Haruyuki Imaohji

Profile Information

Affiliation: Faculty of Medicine, Kagawa University

Degree: 医学博士(徳島大学)

ORCID ID: https://orcid.org/0000-0003-0196-2247
J-GLOBAL ID: 201201097954879329
researchmap Member ID: 7000002874

Research Interests

Research Areas

Life sciences / Bacteriology /

Research History

Apr, 2017 - Present

Faculty of Medicine, Kagawa University
Apr, 2012 - Mar, 2017

Faculty of Medicine, Kagawa University
Apr, 2007 - Mar, 2012

Institute of Health Biosciences The University of Tokushima Graduate School, The University of Tokushima
Jun, 1997 - Mar, 2007

Faculty of Medicine, The University of Tokushima

Education

Apr, 1995 - Mar, 1997

Graduate School of Engineering, The University of Tokushima

Papers

Partially hydrolyzed guar gum alleviates hepatic steatosis and alters specific gut microbiota in a murine liver injury model

Takayuki Fujii, Haruyuki Nakayama-Imaohji, Aya Tanaka, Hiroto Katami, Kazuya Tanaka, Yoichi Chiba, Machi Kawauchi, Masaki Ueno, Tomomi Kuwahara, Ryuichi Shimono

Pediatric Surgery International, Sep 12, 2022
Inactivation of human norovirus by chlorous acid water, a novel chlorine-based disinfectant.

Hisataka Goda, Haruyuki Nakayama-Imaohji, Hitoshi Yamaoka, Ayano Tada, Tamiko Nagao, Tomohiko Fujisawa, A Hajime Koyama, Tomomi Kuwahara

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Oct 9, 2021 Peer-reviewed
The Human Gut Microbe Bacteroides thetaiotaomicron Suppresses Toxin Release from Clostridium difficile by Inhibiting Autolysis.

Miad Elahi, Haruyuki Nakayama-Imaohji, Masahito Hashimoto, Ayano Tada, Hisashi Yamasaki, Tamiko Nagao, Tomomi Kuwahara

Antibiotics (Basel, Switzerland), 10(2), Feb 15, 2021 Peer-reviewed
Microbiome analysis of contact lens care solutions and tear fluids of contact lens wearers: Possible involvement of streptococcal antigens in allergic symptoms related to contact lens wear.

Fumika Hotta, Hiroshi Eguchi, Haruyuki Nakayama-Imaohji, Tomomi Kuwahara, Ayano Tada, Hirofumi Yagi, Yoshikazu Shimomura, Shunji Kusaka

International journal of molecular medicine, 46(4) 1367-1376, Oct, 2020 Peer-reviewed
Effect of thymoquinone on Fusobacterium nucleatum‑associated biofilm and inflammation.

Ayano Tada, Haruyuki Nakayama-Imaohji, Hisashi Yamasaki, Miad Elahi, Tamiko Nagao, Hirofumi Yagi, Masao Ishikawa, Koji Shibuya, Tomomi Kuwahara

Molecular medicine reports, 22(2) 643-650, Aug, 2020 Peer-reviewed
Presence of Acanthamoeba and diversified bacterial flora in poorly maintained contact lens cases.

Dai Miyazaki, Hiroshi Eguchi, Tomomi Kuwahara, Haruyuki Nakayama-Imaohji, Masamaru Inaba, Motozumi Itoi, Kiichi Ueda, Yuichi Ohashi, Kazushige Sado, Satoshi Mizutani, Hitoshi Miyamoto, Shin-Ichi Sasaki, Yumiko Shimizu, Yoshitsugu Inoue

Scientific reports, 10(1) 12595-12595, Jul 28, 2020 Peer-reviewed
非結核性抗酸菌に対する亜塩素酸水(HClO2)製剤の不活化効果

山岡徹, 今大路治之, 多田彩乃, 合田学剛, 桑原知巳

感染症学雑誌, 94(臨増) 279-279, Mar, 2020
【小児外科領域における感染症-基礎編】腸内細菌叢と抗菌薬との関連

田中彩, 下野隆一, 今大路治之, 桑原知巳

小児外科, 52(1) 45-49, Jan, 2020
Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota.

