Katsuaki Hoshino

Profile Information

Affiliation: Faculty of Medicine School of Medicine, Kagawa University

Degree: 博士（理学）(北海道大学)

J-GLOBAL ID: 201201076315573785
researchmap Member ID: 7000002871

Research Interests

Research Areas

Life sciences / Immunology /

Research History

Apr, 2012 - Present

Professor, Faculty of Medicine, Kagawa University
Apr, 2011 - Mar, 2012

Associate professor, Laboratory for Immune Regulation, WPI Immunology Frontier Research Center, Osaka University
Apr, 2003 - Apr, 2011

Research Scientist, Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, RIKEN Yokohama Institute
Apr, 2000 - Mar, 2003

Research Associate, Department of Host Defense, Research Associate, Research Institute for Microbial Diseases, Osaka University
Apr, 1999 - Mar, 2000

Research Fellow (Part-time), Department of Host Defense, Research Institute for Microbial Diseases, Osaka University
Apr, 1996 - Mar, 1999

Research fellow, Research Institute, International Medical Center of Japan

Education

Apr, 1995 - Mar, 1996

Department of Biological Sciences (Doctor course), Hokkaido University Graduate School of Science
Apr, 1993 - Mar, 1995

Division of Biological Sciences (Doctor course), Kanazawa University Graduate School of Natural Science & Technology
Apr, 1991 - Mar, 1993

Division of Biology (Master course), Kanazawa University Graduate School of Science
Apr, 1986 - Mar, 1990

Department of Biology, Faculty of Science, Shinshu University

Committee Memberships

Dec, 2015 - Present

評議員, 日本免疫学会

Papers

Immunomodulatory effects of D-allose on cytokine production by plasmacytoid dendritic cells

Kenjiro Takao, Makiko Suzuki, Ryo Miyazaki, Minoru Miyake, Kazuya Akimitsu, Katsuaki Hoshino

Biochemical and Biophysical Research Communications, 627 130-136, Oct 30, 2022
Transcription factor MafB-mediated inhibition of type I interferons in plasmacytoid dendritic cells

Hiroyuki Saiga, Masaki Ueno, Takashi Tanaka, Tsuneyasu Kaisho, Katsuaki Hoshino

International Immunology, 34(3) 159-172, Feb 23, 2022 Peer-reviewed
Galectin-9 deficiency exacerbates lipopolysaccharide-induced hypothermia and kidney injury

Keisuke Onishi, Hai Ying Fu, Tadashi Sofue, Atsushi Tobiume, Masahiro Moritoki, Hiroyuki Saiga, Mari Ohmura-Hoshino, Katsuaki Hoshino, Tetsuo Minamino

Clinical and Experimental Nephrology, 26(3) 226-233, Oct 26, 2021 Peer-reviewed
The mechanism of action of Spi-B in the transcriptional activation of the interferon-α4 gene.

Ryo Miyazaki, Hiroyuki Saiga, Takumi Kato, Takamitsu Bakoshi, Rina Senba, An Shintani, Makiko Suzuki, Kenjiro Takao, Izumi Sasaki, Akihiko Iizuka, Masanaka Sugiyama, Nana Iwami, Yuri Fukuda-Ohta, Hiroaki Hemmi, Takashi Tanaka, Minoru Miyake, Tsuneyasu Kaisho, Katsuaki Hoshino

Biochemical and biophysical research communications, 525(2) 477-482, Apr 30, 2020 Peer-reviewed
Cholera toxin B induces interleukin-1β production from resident peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome.

Takashi Orimo, Izumi Sasaki, Hiroaki Hemmi, Toshiya Ozasa, Yuri Fukuda-Ohta, Tomokazu Ohta, Mio Morinaka, Mariko Kitauchi, Takako Yamaguchi, Yayoi Sato, Takashi Tanaka, Katsuaki Hoshino, Kei-Ichi Katayama, Shinji Fukuda, Kensuke Miyake, Masahiro Yamamoto, Takashi Satoh, Koichi Furukawa, Etsushi Kuroda, Ken J Ishii, Kiyoshi Takeda, Tsuneyasu Kaisho

International immunology, 31(10) 657-668, Sep 18, 2019 Peer-reviewed
Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles.

