Nobuto Kakuda

Profile Information

Affiliation: Faculty of Life and Medical Sciences, Doshisha University

Degree: Master of Engineering(Tokyo Institute of Technology)

J-GLOBAL ID: 201201078583617046
researchmap Member ID: 7000002611

Research Interests

Research Areas

Life sciences / Neuropathology /

Research History

Apr, 2015 - Present

Faculty of Life and Medical Sciences Department of Medical Life Systems, Doshisha University
Sep, 2013 - Mar, 2015

Postdoctral fellow, KU Leuven
Apr, 2011 - Aug, 2013

Researcher, Doshisha University Organization for Research Initiatives and Development
Apr, 2005 - Mar, 2011

株式会社免疫生物研究所

Education

Papers

Switched Aβ43 generation in familial Alzheimer’s disease with presenilin 1 mutation

Nobuto Kakuda, Mako Takami, Masayasu Okochi, Kensaku Kasuga, Yasuo Ihara, Takeshi Ikeuchi

Translational Psychiatry, 11(1) 558-558, Dec, 2021 Peer-reviewedLead authorCorresponding author
Quantitative fractionation of tissue microtubules with distinct biochemical properties reflecting their stability and lability.

Ayaka Hagita, Satoko Wada-Kakuda, Mika Nobuhara, Nobuto Kakuda, Tomohiro Miyasaka

Biochemical and biophysical research communications, 560 186-191, May 13, 2021 Peer-reviewed
A potential defense mechanism against amyloid deposition in cerebellum.

Alam Shahnur, Masaki Nakano, Seiko Ishihara, Nobuto Kakuda, Tomohiro Miyasaka, Hina Uchiyama, Yuuna Shirai, Mohammad Moniruzzaman, Takashi Saito, Takaomi C Saido, Masaki Nishimura, Satoru Funamoto

Biochemical and biophysical research communications, 535 25-32, Jan 8, 2021 Peer-reviewed
γ-Secretase Activity Is Associated with Braak Senile Plaque Stages.

Nobuto Kakuda, Haruyasu Yamaguchi, Kohei Akazawa, Saori Hata, Toshiharu Suzuki, Hiroyuki Hatsuta, Shigeo Murayama, Satoru Funamoto, Yasuo Ihara

The American journal of pathology, 190(6) 1323-1331, Jun, 2020 Peer-reviewedLead authorCorresponding author
Visualization of Amyloid beta Deposits in Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Ikegawa M, Nirasawa T, Kakuda N, Miyasaka T, Kuzuhara Y, Murayama S, Ihara Y

Sep, 2018 Peer-reviewed
Distinct deposition of amyloid-beta species in brains with Alzheimer's disease pathology visualized with MALDI imaging mass spectrometry

Nobuto Kakuda, Tomohiro Miyasaka, Noriyuki Iwasaki, Takashi Nirasawa, Satoko Wada-Kakuda, Junko Takahashi-Fujigasaki, Shigeo Murayama, Yasuo Ihara, Masaya Ikegawa

ACTA NEUROPATHOLOGICA COMMUNICATIONS, 5(1) 73, Oct, 2017 Peer-reviewedLead author
Chronological Profiling of Plasma Native Peptides after Hepatectomy in Pigs: Toward the Discovery of Human Biomarkers for Liver Regeneration

Kohta Iguchi, Etsuro Hatano, Takashi Nirasawa, Noriyuki Iwasaki, Motohiko Sato, Gen Yamamoto, Kenya Yamanaka, Tatsuya Okamoto, Yosuke Kasai, Naohiko Nakamura, Hiroaki Fuji, Tomohito Sakai, Nobuto Kakuda, Satoru Seto, Kojiro Taura, Kei Tashiro, Shinji Uemoto, Masaya Ikegawam

PLOS ONE, 12(1) e0167647, Jan, 2017 Peer-reviewed
Raft-nonassociated γ-secretase活性による脳内Aβ蓄積

角田伸人, 山口晴保, 赤澤宏平, 初田裕幸, 村山繁雄, 舟本聡, 井原康夫

Dementia Japan, 29(3) 422-422, Sep, 2015
Suspected limited efficacy of γ-secretase modulators

Nobuto Kakuda, Kohei Akazawa, Hiroyuki Hatsuta, Shigeo Murayama, Yasuo Ihara

Neurobiology of Aging, 34(4) 1101-1104, Apr, 2013 Peer-reviewedLead author
Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase

Satoru Funamoto, Toru Sasaki, Seiko Ishihara, Mika Nobuhara, Masaki Nakano, Miho Watanabe-Takahashi, Takashi Saito, Nobuto Kakuda, Tomohiro Miyasaka, Kiyotaka Nishikawa, Takaomi C. Saido, Yasuo Ihara

Nature Communications, 4 2529, 2013 Peer-reviewed
Altered ?-secretase activity in mild cognitive impairment and Alzheimer's disease

