YOKOYAMA Utako

J-GLOBAL         Last updated: Sep 11, 2019 at 09:53
 
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Name
YOKOYAMA Utako
Affiliation
Tokyo Medical University
Section
Department of Physiology
Job title
Professor
Degree
Medical doctor(Tokyo Women's Medical University)
Research funding number
70404994

Research Interests

 
 

Research Areas

 
 

Academic & Professional Experience

 
 
   
 
Associate Professor, Yokohama City University School of Medicine Medical Course Graduate School of Medicine Degree Program
 

Education

 
 
 - 
1994
Faculty of Medicine, Okayama University
 

Awards & Honors

 
Apr 2014
血管の分化発達の病態生理の解明とその分子標的治療の確立, JPS Scientific Research Award, Japan Pediatric Society
 
Apr 2011
動脈管閉鎖の分子機序の解明, The 23th Yokohama City University Medical Association Award, Yokohama City University Medical Association
 
Jul 2009
Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A., The 5th HIROSI KURIYAMA AWARD, The Japan Society of Smooth Muscle Research
 
Mar 2009
The Cyclic AMP Effector Epac Integrates Pro- and Anti-Fibrotic Signals, 2nd Woman Researcher's Award, The Japanese Circulation Society
 
Jun 2008
Young Investigator's Award
 
Apr 2007
Postdoctoral fellow Travel Award, American Society for Biochemistry and Melecular Biology
 
Mar 2007
UC San Diego Cardiovascular Scholarship Award, University of California, San Diego
 
Apr 2006
Prostaglandin Promotes Hyaluronic Acid-Induced Neointimal Formation in Ductus Arteriosus, 1st Pediatric Cardiology Award, The Japanese Circulation Society
 
Mar 2007
Vascular Injury-induced Upregulation of Epac1 Counteracts PKA, Promoting Smooth Muscle Cell Migration and Neointimal Thickening, 24th Young Investigator's Award, The Japanese Circulation Society
 

Published Papers

 
The usefulness of exchanged protein directly activated by cAMP (Epac)1-inhibiting therapy for prevention of atrial and ventricular arrhythmias in mice
Prajapati R, Fujita T, Suita K, Nakamura T, Cai W, Hidaka Y, Umemura M, Yokoyama U, Knollmann B, Okumura S, Ishikawa Y.
Circulation journal      2019   [Refereed]
Yokoyama U, Arakawa N, Ishiwata R, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Matsumoto M, Koizumi N, Taguri M, Hirano H, Yoshimura K, Ogino H, Masuda M, Ishikawa Y
American journal of physiology. Heart and circulatory physiology   315(4) H1012-H1018   Jul 2018   [Refereed]
Mamun A, Yokoyama U, Saito J, Ito S, Hiromi T, Umemura M, Fujita T, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Masuda M, Ishikawa Y
Physiological reports   6(18) e13878   Sep 2018   [Refereed]
Umemura M, Islam MR, Fukumura H, Sato I, Kawabata Y, Matsuo K, Nakakaji R, Nagasako A, Ohtake M, Fujita T, Yokoyama U, Nakayama T, Eguchi H, Ishikawa Y
Cancer science      Oct 2018   [Refereed]
Fujita T, Umemura M, Yokoyama U, Okumura S, Ishikawa Y
Cellular and molecular life sciences : CMLS   74(4) 1-16   Aug 2016   [Refereed]

Misc

 
Fibulin-1の動脈管内膜肥厚形成における役割
中川路 太一, 横山 詩子, 伊藤 智子, 石川 義弘
日本病態生理学会雑誌   27(2) 40-40   Jul 2018
横山詩子, 伊藤智子, 石川義弘
日本結合組織学会学術大会抄録集   50th 95   Jun 2018
胎盤由来プロスタグランディンEはFibulin-1を介した動脈管リモデリングを促進する
横山 詩子, 伊藤 智子, 石川 義弘
日本結合組織学会学術大会プログラム・抄録集   50回 95-95   Jun 2018
肺血管の発達と密接な関連を有する動脈管の発達
横山 詩子
日本小児肺循環研究会プログラム・抄録集   24回 36-36   Feb 2018
横山詩子
日本小児肺循環研究会プログラム・抄録集   24th 36   2018

Conference Activities & Talks

 
How ”Human arterial graft” should be fabricated?
YOKOYAMA Utako
CBS 2018- IEEE International Conference on Cyborg and Bionic Systems   27 Oct 2018   
Uncovering new GPCR signaling pathways in Prostaglandin E2-mediated vascular remodeling and inflammation
YOKOYAMA Utako
The 9th Federation of the Asian and Oceanian Physiological Societies Congress   30 Mar 2018   
Cardiac-Specific Overexpression of Caveolin-3 Induces Endogenous Cardiac Protection.
2007   
Blockade of T-type Calcium Channels Attenuates Smooth Muscle Cell Migration, Neointimal Formation, and Oxygen-induced Vascular Contraction in Rat Ductus Arteriosus.
2007   
cAMP-dependent Intimal Cushion Formation of the Rat Ductus Arteriosus: The Role of Epac.
2007   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
Project Year: 2012 - 2013    Investigator(s): Utako YOKOYAMA
Elastic fiber formation is disrupted with age and by health conditions including aneurysms and atherosclerosis. Despite considerable progress in the understanding of elastogenesis using the planar culture system and genetically modified animals, i...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2011 - 2013    Investigator(s): Susumu MINAMISAWA
The ductus arteriosus (DA) is an essential fetal artery that closes immediately after birth. However, the molecular mechanisms remain unknown, especially its vascular remodeling. We found that 1) prostaglandin E2 (PGE2) -EP4 signaling decreased el...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2010 - 2012    Investigator(s): Rika AOKI
We assessed the hypothesis that serum hypoosmolality promoted closure of the ductus arteriosus (DA). We showed both from human clinical observations and rat experiments that serum hypoosmolality augmented DA closure. The results suggest the import...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2010 - 2012    Investigator(s): Shinichi SUZUKI
Aortic aneurysm is a common but life-threatening disease among the elderly, for which no effective medical therapy is currently available. Activation of prostaglandin E2 (PGE2) is known to increase the expression of matrix metalloproteinase (MMP) ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2009 - 2011    Investigator(s): Utako YOKOYAMA
Activation of the renin-angiotensin-aldosterone system results in vasoconstriction, cardiac hypertrophy and fibrosis. Established arterial stiffness and cardiac dysfunction are key factors contributing to chronic heart failure. Regulation of intra...