MISC

2015年3月

IRE-1/XBP-1 pathway of the unfolded protein response is required for properly localizing neuronal UNC-6/Netrin for axon guidance in C. elegans

GENES TO CELLS
  • Taro Asakura
  • ,
  • Ken-ichi Ogura
  • ,
  • Yoshio Goshima

20
3
開始ページ
153
終了ページ
159
記述言語
英語
掲載種別
DOI
10.1111/gtc.12206
出版者・発行元
WILEY-BLACKWELL

During developing nervous system, neurons project axons to their targets precisely. In this process, axon guidance molecules provide positional information to the axons. Therefore, the spatially and temporally controlled localization of the axon guidance molecules is required for the proper structure formation of the complex nervous system. In C.elegans, UNC-6/Netrin is a secreted protein that elicits both attractive and repulsive response in axon guidance. UNC-6/Netrin secreted from ventral cells may establish a concentration gradient from the ventral to the dorsal side of the animal, thus providing dorso-ventral positional information. However, the mechanisms specifying positional information of UNC-6/Netrin are largely unknown. Here, we show that the ire-1/xbp-1 pathway of the unfolded protein response (UPR) is required for axonal distribution of UNC-6/Netrin in the ventral neurons. In addition, the ire-1/xbp-1 pathway is also required for dorso-ventral axon guidance mediated by UNC-6/Netrin. Our results suggest that the ire-1/xbp-1 pathway of the UPR is crucial for establishing positional information of UNC-6/Netrin. We propose that the proper secretion of UNC-6/Netrin from the ventral neurons requires the activity of IRE-1.

リンク情報
DOI
https://doi.org/10.1111/gtc.12206
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25469499
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000350505100001&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84923765449&origin=inward
ID情報
  • DOI : 10.1111/gtc.12206
  • ISSN : 1356-9597
  • eISSN : 1365-2443
  • PubMed ID : 25469499
  • SCOPUS ID : 84923765449
  • Web of Science ID : WOS:000350505100001

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