Nakamura H
6th International Conference on Structural Biology - Structural Biology 2016   22 Aug 2016   
Molecular mechanism for modulation of a multiple transcription factor complex formed on enhancer site up on phosphorylation
Ogata K, Shiina M, Kasahara K, Higo J, Hamada K, Nakamura H
5th International Conference and Exhibition on Metabolomics   18 May 2016   
Structural analyses for the effects of Ets1 phosphorylation on Ets1-containing TF-DNA assemblies
Shiina M, Hamada K, Inoue-Bungo T, Shimamura M, Uchiyama A, Baba S, Sato K, Yamamoto M, Tahirov TH, Ogata K
HUPO 2013(12th Human Proteome Organization Annual World Congress)   Oct 2013   
Crystal structural analysis of drosophila nucleosome assembly protein
Hamada K, Shiina M, Nakashima R, Saito M, Ito T, Ogata K
4th International Symposium on Diffraction Structural Biology   May 2013   
DNA-mediated allosteric regulation in a complex of multiple transcription factors with DNA
Shiina M, Hamada K, Inoue-Bungo T, Shimamura M, Uchiyama A, Baba S, Sato K, Ogata K
4th International Symposium on Diffraction Structural Biology   May 2013   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究)
Project Year: 2005 - 2009    Investigator(s): Kazuhiro OGATA
Multiple transcription factors (TFs) regulate transcription by forming TFs-DNA complexes. A cell signaling causes chemical modification of transcription factors, which modulates transcriptional activities. Besides, effect of chemical modification ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2004 - 2005    Investigator(s): Kazuhiro OAGATA
The goal of this project is to elucidate molecular mechanisms for regulating the enhanceosome formation, particularly, stabilization of transcription factors bound to an enhancer region of a gene.We investigated some complexes containing a transcr...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2002 - 2003    Investigator(s): Kazuhiro OGATA
This research project aimed to elucidate a molecular mechanism for transcriptional regulation by multiple transcriptional regulatory proteins. We focused on some hematopoietic transcriptional regulatory proteins, such as Runxl, CBFβ, c-Myb, C/EBP,...