MISC

2011年1月

Mutation in a mitochondrial ribosomal protein causes increased sensitivity to oxygen with decreased longevity in the nematode Caenorhabditis elegans

GENES TO CELLS
  • Michihiko Fujii
  • ,
  • Kazuki Shikatani
  • ,
  • Ken-Ichi Ogura
  • ,
  • Yoshio Goshima
  • ,
  • Dai Ayusawa

16
1
開始ページ
69
終了ページ
79
記述言語
英語
掲載種別
DOI
10.1111/j.1365-2443.2010.01469.x
出版者・発行元
WILEY-BLACKWELL

Oxygen is essential for animals, but high concentrations of oxygen are toxic to them probably because of an increase in reactive oxygen species (ROS). Many genes are involved in the reactions from which ROS are generated, but not much attention has been focused on them. To identify these genes, we screened for mutants with an altered sensitivity to oxidative stress in the nematode Caenorhabditis elegans and isolated a mutant, oxy-5(qa5002). oxy-5 showed an increased sensitivity to oxygen and decreased longevity. The decreased life span in oxy-5 was probably due to increased oxidative stress because it was recovered to a normal level when oxy-5 was cultured under hypoxic conditions. Our genetic analysis has revealed that the responsible gene for oxy-5 encodes a protein similar to mitochondrial ribosomal protein S36. The OXY-5 protein was highly expressed in the neurons, pharynx, and intestine, and expression of oxy-5 from the pan-neuronal H20 promoter efficiently suppressed the increased sensitivity to oxygen in oxy-5. These findings suggested that oxy-5 played an important role in the regulation of the sensitivity to oxygen in neuronal cells in C. elegans.

リンク情報
DOI
https://doi.org/10.1111/j.1365-2443.2010.01469.x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/21156009
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000285762500007&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78650644717&origin=inward
ID情報
  • DOI : 10.1111/j.1365-2443.2010.01469.x
  • ISSN : 1356-9597
  • PubMed ID : 21156009
  • SCOPUS ID : 78650644717
  • Web of Science ID : WOS:000285762500007

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