Fujii T, Chiba Y, Nakayama-Imaohji H, Onishi S, Tanaka A, Katami H, Kaji T, Ieiri S, Miki T, Ueno M, Kuwahara T, Shimono R

Journal of pediatric surgery, 54(12) 2514-2519, Dec, 2019 Peer-reviewed
Genetic diversity and persistent colonization of Enterococcus faecalis on ocular surfaces

Todokoro D, Eguchi H, Suzuki T, Suzuki M, Nakayama-Imaohji H, Kuwahara T, Nomura T, Tomita H, Akiyama H

Jpn J Ophthalmology, 15(doi: 10.1007/s10384-018-0630-5), Oct, 2018 Peer-reviewed
Ethanolamine utilization supports Clostridium perfringens growth in infected tissues.

Yagi H, Nakayama-Imaohji H, Nariya H, Tada A, Yamasaki H, Ugai H, Elahi M, Ono T, Kuwahara T

Microbial pathogenesis, 119 200-207, Jun, 2018 Peer-reviewed
L-histidine augments the oxidative damage against Gram-negative bacteria by hydrogen peroxide

Tamiko Nagao, Haruyuki Nakayama-Imaohji, Miad Elahi, Ayano Tada, Emika Toyonaga, Hisashi Yamasaki, Katsuichiro Okazaki, Hirokazu Miyoshi, Koichiro Tsuchiya, Tomomi Kuwahara

International Journal of Molecular Medicine, 41(5) 2847-2854, May 1, 2018 Peer-reviewed
L-histidine augments the oxidative damage against Gram-negative bacteria by hydrogen peroxide

Tamiko Nagao, Haruyuki Nakayama-Imaohji, Miad Elahi, Ayano Tada, Emika Toyonaga, Hisashi Yamasaki, Katsuichiro Okazaki, Hirokazu Miyoshi, Koichiro Tsuchiya, Tomomi Kuwahara

International Journal of Molecular Medicine, 41(5) 2847-2854, May 1, 2018 Peer-reviewed
Characterization of a recombinant Bacteroides fragilis sialidase expressed in Escherichia coli

Takaaki Yamamoto, Hideyo Ugai, Haruyuki Nakayama-Imaohji, Ayano Tada, Miad Elahi, Hitoshi Houchi, Tomomi Kuwahara

Anaerobe, 50 69-75, Apr 1, 2018 Peer-reviewed
D-Tagatose inhibits the growth and biofilm formation of Streptococcus mutans

Khaleque Hasibul, Haruyuki Nakayama-Imaohji, Masahito Hashimoto, Hisashi Yamasaki, Takaaki Ogawa, Junpei Waki, Ayano Tada, Saori Yoneda, Masaaki Tokuda, Minoru Miyake, Tomomi Kuwahara

Molecular Medicine Reports, 17(1) 843-851, Jan 1, 2018 Peer-reviewed
Acute keratoconjunctivitis due to contamination of contact lens care solution with histamine-producing Raoultella species: A case report

Hiroshi Eguchi, Fumika Hotta, Tomomi Kuwahara, Haruyuki Nakayama-Imaohji, Shunji Kusaka, Yoshikazu Shimomura

Medicine (United States), 96(50) e9310, Dec 1, 2017 Peer-reviewed
Diagnostic approach to ocular infections using various techniques from conventional culture to next-generation sequencing analysis

Hiroshi Eguchi, Fumika Hotta, Tomomi Kuwahara, Haruyuki Imaohji, Chika Miyazaki, Miou Hirose, Shunji Kusaka, Masahiko Fukuda, Yoshikazu Shimomura

Cornea, 36 S46-S52, Nov 1, 2017 Peer-reviewed
TLR2-stimulating contaminants in glycoconjugate fractions prepared from Bacteroides fragilis

Masahito Hashimoto, Junpei Waki, Haruyuki Nakayama-Imaohji, Mami Ozono, Shuhei Hashiguchi, Tomomi Kuwahara

INNATE IMMUNITY, 23(5) 449-458, Jul, 2017 Peer-reviewed
Microbicidal effects of weakly acidified chlorous acid water against feline calicivirus and Clostridium difficile spores under protein-rich conditions

Hisataka Goda, Hitoshi Yamaoka, Haruyuki Nakayama-Imaohji, Hiroyuki Kawata, Isanori Horiuchi, Yatsuka Fujita, Tamiko Nagao, Ayano Tada, Atsushi Terada, Tomomi Kuwahara

PLOS ONE, 12(5) e0176718, May, 2017 Peer-reviewed
Identification of a New Virulent Clade in Enterohemorrhagic Escherichia coli O26: H11/H-Sequence Type 29

Nozomi Ishijima, Ken-ichi Lee, Tomomi Kuwahara, Haruyuki Nakayama-Imaohji, Saori Yoneda, Atsushi Iguchi, Yoshitoshi Ogura, Tetsuya Hayashi, Makoto Ohnishi, Sunao Iyoda

SCIENTIFIC REPORTS, 7 43136, Feb, 2017 Peer-reviewed

Misc.