Hisako Kayama, Masako Kohyama, Daisuke Okuzaki, Daisuke Motooka, Soumik Barman, Ryu Okumura, Masato Muneta, Katsuaki Hoshino, Izumi Sasaki, Wataru Ise, Hiroshi Matsuno, Junichi Nishimura, Tomohiro Kurosaki, Shota Nakamura, Hisashi Arase, Tsuneyasu Kaisho, Kiyoshi Takeda

Proceedings of the National Academy of Sciences of the United States of America, 115(33) 8418-8423, Aug 14, 2018 Peer-reviewed
Plasma Galectin-9 Concentrations in Normal and Diseased Condition.

Toshiro Niki, Koji Fujita, Hugo Rosen, Mitsuomi Hirashima, Tsutomu Masaki, Toshio Hattori, Katsuaki Hoshino

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 50(5) 1856-1868, 2018 Peer-reviewed
Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai, Hideki Sanjo, Tomohiko Ogawa, Yoshifumi Takeda, Kiyoshi Takeda, Shizuo Akira

JOURNAL OF IMMUNOLOGY, 197(7) 3749-3752, Oct, 2016 Peer-reviewed
Pillars Article: Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product. J. Immunol. 1999. 162: 3749-3752.

Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S

Journal of immunology (Baltimore, Md. : 1950), 197(7) 2563-2566, Oct, 2016 Peer-reviewed
Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis

Tomokazu Ohta, Masanaka Sugiyama, Hiroaki Hemmi, Chihiro Yamazaki, Soichiro Okura, Izumi Sasaki, Yuri Fukuda, Takashi Orimo, Ken J. Ishii, Katsuaki Hoshino, Florent Ginhoux, Tsuneyasu Kaisho

SCIENTIFIC REPORTS, 6 23505, Mar, 2016 Peer-reviewed
Antigen-specific cytotoxic T lymphocytes target airway CD103(+) and CD11b(+) dendritic cells to suppress allergic inflammation

N. J. Daniels, E. Hyde, S. Ghosh, K. Seo, K. M. Price, K. Hoshino, T. Kaisho, T. Okada, F. Ronchese

MUCOSAL IMMUNOLOGY, 9(1) 229-239, Jan, 2016 Peer-reviewed
Imaging of the cross-presenting dendritic cell subsets in the skin-draining lymph node

Masahiro Kitano, Chihiro Yamazaki, Akiko Takumi, Takashi Ikeno, Hiroaki Hemmi, Noriko Takahashi, Kanako Shimizu, Scott E. Fraser, Katsuaki Hoshino, Tsuneyasu Kaisho, Takaharu Okada

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(4) 1044-1049, Jan, 2016 Peer-reviewed
In Vivo Ablation of a Dendritic Cell Subset Expressing the Chemokine Receptor XCR1.

Hiroaki Hemmi, Katsuaki Hoshino, Tsuneyasu Kaisho

Methods in molecular biology (Clifton, N.J.), 1423 247-53, 2016 Peer-reviewed
Limitation of immune tolerance-inducing thymic epithelial cell development by Spi-B-mediated negative feedback regulation

Nobuko Akiyama, Miho Shinzawa, Maki Miyauchi, Hiromi Yanai, Ryosuke Tateishi, Yusuke Shimo, Daisuke Ohshima, Koichi Matsuo, Izumi Sasaki, Katsuaki Hoshino, Guoying Wu, Shintaro Yagi, Jun-ichiro Inoue, Tsuneyasu Kaisho, Taishin Akiyama

JOURNAL OF EXPERIMENTAL MEDICINE, 211(12) 2425-2438, Nov, 2014 Peer-reviewed
Single-Cell Imaging of Caspase-1 Dynamics Reveals an All-or-None Inflammasome Signaling Response

Ting Liu, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Koichi Shikada, Mai Yamagishi, Katsuaki Hoshino, Tsuneyasu Kaisho, Kiwamu Takemoto, Toshihiko Suzuki, Erina Kuranaga, Osamu Ohara, Masayuki Miura

CELL REPORTS, 8(4) 974-982, Aug, 2014 Peer-reviewed
Invariant NKT cells induce plasmacytoid dendritic cell (DC) cross-talk with conventional DCs for efficient memory CD8+ T cell induction

Kanako Shimizu, Miki Asakura, Jun Shinga, Yusuke Sato, Shuji Kitahara, Katsuaki Hoshino, Tsuneyasu Kaisho, Stephen P. Schoenberger, Taichi Ezaki, Shin-Ichiro Fujii

Journal of Immunology, 190(11) 5609-5619, Jun 1, 2013 Peer-reviewed
Critical Roles of a Dendritic Cell Subset Expressing a Chemokine Receptor, XCR1

