論文

査読有り
2015年12月

In Silico Estimation of Skin Concentration Following the Dermal Exposure to Chemicals

PHARMACEUTICAL RESEARCH
  • Tomomi Hatanaka
  • ,
  • Shun Yoshida
  • ,
  • Wesam R. Kadhum
  • ,
  • Hiroaki Todo
  • ,
  • Kenji Sugibayashi

32
12
開始ページ
3965
終了ページ
3974
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s11095-015-1756-5
出版者・発行元
SPRINGER/PLENUM PUBLISHERS

To develop an in silico method based on Fick's law of diffusion to estimate the skin concentration following dermal exposure to chemicals with a wide range of lipophilicity.
Permeation experiments of various chemicals were performed through rat and porcine skin. Permeation parameters, namely, permeability coefficient and partition coefficient, were obtained by the fitting of data to two-layered and one-layered diffusion models for whole and stripped skin. The mean skin concentration of chemicals during steady-state permeation was calculated using the permeation parameters and compared with the observed values.
All permeation profiles could be described by the diffusion models. The estimated skin concentrations of chemicals using permeation parameters were close to the observed levels and most data fell within the 95% confidence interval for complete prediction. The permeability coefficient and partition coefficient for stripped skin were almost constant, being independent of the permeant's lipophilicity.
Skin concentration following dermal exposure to various chemicals can be accurately estimated based on Fick's law of diffusion. This method should become a useful tool to assess the efficacy of topically applied drugs and cosmetic ingredients, as well as the risk of chemicals likely to cause skin disorders and diseases.

Web of Science ® 被引用回数 : 12

リンク情報
DOI
https://doi.org/10.1007/s11095-015-1756-5
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26195007
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000363955900015&DestApp=WOS_CPL

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