Fumio Nakamura

Profile Information

Affiliation: Professor and Head of Division, Biochemistry, Tokyo Women's Medical University

Degree: MD PhD

J-GLOBAL ID: 201201043267686895
researchmap Member ID: 7000000566

External link: http://www.twmu.ac.jp/

Research Interests

Research Areas

Research History

Associate Professor, Yokohama City University School of Medicine, Medical Course, Pharmacology and Neurobiology, Medical Studies

Committee Memberships

学術評議員, 日本薬理学会

Papers

100

Monoallelic CRMP1 gene variants cause neurodevelopmental disorder.

Ethiraj Ravindran, Nobuto Arashiki, Lena-Luise Becker, Kohtaro Takizawa, Jonathan Lévy, Thomas Rambaud, Konstantin L Makridis, Yoshio Goshima, Na Li, Maaike Vreeburg …

eLife, 11, Dec 13, 2022
Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis

Yuko Kawamoto, Mikiko Tada, Tetsuya Asano, Haruko Nakamura, Aoi Jitsuki-Takahashi, Hiroko Makihara, Shun Kubota, Shunta Hashiguchi, Misako Kunii, Toshio Ohshima …

Frontiers in Neurology, 13, Sep 27, 2022
The Sympathetic Nervous System Contributes to the Establishment of Pre-Metastatic Pulmonary Microenvironments.

Katsuaki Ieguchi, Masabumi Funakoshi, Taishi Mishima, Kohtaro Takizawa, Tsutomu Omori, Fumio Nakamura, Makoto Watanabe, Mayumi Tsuji, Yuji Kiuchi, Shinichi Kobayashi …

International journal of molecular sciences, 23(18), Sep 13, 2022
Inhibition of Crmp1 phosphorylation at Ser522 ameliorates motor function and neuronal pathology in amyotrophic lateral sclerosis model mice.

Tetsuya Asano, Haruko Nakamura, Yuko Kawamoto, Mikiko Tada, Yayoi Kimura, Hiroshi Takano, Ryoji Yao, Hiroya Saito, Takuya Ikeda, Hiroyasu Komiya …

eNeuro, 9(3), May 6, 2022
Storage-Related Changes in Autologous Whole Blood and Irradiated Allogeneic Red Blood Cells and Their Ex Vivo Effects on Deformability, Indices, and Density of Circulating Erythrocytes in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass

Junko Ichikawa, Ichiro Koshino, Nobuto Arashiki, Fumio Nakamura, Makiko Komori

Journal of Cardiothoracic and Vascular Anesthesia, 36(3) 855-861, Mar, 2022 Peer-reviewed
Right ventricular overloading is attenuated in monocrotaline-induced pulmonary hypertension model rats with a disrupted Gpr143 gene, the gene that encodes the 3,4-l-dihydroxyphenyalanine (l-DOPA) receptor.

Masayuki Nakano, Motokazu Koga, Tatsuo Hashimoto, Natsuki Matsushita, Daiki Masukawa, Yusuke Mizuno, Hiraku Uchimura, Ryo Niikura, Tomoyuki Miyazaki, Fumio Nakamura …

Journal of pharmacological sciences, 148(2) 214-220, Feb, 2022
One-step visualization of natural cell activities in non-labeled living spheroids.

Shotaro Tanaka, Kotaro Takizawa, Fumio Nakamura

Scientific reports, 12(1) 1500-1500, Jan 27, 2022
Construction of the ELISA assay to quantify Semaphorin 3A in the adult brain

Naoya Yamashita, Yui Mizutani, Aoi Jitsuki-Takahashi, Ke-Yi Lin, Fumio Nakamura, Takashi Sakurai, Yoshio Goshima

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95 3-P, 2022
Distribution of mRNA for GPR143, a receptor of 3,4-L-dihydroxyphenylalanine, and of immunoreactivities for nicotinic acetylcholine receptors in the nigrostriatal and mesolimbic regions

Yuka Kasahara, Daiki Masukawa, Yoshie Nakamura, Koshi Murata, Tatsuo Hashimoto, Kohtaro Takizawa, Motokazu Koga, Fumio Nakamura, Yugo Fukazawa, Kengo Funakoshi …

Neuroscience Research, 170 370-375, Sep, 2021
Clinical evidence that a dysregulated master neural network modulator may aid in diagnosing schizophrenia.

Munetaka Nomoto, Glenn T Konopaske, Naoya Yamashita, Reina Aoki, Aoi Jitsuki-Takahashi, Haruko Nakamura, Hiroko Makihara, Mari Saito, Yusuke Saigusa, Fumio Nakamura …

Proceedings of the National Academy of Sciences of the United States of America, 118(31), Aug 3, 2021
Secondary Publication: The Pathophysiology of COVID-19 (Coronavirus Disease 2019) Caused by the Infection of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2)

Ayako Nakamura-Ishizu, Fumio Nakamura

Tokyo Women’s Medical University Journal, 91(1) 11-18, Jul, 2021 Peer-reviewedInvited
Activity-induced secretion of semaphorin 3A mediates learning.