次世代シークエンス技術を用いた周術期の眼表面菌叢解析

堀田芙美香, 江口洋, 桑原知巳, 今大路治之, 日下俊次

日本眼科学会雑誌, 123(臨増) 225-225, Mar, 2019
Corynebacterium oculiの薬剤感受性

堀田芙美香, 江口洋, 日下俊次, 福田昌彦, 下村嘉一, 今大路治之, 桑原知巳, Bernard Kathryn, Vandamme Peter

日本眼科学会雑誌, 121(臨増) 198-198, Mar, 2017
Spore purification of mouse gut derived non-culturable bacterium

Motoo Suzuki, Haruyuki Imaohji, Tomomi Kuwahara

GENES & GENETIC SYSTEMS, 89(6) 328-328, Dec, 2014
Mariner-based transposon mutagenesis for Bacteroides species

Minoru Ichimura, Keiko Uchida, Haruyuki Nakayama-Imaohji, Hideki Hirakawa, Tomoyo Tada, Hidetoshi Morita, Koji Yasutomo, Katsuichiro Okazaki, Tomomi Kuwahara

JOURNAL OF BASIC MICROBIOLOGY, 54(6) 558-567, Jun, 2014 Peer-reviewed
Bronchiolitis and bacteraemia caused by Burkholderia gladioli in a non-lung transplantation patient

O. Imataki, N. Kita, H. Nakayama-Imaohji, J. I. Kida, T. Kuwahara, M. Uemura

New Microbes and New Infections, 2(6) 175-176, 2014 Peer-reviewed
Effect of Kampo medicine "Dai-kenchu-to" on microbiome in the intestine of the rats with fast stress

Kozo Yoshikawa, Mitsuo Shimada, Tomomi Kuwahara, Hideki Hirakawa, Nobuhiro Kurita, Hirohiko Sato, Tohru Utsunomiya, Takashi Iwata, Tomohiko Miyatani, Jun Higashijima, Hideya Kashihara, Chie Takasu, Noriko Matsumoto, Haruyuki Nakayama-Imaohji

Journal of Medical Investigation, 60(3-4) 221-227, 2013 Peer-reviewed
PhoB Regulates the Survival of Bacteroides fragilis in Peritoneal Abscesses

Shin Wakimoto, Haruyuki Nakayama-Imaohji, Minoru Ichimura, Hidetoshi Morita, Hideki Hirakawa, Tetsuya Hayashi, Koji Yasutomo, Tomomi Kuwahara

PLOS ONE, 8(1) e53829, Jan, 2013 Peer-reviewed
Characterization of a gene cluster for sialoglycoconjugate utilization in Bacteroides fragilis

Haruyuki Nakayama-Imaohji, Minoru Ichimura, Tomoya Iwasa, Natsumi Okada, Yoshinari Ohnishi, Tomomi Kuwahara

Journal of Medical Investigation, 59(1-2) 79-94, Feb, 2012 Peer-reviewed
Effects of indole-3-carbinol and phenethyl isothiocyanate on bile and pancreatic juice excretion in rats

Hiroki Ishibashi, Tomomi Kuwahara, Haruyuki Nakayama-Imaohji, Yoshinari Ohnishi, Hiroki Mori, Mitsuo Shimada

Journal of Medical Investigation, 59(3-4) 246-252, 2012 Peer-reviewed
The Lifestyle of the Segmented Filamentous Bacterium: A Non-Culturable Gut-Associated Immunostimulating Microbe Inferred by Whole-Genome Sequencing

Tomomi Kuwahara, Yositoshi Ogura, Kenshiro Oshima, Ken Kurokawa, Tadasuke Ooka, Hideki Hirakawa, Takehiko Itoh, Haruyuki Nakayama-Imaohji, Minoru Ichimura, Kikuji Itoh, Chieko Ishifune, Yoichi Maekawa, Koji Yasutomo, Masahira Hattori, Tetsuya Hayashi