Chihiro Yamazaki, Masanaka Sugiyama, Tomokazu Ohta, Hiroaki Hemmi, Eri Hamada, Izumi Sasaki, Yuri Fukuda, Takahiro Yano, Mikako Nobuoka, Takeshi Hirashima, Akihiko Iizuka, Katsuaki Sato, Takashi Tanaka, Katsuaki Hoshino, Tsuneyasu Kaisho

JOURNAL OF IMMUNOLOGY, 190(12) 6071-6082, Jun, 2013 Peer-reviewed
Enhanced Apoptosis by Disruption of the STAT3-I kappa B-zeta Signaling Pathway in Epithelial Cells Induces Sjogren's Syndrome-like Autoimmune Disease

Atsushi Okuma, Katsuaki Hoshino, Tomoyuki Ohba, Sawako Fukushi, Setsuya Aiba, Shizuo Akira, Masao Ono, Tsuneyasu Kaisho, Tatsushi Muta

IMMUNITY, 38(3) 450-460, Mar, 2013 Peer-reviewed
Spi-B is critical for plasmacytoid dendritic cell function and development

Izumi Sasaki, Katsuaki Hoshino, Takahiro Sugiyama, Chihiro Yamazaki, Takahiro Yano, Akihiko Iizuka, Hiroaki Hemmi, Takashi Tanaka, Masuyoshi Saito, Masanaka Sugiyama, Yuri Fukuda, Tomokazu Ohta, Katsuaki Sato, Akira Ainai, Tadaki Suzuki, Hideki Hasegawa, Noriko Toyama-Sorimachi, Hiroshi Kohara, Takashi Nagasawa, Tsuneyasu Kaisho

BLOOD, 120(24) 4733-4743, Dec, 2012 Peer-reviewed
The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells.

Takashi Kanaya, Koji Hase, Daisuke Takahashi, Shinji Fukuda, Katsuaki Hoshino, Izumi Sasaki, Hiroaki Hemmi, Kathryn A Knoop, Nachiket Kumar, Mayuko Sato, Tatsuro Katsuno, Osamu Yokosuka, Kiminori Toyooka, Kumiko Nakai, Ayako Sakamoto, Yuuki Kitahara, Toshi Jinnohara, Stephen J McSorley, Tsuneyasu Kaisho, Ifor R Williams, Hiroshi Ohno

Nature immunology, 13(8) 729-36, Jun 17, 2012 Peer-reviewed

Misc.

転写因子Spi-BによるInterferon-a4遺伝子の転写活性化メカニズム

宮嵜亮, 三宅実, 星野克明

日本口腔科学会雑誌, 68(2) 174-174, Jul, 2019
免疫学のABC(第11回) 自然免疫を活性化する受容体とそのリガンド

星野克明

分子リウマチ治療, 12(2) 96-99, Apr, 2019
形質細胞様樹状細胞の活性化を調節する分子機構の解明

星野克明

医科学応用研究財団研究報告, 33 373-376, Feb, 2016
自然免疫受容体による樹状細胞活性化メカニズムの解析

佐山浩二, 星野克明

西日本皮膚科, 77(3) 280-280, Jun, 2015
BAY11-7082は、ヒト樹状細胞由来の1型IFN産生を阻害する

宮本理恵, 伊藤量基, 尼川龍一, 安室秀樹, 片芝雄一, 尾形誠, 札谷直子, 嶋元佳子, 山崎千尋, 星野克明, 改正恒康, 福原資郎, 野村昌作

Cytometry Research, 24(Suppl.) 65-65, Jun, 2014
リアルタイム分泌イメージング法を用いたインフラマソーム活性化に伴うIL-1β分泌機序の解析

白崎善隆, 山岸舞, 鈴木信勇, 劉霆, 山口良文, 改正恒康, 星野克明, 三浦正幸, 小原收

日本細胞生物学会大会講演要旨集, 66回 161-161, May, 2014
膜蛋白質の分子機構と創薬ヒト由来膜内在性タンパク質の構造解析と創薬への展開をめざして

田辺弘明, 藤井佳史, 中村祥浩, 森慎滋, 篠田雄大, 石塚芳子, 新屋直子, 奥田賢一, 伊東夏織, 田嶋, 堀哲哉, 池田眞理子, 脇山素明, 寺田貴帆, 大沢登, 深田吉孝, 星野克明, 改正恒康, 日野智也, 小笠原諭, 村田武士, 岩田想, 岡田美紀, 部, 岩部真人, 山内敏正, 門脇孝, 羽藤正勝, 保坂俊彰, 木村友美, 谷, 白水美香子, 横山茂之