Aoi Jitsuki-Takahashi, Susumu Jitsuki, Naoya Yamashita, Meiko Kawamura, Manabu Abe, Kenji Sakimura, Akane Sano, Fumio Nakamura, Yoshio Goshima, Takuya Takahashi

The European journal of neuroscience, 53(10) 3279-3293, May, 2021
Phosphorylation of Collapsin Response Mediator Protein 1 (CRMP1) at Tyrosine 504 residue regulates Semaphorin 3A‐induced cortical dendritic growth

Takeshi Kawashima, Aoi Jitsuki‐Takahashi, Kohtaro Takizawa, Susumu Jitsuki, Takuya Takahashi, Toshio Ohshima, Yoshio Goshima, Fumio Nakamura

Journal of Neurochemistry, 157 1207-1221, Jan 31, 2021 Peer-reviewedLast authorCorresponding author
Reduction in flippase activity contributes to surface presentation of phosphatidylserine in human senescent erythrocytes.

Momoko Seki, Nobuto Arashiki, Yuichi Takakuwa, Kosaku Nitta, Fumio Nakamura

Journal of cellular and molecular medicine, 24 13991-14000, Oct 26, 2020 Peer-reviewedLast authorCorresponding author
Low Incidence of High-Grade Pancreatic Intraepithelial Neoplasia Lesions in a Crmp4 Gene-Deficient Mouse Model of Pancreatic Cancer.

Keiichi Yazawa, Fumio Nakamura, Daiki Masukawa, Sho Sato, Yukihiko Hiroshima, Yasuhiro Yabushita, Ryutaro Mori, Ryusei Matsuyama, Ikuma Kato, Hideki Taniguchi …

Translational oncology, 13(3) 100746-100746, Feb 24, 2020 Peer-reviewed
Alteration of the protein levels and/or posttranslational modification of CRMP 2 (Collapsin Response Mediator Protein 2) in the peripheral blood samples from young schizophrenia patients

Munetaka Nomoto, Naoya Yamashita, Aoi Jitsuki-Takahashi, Haruko Nakamura, Hiroko Makihara, Fumio Nakamura, Snyder Evan Y, Yoshio Hirayasu, Yoshio Goshima

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 93 2-P, 2020
Collapsin Response Mediator Proteins: Their Biological Functions and Pathophysiology in Neuronal Development and Regeneration.

Fumio Nakamura, Toshio Ohshima, Yoshio Goshima

Frontiers in cellular neuroscience, 14 188-188, 2020 Peer-reviewed
Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease.

Aladeokin AC, Akiyama T, Kimura A, Kimura Y, Takahashi-Jitsuki A, Nakamura H, Makihara H, Masukawa D, Nakabayashi J, Hirano H …

Neurobiology of disease, 132 104603-104603, Dec, 2019 Peer-reviewed
Immunoreactivity of a G protein-coupled l-DOPA receptor GPR143, in Lewy bodies.

Goshima Y, Watanabe S, Seki E, Koga M, Masukawa D, Nakamura F, Komori T, Arai N

Neuroscience research, 148 49-53, Nov, 2019 Peer-reviewed
Changes in Erythrocyte Morphology at Initiation of Cardiopulmonary Bypass Without Blood Transfusion Were Not Associated With Less Deformability During Cardiac Surgery.

Ichikawa J, Koshino I, Arashiki N, Nakamura F, Komori M

Journal of cardiothoracic and vascular anesthesia, 33(11) 2960-2967, Nov, 2019 Peer-reviewed

Misc.

統合失調症患者由来血液検体におけるCRMP2およびそのリン酸化修飾レベルの変化

五嶋良郎, 野本宗孝, 野本宗孝, 山下直也, 山下直也, 實木(高橋)葵, 實木(高橋)葵, 中村治子, 中村治子, 槙原弘子 …

臨床薬理, 50(Supplement), 2019
Collapsin response mediator protein 1 (CRMP1) and CRMP2 mediate Semaphorin3A signaling through distinct pathway in vivo

Hiroko Makihara, Shiori Nakai, Aoi Jitsuki-Takahashi, Haruko Nakamura, Naoya. Yamashita, Hiroshi Kiyonari, Go Shioi, Fumio Nakamura, Fumiaki Tanaka, Yoshio Goshima

JOURNAL OF PHARMACOLOGICAL SCIENCES, 130(3) S155-S155, Mar, 2016
皮膚における神経免疫クロストーク