DNA RESEARCH, 18(4) 291-303, Aug, 2011 Peer-reviewed
Efficient Electrotransformation of Bacteroides fragilis

Minoru Ichimura, Haruyuki Nakayama-Imaohji, Shin Wakimoto, Hidetoshi Morita, Tetsuya Hayashi, Tomomi Kuwahara

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 76(10) 3325-3332, May, 2010 Peer-reviewed
眼科領域で分離されるCorynebacteriumの薬剤耐性化状況の全国調査

江口洋, 桑原知巳, 今大路治之

感染症学雑誌, 83(6) 732-732, Nov, 2009
Identification of the Site-Specific DNA Invertase Responsible for the Phase Variation of SusC/SusD Family Outer Membrane Proteins in Bacteroides fragilis

Haruyuki Nakayama-Imaohji, Hideki Hirakawa, Minoru Ichimura, Shin Wakimoto, Satoru Kuhara, Tetsuya Hayashi, Tomomi Kuwahara

JOURNAL OF BACTERIOLOGY, 191(19) 6003-6011, Oct, 2009 Peer-reviewed
眼結膜由来のコリネバクテリウムにおけるフルオロキノロン感受性

桑原知巳, 江口洋, 今大路治之

感染症学雑誌, 83(3) 317-317, May, 2009
Bacteroides fragilis のDNA逆位による外膜 vesicle 形成の制御

今大路治之, 弘田克彦, 三宅洋一郎, 桑原知巳

日本細菌学雑誌, 62(1) 135-135, Feb 25, 2007

Presentations

Raoultella ornithinolyticaにおけるhistamine産生は酸素ストレス耐性に関与する

第87回日本細菌学会総会, 2014
Raoultella ornithinolyticaにおけるhistamine産生と酸素ストレス耐性

第66回日本細菌学会中国・四国支部総会, 2013
腸管内常在菌がClostridium difficileの病原性に与える影響

第83回日本感染症学会西日本地方会学術集会, 2013
ウェルシュ菌のエタノールアミン利用能と病原性

第６５回日本細菌学会中国・四国支部総会, 2012
Bacteroides thetaiotaomicronにおけるマリナートランスポゾン挿入変異ライブラリーの開発

第35回日本分子生物学会年会, 2012
腸管内常在菌によるClostridium difficileの病原性抑制機構

第35回日本分子生物学会年会, 2012
Bacteroides fragilisの外膜空胞形成は膜ストレスに応答したDNA逆位によって制御される

第35回日本分子生物学会年会, 2012

Professional Memberships

Research Projects

腸筋相関を軸としたフェカリバクテリウム菌の抗サルコペニア効果の検証

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

今大路治之, 桑原知巳
機能性プロバイオティクスによる疾患治療と予防への挑戦

科学研究費助成事業挑戦的研究(萌芽), 日本学術振興会, Jun, 2022 - Mar, 2024

桑原知巳, 今大路治之
漢方薬による腸内細菌叢を介した抗癌薬関連毒性予防効果の機序解明と支持療法への応用

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

西内崇将, 桑原知巳, 今大路治之
加齢性骨格筋減少症における腸内フローラ機能の役割

科学研究費助成事業基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2023

桑原知巳, 豊田敦, 刑部有希, 世良泰, 川崎淨教, 高見英人, 今大路治之
乳幼児腸内細菌叢の再構成プロセスに関する研究

科学研究費助成事業基盤研究(B), 日本学術振興会, Apr, 2019 - Mar, 2022

今大路治之, 桑原知巳, 高見英人, 豊田敦, 下野隆一, 田中彩
Regulation and physiological significance of histamine production in Raoultella ornithinolytica

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Imaohji Haruyuki
Analysis of physiological significance of the diversity and the phase-variable regulation of the capsular polysaccharides in Bacteroides

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

NAKAYAMA HARUYUKI, KUWAHARA Tomomi
Analysis of the phase-variable regulation of the capsular polysaccharides in the human symbiont Bacteroides

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2010 - 2011

NAKAYAMA Haruyuki
フラジリス菌の表層抗原性を制御する部位特異的組換え酵素の同定および発現解析

科学研究費助成事業若手研究(B), 日本学術振興会, 2006 - 2007

中山治之
フラジリス菌における複合糖鎖分解遺伝子の病原性発現における役割

科学研究費助成事業若手研究(B), 日本学術振興会, 2003 - 2005

中山治之

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