Nobuto Kakuda, Mikio Shoji, Hiroyuki Arai, Katsutoshi Furukawa, Takeshi Ikeuchi, Kohei Akazawa, Mako Takami, Hiroyuki Hatsuta, Shigeo Murayama, Yasuhiro Hashimoto, Masakazu Miyajima, Hajime Arai, Yu Nagashima, Haruyasu Yamaguchi, Ryozo Kuwano, Kazuhiro Nagaike, Yasuo Ihara

EMBO MOLECULAR MEDICINE, 4(4) 344-352, Apr, 2012 Peer-reviewedLead author
Tannic Acid Is a Natural beta-Secretase Inhibitor That Prevents Cognitive Impairment and Mitigates Alzheimer-like Pathology in Transgenic Mice

Takashi Mori, Kavon Rezai-Zadeh, Naoki Koyama, Gary W. Arendash, Haruyasu Yamaguchi, Nobuto Kakuda, Yuko Horikoshi-Sakuraba, Jun Tan, Terrence Town

JOURNAL OF BIOLOGICAL CHEMISTRY, 287(9) 6912-6927, Feb, 2012 Peer-reviewed
[Amyloid beta protein of CSF].

Kakuda N, Ihara Y

Nihon rinsho. Japanese journal of clinical medicine, 69 Suppl 8 542-545, Oct, 2011 Peer-reviewed
Tannic acid(植物由来ポリフェノール)の脳アミロイド症抑制効果

森隆, 小山直基, 角田伸人, 山口晴保

Dementia Japan, 24(3) 395-395, Sep, 2010
Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by beta-secretase

N Kakuda, S Funamoto, S Yagishita, M Takami, S Osawa, N Dohmae, Y Ihara

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(21) 14776-14786, May, 2006 Peer-reviewedLead author
Transcriptional analysis of the ostA/imp gene involved in organic solvent sensitivity in Escherichia coli

Ohtsu, I, N Kakuda, N Tsukagoshi, N Dokyu, H Takagi, M Wachi, R Aono

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 68(2) 458-461, Feb, 2004 Peer-reviewed
Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein

T Sato, N Dohmae, Y Qi, N Kakuda, H Misonoum, R Mitsumori, H Maruyama, EH Koo, C Haass, K Takio, M Morishima-Kawashima, S Ishiura, Y Ihara

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(27) 24294-24301, Jul, 2003 Peer-reviewed
n-hexane sensitivity of Escherichia coli due to low expression of imp/ostA encoding an 87 kDa minor protein associated with the outer membrane

S Abe, T Okutsu, H Nakajima, N Kakuda, W Ohtsu, R Aono

MICROBIOLOGY-SGM, 149(Pt 5) 1265-1273, May, 2003 Peer-reviewed

Misc.

DIUTHAMEを用いたアルツハイマー病(AD)脳の迅速MALDI質量分析イメージング(Rapid MALDI mass spectrometry imaging for Alzheimer's disease(AD) brain using DIUTHAME)

外山友美子, 武笠結天, 新谷祈, 徳平壮一郎, 大村孝幸, 小谷政弘, 田代晃, 角田伸人, 韮澤崇, 村山繁雄, 内藤康秀, 池川雅哉

JSBMS Letters, 45(Suppl.) 66-66, Aug, 2020
Visualization of mouse brain proteome for the study of lithium neuropharmacology with MALDI-Imaging Mass Spectroscopy

安井悠生, 亀山大樹, 山本康太, 韮澤崇, 梶田遼, 角田伸人, 平田岳史, 池川雅哉

JSBMS Letters, 45(Supplement), 2020
Molecular dissection of renal amyloidosis with MALDI Imaging Mass Spectrometry and shotgun proteomics on paraffin embedded biopsy tissue section

武笠結天, 梶田遼, 韮澤崇, VAN HUYEN Jean-paul Duong, RABANT Marion, BRUNEVAL Patrick, 植田初江, 内木宏延, 角田伸人, 池川雅哉

JSBMS Letters, 45(Supplement), 2020
in depth Proteomics of Hair Follicles of whiskers from W mutant mice

小杉茉由佳, 木下和生, 韮澤崇, 梶田遼, 角田伸人, 池川雅哉

JSBMS Letters, 45(Supplement), 2020
イメージング質量分析法とショットガンプロテオーム解析を用いた脳病理解析

外山友美子, 朴洪宣, 梶田遼, 角田伸人, 宮坂知宏, 韮澤崇, 村山繁雄, 貫名信行, 井原康夫, 池川雅哉

Dementia Japan, 34(4), 2020
In vivoにおけるタウのリン酸化と微小管結合能への影響

萩田彩香, 角田聡子, 延原美香, 角田伸人, 宮坂知宏

Dementia Japan, 34(4), 2020
腎アミロイドーシスのホルマリン固定試料を対象としたイメージング質量分析法と液体クロマトグラフィータンデム型質量分析法を統合したプロテオミクス・ワークフローの確立

武笠結天, 葛原由貴, 寺田恵, 韮澤崇, RABANT Marion, DUONG VAN, HUYEN Jean‐Paul, BRUNEVAL Patrick, 植田初江, 角田伸人, 池川雅哉