中村史雄, 五嶋良郎, 相原道子

最新医学, 71(2), 2016 Peer-reviewed
L‐DOPAによって誘発される行動薬理学的変化の解析

上田傑, 増川太輝, 古賀資和, 中村史雄, 五嶋良郎

日本薬理学会関東部会プログラム・要旨集, 132nd 88, 2015
GPR143遺伝子欠損マウスにおけるドパミン受容体作動薬の効果

北村慧, 増川太輝, 古賀資和, 中村史雄, 五嶋良郎

日本薬理学会関東部会プログラム・要旨集, 133rd 44, 2015
DOPA-INDUCED DEPRESSOR AND BRADYCARDIAC RESPONSE IN THE OA1-DEFICIENT MICE

D. Masukawa, F. Nakamura, Y. Goshima

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 115 260-260, Jul, 2014
THE GENE PRODUCT OF OCULAR ALBINISM 1 IS THE G PROTEIN-COUPLED RECEPTOR AND MEDIATES DEPRESSOR AND BRADYCARDIC RESPONSES TO DOPA IN THE NUCLEUS TRACTUS SOLITARII

Y. Goshima, F. Nakamura, D. Masukawa

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 115 280-280, Jul, 2014
Distribution of L-DOPA receptor, ocular albinism 1 (OA-1)-immunoreactivities in central and peripheral tissues

Nobuhiko Fukuda, Saki Naito, Daiki Masukawa, Moemi Kaneda, Fumio Nakamura, Yoshio Goshima

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 208P-208P, 2014
OA1 mediates L-DOPA induced Ca2+response in cultured hippocampal neurons

Fumio Nakamura, Moemi Kaneda, Yoshio Goshima

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 208P-208P, 2014
中枢神経系におけるOA1の分布と機能

増川太輝, 中村史雄, 古賀資和, 五嶋良郎

日本薬理学会関東部会プログラム・要旨集, 131st 46, 2014
中枢神経系におけるL‐DOPA受容体OA1の発現分布

増川太輝, 中村史雄, 古賀資和, 五嶋良郎

日本薬理学会関東部会プログラム・要旨集, 130th 41, 2014
Semaphorin3Aの減少は関節リウマチ患者の滑膜炎、臨床症状に影響を与える

高川修, 熊谷研, 長岡亜紀子, 針金健吾, 草山喜洋, 大歳晃生, 仲拓磨, 長嶋洋治, 中村史雄, 稲葉裕 …

日本関節病学会誌, 32(3) 333-333, Oct, 2013
L-DOPA induces Ca2+ response via L-DOPA receptor candidate, OA1

Moemi Kaneda, Fumio Nakamura, Hidenori Muraoka, Yoshio Goshima

JOURNAL OF PHARMACOLOGICAL SCIENCES, 121 134P-134P, 2013
Immunohistochemical examination of OA1, a receptor candidate for L-3,4-dihydroxyphenylalanine, in the CNS

Marina Kamiya, Naoya Yamashita, Yukio Sasaki, Fumio Nakamura, Yoshio Goshima

JOURNAL OF PHARMACOLOGICAL SCIENCES, 118 134P-134P, 2012
The interaction of CRMP1 and the actin binding domain of Filamin-A mediates Sema3A signaling

Fumio Nakamura, Tomonobu Hida, Yoshio Goshima

JOURNAL OF PHARMACOLOGICAL SCIENCES, 118 182P-182P, 2012
Ocular albinism-1 (OA-1) is a G-protein coupled receptor that mediates L-DOPA-induced depressor and bradycardic responses in rat nucleus tractus solitarii

Yoshio Goshima, Fumio Nakamura, Yukihiko Hiroshima, Hirosi Miyamoto, Naoya Yamashita, Itaru Endou

JOURNAL OF PHARMACOLOGICAL SCIENCES, 118 63P-63P, 2012
内在性Nogo66受容体アンタゴニストLOTUSの機能ドメイン検索(Functional domain of LOTUS serving as endogenous Nogo66 receptor antagonist)

栗原裕司, 池谷真澄, 伊藤拓夢, 西山邦幸, 榊原裕介, 中村史雄, 水木信久, 五嶋良郎, 竹居光太郎

神経化学, 50(2-3) 170-170, Sep, 2011
Identification of a functional domain in endogenous Nogo66 receptor antagonist LOTUS

Yuji Kurihara, Masumi Iketani, Hiromu Itoh, Kuniyuki Nishiyama, Fumio Nakamura, Nobuhisa Mizuki, Yoshio Goshima, Kohtaro Takei

NEUROSCIENCE RESEARCH, 71 E337-E337, 2011
Promotion of neurite outgrowth by an endogenous Nogo66 receptor antagonist LOTUS

