2011年11月
A Seven-Transmembrane Receptor That Mediates Avoidance Response to Dihydrocaffeic Acid, a Water-Soluble Repellent in Caenorhabditis elegans
JOURNAL OF NEUROSCIENCE
- 巻
- 31
- 号
- 46
- 開始ページ
- 16603
- 終了ページ
- 16610
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1523/JNEUROSCI.4018-11.2011
- 出版者・発行元
- SOC NEUROSCIENCE
The ability to detect harmful chemicals rapidly is essential for the survival of all animals. In Caenorhabditis elegans (C. elegans), repellents trigger an avoidance response, causing animals to move away from repellents. Dihydrocaffeic acid (DHCA) is a water-soluble repellent and nonflavonoid catecholic compound that can be found in plant products. Using a Xenopus laevis (X. laevis) oocyte expression system, we identified a candidate dihydrocaffeic acid receptor (DCAR), DCAR-1. DCAR-1 is a novel seven-transmembrane protein that is expressed in the ASH avoidance sensory neurons of C. elegans. dcar-1 mutant animals are defective in avoidance response to DHCA, and cell-specific expression of dcar-1 in the ASH neurons of dcar-1 mutant animals rescued the defect in avoidance response to DHCA. Our findings identify DCAR-1 as the first seven-transmembrane receptor required for avoidance of a water-soluble repellent, DHCA, in C. elegans.
- リンク情報
-
- DOI
- https://doi.org/10.1523/JNEUROSCI.4018-11.2011
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/22090488
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000297215200014&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=81255211975&origin=inward
- ID情報
-
- DOI : 10.1523/JNEUROSCI.4018-11.2011
- ISSN : 0270-6474
- PubMed ID : 22090488
- SCOPUS ID : 81255211975
- Web of Science ID : WOS:000297215200014