日本生化学会大会プログラム・講演要旨集, 86回 2S07a-5, Sep, 2013
【樹状細胞と免疫制御-新たな展開】CD8陽性樹状細胞サブセットの動的制御機構の解析

邊見弘明, 山崎千尋, 星野克明, 改正恒康

Cytometry Research, 22(1) 31-35, Mar, 2012
ヒト樹状細胞とマクロファージの機能 BDCA3+DCの発現するケモカインレセプターXCR1とNK細胞活性化能の解析(Importance of chemokines system between human BDCA3+ dendritic cells and NK cells in innate cytotoxic response)

伊藤量基, 宮本理恵, 山崎千尋, 星野克明, 改正恒康, 野村昌作

日本免疫学会総会・学術集会記録, 40 197-197, Nov, 2011
樹状細胞と免疫制御免疫疾患の解明に向けた新たな展開 CD8陽性樹状細胞の動的制御機構の解析

邊見弘明, 山崎千尋, 星野克明, 改正恒康

Cytometry Research, 21(Suppl.) 47-47, Jun, 2011
TLRシグナルによるI型インターフェロンの産生

星野克明, 改正恒康

臨床免疫・アレルギー科, 54(4) 465-471, Oct, 2010
【膠原病とインターフェロン】樹状細胞におけるpattern recognition receptorとI型インターフェロンの役割

星野克明, 改正恒康

炎症と免疫, 18(1) 38-43, Dec, 2009
自然炎症病原体センサーと内因性リガンドによる非感染性炎症反応の分子基盤核酸刺激による樹状細胞活性化を制御する分子機構

改正恒康, 田中貴志, 星野克明

日本生化学会大会プログラム・講演要旨集, 82回 4S2p-2, Sep, 2009
自然免疫から獲得免疫へのリンク TLRシグナルにおけるIKKファミリーの役割 IKKαを中心として

星野克明, 改正恒康

Annual Review免疫, 2008 61-69, Nov, 2007
【病原体センサーとそのシグナル伝達】TLRシグナルにおけるIKKαの役割

星野克明, 改正恒康

炎症と免疫, 15(5) 602-608, Aug, 2007
樹状細胞サブセットと機能 Toll-like receptor 7/9刺激樹状細胞によるI型インターフェロン産生誘導におけるIκBキナーゼ-αの機能

星野克明, 杉山孝弘, 松本満, 田中貴志, 審良静男, 改正恒康

日本免疫学会総会・学術集会記録, 36 212-212, Nov, 2006
マウス樹状細胞における遺伝子発現の解析(Gene expression profiles of mouse dendritic cell subsets)

斎藤万寿吉, 星野克明, 杉山孝弘, 田中貴志, 坪井良治, 改正恒康

東京医科大学雑誌, 64(3) 294-304, May, 2006
細菌由来リポペプチドはtoll-like receptor2を介してマウスケラチノサイトにβ-defensin3を誘導する

澄川靖之, 浅田秀夫, 星野克明, 小豆澤宏明, 片山一朗, 審良静男, 板見智

日本研究皮膚科学会年次学術大会・総会プログラム, 31回 99-99, Apr, 2006
Flt3L誘導骨髄樹状細胞におけるToll-like receptor 3を介するシグナル伝達機構の解析

星野克明, 杉山孝弘, 田中貴志, 審良静男, 改正恒康

日本免疫学会総会・学術集会記録, 35 47-47, Nov, 2005
2本鎖RNA(polyadenylic-polyuridilic acid)によるマウス樹状細胞活性化機構

杉山孝弘, 星野克明, 田中貴志, 改正恒康

日本免疫学会総会・学術集会記録, 35 153-153, Nov, 2005

Teaching Experience

Professional Memberships

Research Projects

形質細胞様樹状細胞に選択的に発現している膜受容体チロシンキナーゼの機能解析

科学研究費補助金基盤研究(C), 日本学術振興会, Apr, 2014 - Mar, 2017

星野克明
形質細胞様樹状細胞特異的遺伝子改変マウスによる樹状細胞の動態制御機構の解明

科学研究費補助金基盤研究(C), 日本学術振興会, Apr, 2010 - Mar, 2013

星野克明
活性化樹状細胞に発現するTh2細胞分化誘導因子の同定と解析

科学研究費補助金若手研究(B), 日本学術振興会, Apr, 2003 - Mar, 2006

星野克明
樹状細胞の成熟に関与する分子群の同定と解析研

科学研究費補助金若手研究(B), 日本学術振興会, Apr, 2001 - Mar, 2003

星野克明

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