JSBMS Letters, 44(3) 51-51, Nov 25, 2019
イメージング質量分析法を用いた拡張型心筋症ハムスターモデルのin depth組織プロテオーム解析

新谷祈, 辻崇, 石田瑞希, 韮澤崇, 角田伸人, 植田初江, 升本英利, 湊谷謙司, 池川雅哉

JSBMS Letters, 44(3) 50‐51-51, Nov 25, 2019
イメージング質量分析法を用いた薬理量リチウム(Li)の脳内分布の解析

安井悠生, 山本康太, 亀山大樹, 角田伸人, 平田岳史, 池川雅哉

JSBMS Letters, 44(Supplement) 132-132, Aug 25, 2019
MALDIイメージング質量分析法とショットガンプロテオミクス法を用いたパラフィン包埋腎生検組織の高深度プロテオーム解析

武笠結天, 梶田遼, 韮澤崇, RABANT Marion, DUONG VAN, HUYEN Jean‐Paul, BRUNEVAL Patrick, 植田初江, 角田伸人, 池川雅哉

JSBMS Letters, 44(Supplement) 125-125, Aug 25, 2019
全身イメージング質量分析法を用いたマウス母乳成分の消化・吸収・代謝プロセスの可視化

小関将人, 辻雄大, 山本卓志, 山口真一, 藤分秀司, 中邨智之, 角田伸人, 谷史人, 池川雅哉

JSBMS Letters, 44(Supplement) 130-130, Aug 25, 2019
MALDI‐イメージング質量分析法を用いた多発性硬化症のプロテオミクスレベルのバイオマーカーと治療標的の特定

田中那美, 山下浩輝, 韮澤崇, 梶田遼, 田口勝敏, 田中雅樹, 近藤誉之, 辻雄大, 角田伸人, 池川雅哉

質量分析総合討論会講演要旨集, 67th 149, Apr 26, 2019
MALDI‐イメージング質量分析法を用いた実験的自己免疫性脳脊髄炎マウス中枢神経系組織プロテオーム解析による多発性硬化症のバイオマーカーと治療標的の特定

田中那美, 山下浩輝, 韮澤崇, 梶田遼, 田口勝敏, 田中雅樹, 近藤誉之, 辻雄大, 角田伸人, 池川雅哉

質量分析総合討論会講演要旨集, 67th 133, Apr 26, 2019
MALDI‐イメージング質量分析法とショットガンプロテオミクスを用いた拡張型心筋症モデルJ2N‐kハムスターの病態解析

新谷祈, 辻崇, 石田瑞希, 韮澤崇, 角田伸人, 植田初江, 升本英利, 湊谷謙司, 池川雅哉

質量分析総合討論会講演要旨集, 67th 204, Apr 26, 2019
W突然変異マウスのWhisker毛包における組織プロテオーム解析

小杉茉由佳, 木下和生, 韮澤崇, 梶田遼, 角田伸人, 池川雅哉

質量分析総合討論会講演要旨集, 67th 62, Apr 26, 2019
イメージング質量分析法とLC-TIMS-MS/MS法を用いた腎アミロイドーシスの病態解明

武笠結天, 韮澤崇, 梶田遼, RABANT Marion, VAN HUYEN Jean-Paul Duong, BRUNEVAL Patrick, 植田初江, 角田伸人, 池川雅哉

日本アミロイドーシス学会学術集会プログラム・抄録集, 7th, 2019
Imaging Mass Spectrometry to Study Neuropathology of Alzheimer's Disease

池川雅哉, 角田伸人, 宮坂知宏, 韮澤崇, 村山繁雄, 井原康夫

臨床病理 = The official journal of Japanese Society of Laboratory Medicine : 日本臨床検査医学会誌, 66(9) 1004-1009, Sep, 2018
薬剤性嗅覚障害モデルマウスにおけるメタボローム解析を用いた生体内代謝変動について

友野卓哉, 亀山大樹, 山本卓志, 藤分秀司, 角田伸人, 中邨智之, 池川雅哉

JSBMS Letters, 43(Supplement) 85-85, Aug 25, 2018
イメージングマススペクトロメトリー法を用いたホルマリン固定パラフィン包埋バイオプシー試料から腎アミロイドーシスの鑑別診断

武笠結天, 葛原由貴, 寺田恵, 韮澤崇, RABANT Marion, VAN HUYEN Jean‐Paul Duong, BRUNEVAL Patrick, 植田初江, 角田伸人, 池川雅哉

JSBMS Letters, 43(Supplement) 131-131, Aug 25, 2018
イメージング質量分析法を用いたアミロイドーシスの高深度プロテオミクス

池川雅哉, 角田伸人, 韮澤崇, 植田初江

JSBMS Letters, 43(Supplement) 39-39, Aug 25, 2018

Professional Memberships

日本認知症学会

Profile Information

Research Interests

Research Areas

Research History

Education

Papers

Misc.

Professional Memberships

Menu

Coauthors