MISC

2013年

Elevated microsatellite alterations at selected tetra-nucleotide (EMAST) in non-small cell lung cancers-a potential determinant of susceptibility to multiple malignancies

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
  • Hiromasa Arai
  • ,
  • Koji Okudela
  • ,
  • Hisashi Oshiro
  • ,
  • Noriko Komitsu
  • ,
  • Hideaki Mitsui
  • ,
  • Teppei Nishii
  • ,
  • Masahiro Tsuboi
  • ,
  • Akinori Nozawa
  • ,
  • Yasuharu Noishiki
  • ,
  • Kenichi Ohashi
  • ,
  • Kenji Inui
  • ,
  • Munetaka Masuda

6
3
開始ページ
395
終了ページ
410
記述言語
英語
掲載種別
出版者・発行元
E-CENTURY PUBLISHING CORP

The present study evaluated the potential clinicopathologic significance of elevated microsatellite alteration at selected tetra-nucleotide (EMAST) in non-small cell lung cancer (NSCLC). Sixty-five NSCLCs (19 squamous cell carcinomas, 39 adenocarcinomas, one adenosquamous cell carcinoma, and 6 large cell carcinomas) were examined for EMAST in the ten selected tetra-nucleotide markers. Traditional microsatellite instability (MSI) in the five mono-or di-nucleotide markers of the Bethesda panel was also examined, and compared with EMAST. The incidence of EMAST was higher than that of traditional MSI, as 64.6% (42/65) and 12.3% (8/65) tumors respectively exhibited EMAST and traditional MSI in at least one marker. EMAST and traditional MSI appear to occur independently, as no significant association in their incidence was found (Fisher's exact test, P = 0.146). Subjects who exhibited EMAST in two or more markers had a significantly higher incidence of history of other malignant neoplasms (42.9% [9/21]), compared to those with less than two markers (16.3% [7/43] (Chi-square test, P = 0.021)). Taken together, impairment of molecular machinery for maintaining stable replication of the tetra-nucleotide-repeating regions, which would differ from machinery for mono-or di-nucleotide-repeating regions, may elevate susceptibility to NSCLCs and certain neoplastic diseases. Elucidation of the potential molecular mechanism of EMAST is expected to lead to a discovery of a novel genetic background determining susceptibility to NSCLC and other multiple neoplasms. This is the first report describing a clinicopathologic significance of EMAST in NSCLC.

Web of Science ® 被引用回数 : 10

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23412080
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000327433600007&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84881535953&origin=inward

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