Hiromu Ito, Yuji Kurihara, Masumi Iketani, Kuniyuki Nishiyama, Fumio Nakamura, Yoshio Goshima, Kohtaro Takei

NEUROSCIENCE RESEARCH, 71 E131-E132, 2011
Semaphorin3A facilitates the axonal transport of PlexinA4 through interaction of PlexinA4 with TrkA

Masayuki Yamane, Naoya Yamashita, Yukio Sasaki, Fumio Nakamura, Yoshio Goshima

NEUROSCIENCE RESEARCH, 71 E119-E119, 2011

Presentations

PTPdelta mediates Semaphorin-3A-induced dendritic growth of cortical pyramidal neurons

NAKAMURA Fumio

Workshop on Frontiers in Phosphatase Research and Drug Discovery, Oct 23, 2018
CRMP1 phosphorylation at Tyr504 participates in Sema3A-signaling

Kawashima T, Goshima Y, Nakamura F

Cold Spring Harbor Lab, Molecular Mechanism of Neuronal connectivity, Sep 25, 2018
Protein tyrosine phosphatase delta mediates Sema3A-induced cortical basal dendritic formation

Nakamura F, Goshima Y, Strittmatter SM

Cold Spring Harbor Lab, Axon guidance meeting, Sep 20, 2016
Sema3A(-/-) マウスにおける海馬 CA1 錐体細胞の形態学的解析

日本神経科学大会, 2008
Morphological analysis of hippocampal CA1 pyramidal neurons in sema3A(-/-) mice

Japan Neuroscience Society, 2008
ＰＴＰδ変異マウスにおける嗅内野海馬投射の検討

第３０回日本神経科学大会, 2007

Professional Memberships

Research Projects

An identification of the signaling pathway involving in Sema3A-induced breakdown of the asymmetric distribution in the developing neuron's membrane

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2026
赤血球のセマフォリン7Aを標的とした耐性のない抗マラリア治療法を探る

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

越野一朗, 中村史雄
マスト細胞分泌顆粒プロテオミクスを活用したアレルギー治療標的候補遺伝子の探索

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

田中正太郎, 武山廉, 中村史雄
Sema3A-PTPdelta signaling regulates cortical dendritic growth

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Nakamura Fumio, Jitsuki Aoi, Shishikura Maria, Kawashima Takeshi, Okada Takako, Goshima Yoshio
Functional analysis of DOPAergic transmission in cardiovascular system

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

GOSHIMA Yoshio, FUKAZAWA Yugo, ICHINOSE Hiroshi
Interaction of CRMP1 and Filamin-A regulates F-actin-cytoskeleton.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

NAKAMURA Fumio, ARITA Kyohei, YAMASHITA Naoya, HASHIMOTO Hiroshi
Functional of GPR143, a novel G protein-coupled receptor for L-DOPA

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

GOSHIMA Yoshio, NAKAMURA Fumio, OIKAWA Masato, SUZUKI Tsutomu, OKABE Takayoshi, FUKUNISHI Yoshifumi
Aberrant epidermal expression of semaphorin 3A in pruritic skin diseases and development of new therapeutic drugs for pruritus

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

AIHARA Michiko, GOSHIMA Yoshio, NAGASHIMA Yoji, IKEZAWA Zenro, NAKAMURA Humio
Exploring Optical Navigation of Neurite Outgrowth

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2010 - 2011

NAKAMURA Fumio, ISEKI Mineo
The role of CRMP family proteins in the establishment of neural tissue architectures

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2005 - 2009

GOSHIMA Yoshio, OOSHIMA Toshio
Biological analysis of a novel axon guidance molecule, LOTUS/cep68

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2006 - 2008
Functional analysis of novel G-coupled receptor candidate for L-DOPA and structural determination of its ligands

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2004 - 2005

GOSHIMA Yoshio, YAGAMI Tatsuro, NAKAMURA Fumio, KAJIWARA Yasuhiro, KAMIYA Yoshitaka
The role of protein tyrosine phosphatase δ in axon guidance

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2004

NAKAMURA Fumio
Isolation and characterization of a receptor candidate for L-DOPA in C.elegans

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2002 - 2003

GOSHIMA Yoshio, KATURA Isao, OGURA Ken-ichi, NAKAMURA Fumio
The relation between LAR class protein tyrosine phosphates and Semaphorin-Plexin signaling

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2001 - 2002

NAKAMURA Fumio, OGURA Ken-ichi, SASAKI Yukio
軸索伸長抑制因子Nogoの受容体同定とセマフォリンの細胞内情報伝達系の解明

科学研究費助成事業, 特定領域研究(C), 日本学術振興会, 2000 - 2000

中村史雄, 佐々木幸生

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