論文

査読有り
2016年11月

Impact of Helicobacter pylori Immunoglobulin G Levels and Atrophic Gastritis Status on Risk of Metabolic Syndrome

PLOS ONE
  • Atsushi Takeoka
  • ,
  • Jun Tayama
  • ,
  • Hironori Yamasaki
  • ,
  • Masakazu Kobayashi
  • ,
  • Sayaka Ogawa
  • ,
  • Tatsuo Saigo
  • ,
  • Masaki Hayashida
  • ,
  • Susumu Shirabe

11
11
開始ページ
e0166588
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.016658
出版者・発行元
PUBLIC LIBRARY SCIENCE

Background
Helicobacter pylori (HP) infection is implicated in gastric and extra-gastric diseases. While gastritis-related chronic inflammation represents a known trigger of metabolic disturbances, whether metabolic syndrome (MetS) is affected by gastritis status remains unclear. We aimed to clarify the effect of HP-related gastritis on the risk of MetS.
Materials and Methods
We retrospectively enrolled patients undergoing screening for MetS between 2014 and 2015. Investigations included HP-specific immunoglobulin G (IgG) antibody assays to detect HP infection, and serum pepsinogen assays to evaluate atrophic gastritis status. The risk of MetS was evaluated via multiple logistic regression analyses with two covariates: serum HP infection status (IgG levels) and atrophic gastritis status (two criteria were applied; pepsinogen I/II ratio < 3 or both pepsinogen I levels <= 70 mu g/L and pepsinogen I/II ratio < 3).
Results
Of 1,044 participants, 247 (23.7%) were HP seropositive, and 62 (6.0%) had MetS. HP seronegative and seropositive patients had similar risks of MetS. On the other hand, AG (defined in terms of serum PG I/II < 3) was significant risk of MetS (OR of 2.52 [95% CI 1.05-7.52]). After stratification according to HP IgG concentration, patients with low HP infection status had the lowest MetS risk (defined as an odds ratio [OR] adjusted for age, sex, smoking, drinking and physical activity status). Taking this result as a reference, patients with negative, moderate, and high HP infection status had ORs (with 95% confidence intervals [CI]) of 2.15 (1.06-4.16), 3.69 (1.12-16.7), and 4.05 (1.05-26.8).
Conclusions
HP-associated gastritis represents a risk factor for MetS. Research should determine why low and not negative HP infection status is associated with the lowest MetS risk.

リンク情報
DOI
https://doi.org/10.1371/journal.pone.016658
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27851820
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000387909300072&DestApp=WOS_CPL
ID情報
  • DOI : 10.1371/journal.pone.016658
  • ISSN : 1932-6203
  • PubMed ID : 27851820
  • Web of Science ID : WOS:000387909300072

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