J-GLOBAL         Last updated: Dec 28, 2019 at 17:00
Kumamoto University

Research Areas


Academic & Professional Experience

Apr 2019
Assistant Professor, Department of Ophthalmology, Kumamoto University
Apr 2016
Mar 2019
Senior research scientist, Prof. Suda’s lab, National University of Singapore
Apr 2012
Apr 2016
Assistant Professor, Department of Ophthalmology, University of Fukui
Apr 2011
Mar 2012
Medical doctor, Department of ophthalmology, Kumamoto Chuo Hospital
Apr 2006
Mar 2007
Medical doctor, Department of ophthalmology, Kumamoto University
May 2004
Mar 2006
Resident, Iizuka Hospital


Apr 2007
Mar 2011
Graduate School of Medical Sciences, Kumamoto University
Apr 1998
Mar 2004
School of Medicine, Kumamoto University

Awards & Honors

Kowa Travel Grant, The Association for Research in Vision and Ophthalmology

Published Papers

High mitochondrial mass is associated with reconstitution capacity and quiescence of hematopoietic stem cells.
Takihara Y, Nakamura-Ishizu A, Tan DQ, Fukuda M, Matsumura T, Endoh M, Arima Y, Chin DWL, Umemoto T, Hashimoto M, Mizuno H, Suda T.
Blood Advances   3 2323-2327   2019   [Refereed]
Thrombopoietin metabolically primes hematopoietic stem cells to megakaryocyte-lineage differentiation.
Nakamura-Ishizu A, Matsumura T, Stumpf PS, Umemoto T, Takizawa H, Takihara Y, O'Neil A, Majeed ABBA, MacArthur BD, Suda T.
Cell Rep.   25 1772-1785   2018   [Refereed]
Prospective cohort study of corneal endothelial cell loss after Baerveldt glaucoma implantation.
Iwasaki K, Arimura S, Takihara Y, Takamura Y, Inatani M.
PLoS One   13 e0201342   2018   [Refereed]
Culture systems of dissociated mouse and human pluripotent stem cell-derived retinal ganglion cells purified by two-step immunopanning.
Kobayashi W, Onishi A, Tu HY, Takihara Y, Matsumura M, Tsujimoto K, Inatani M, Nakazawa T, Takahashi M.
Invest Ophthalmol Vis Sci.   59 776-787   2018   [Refereed]
Effect of microtubule disruption on dynamics of acidic organelles in the axons of primary cultured retinal ganglion cells.
Miyake S, Takihara Y, Yokota S, Takamura Y, Inatani M.
Curr Eye Res.   43 77-83   2018   [Refereed]
Comparison of subconjunctival scarring after microincision vitrectomy surgery using 20-, 23-, 25- and 27-gauge systems in rabbits.
Gozawa M, Takamura Y, Miyake S, Iwasaki K, Arimura S, Takihara Y, Inatani M.
Acta Ophthalmol.   95 e602-609   2017   [Refereed]
Evaluation of bleb fluid after Baerveldt glaucoma implantation using magnetic resonance imaging.
Iwasaki K, Kanamoto M, Takihara Y, Arimura S, Takamura Y, Kimura H, Inatani M.
Sci Rep.   7 11345   2017   [Refereed]
Circumpapillary retinal nerve fiber layer thickness, anterior lamina cribrosa depth, and lamina cribrosa thickness in neovascular glaucoma secondary to proliferative diabetic retinopathy: a cross-sectional study.
Yokota S, Takihara Y, Takamura Y, Inatani M.
BMC Ophthalmol.   17 57   2017   [Refereed]
Prospective observational study of conjunctival scarring after phacoemulsification.
Gozawa M, Takamura Y, Miyake S, Yokota S, Sakashita M, Arimura S, Takihara Y, Inatani M.
Acta Ophthalmol.   94 e541-549   2016   [Refereed]
Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration.
Shim MS, Takihara Y, Kim KY, Iwata T, Yue BY, Inatani M, Weinreb RN, Perkins GA, Ju WK.
Sci Rep.   6 33830   2016   [Refereed]
Randomized clinical trial for early postoperative complications of Ex-PRESS implantation versus trabeculectomy: complications postoperatively of Ex-PRESS versus trabeculectomy study (CPETS).
Arimura S, Takihara Y, Miyake S, Iwasaki K, Gozawa M, Matsumura T, Tomomatsu T, Takamura Y, Inatani M.
Sci Rep.   6 26080   2016   [Refereed]
The relationship between self-reported habitual exercise and visual field defect progression: a retrospective cohort study.
Yokota S, Takihara Y, Kimura K, Takamura Y, Inatani M.
BMC Ophthalmol.   16 147   2016   [Refereed]
Comparative study of combined bevacizumab/targeted photocoagulation vs bevacizumab alone for macular oedema in ischaemic branch retinal vein occlusions.
Tomomatsu Y, Tomomatsu T, Takamura Y, Gozawa M, Arimura S, Takihara Y, Inatani M.
Acta Ophthalmol.   94 e225-230   2016   [Refereed]
In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS.
Takihara Y, Inatani M, Eto K, Inoue T, Kreymerman A, Miyake S, Ueno S, Nagaya M, Nakanishi A, Iwao K, Takamura Y, Sakamoto H, Satoh K, Kondo M, Sakamoto T, Goldberg JL, Nabekura J, Tanihara H.
Proc Natl Acad Sci U S A.   112 10515-10520   2015   [Refereed]
Limbus- versus fornix-based trabeculectomy for open-angle glaucoma eyes with prior ocular surgery: the Collaborative Bleb-Related Infection Incidence and Treatment Study.
Yokota S, Takihara Y, Inatani M.
Sci Rep.   5 9290   2015   [Refereed]
Altered transport velocity of axonal mitochondria in retinal ganglion cells after laser-induced axonal injury in vitro.
Yokota S, Takihara Y (corresponding author), Arimura S, Miyake S, Takamura Y, Yoshimura N, Inatani M.
Invest Ophthalmol Vis Sci.   56 8019-8025   2015   [Refereed]
Vitreous and aqueous concentrations of brimonidine following topical application of brimonidine tartrate 0.1% ophthalmic solution in humans.
Takamura Y, Tomomatsu T, Matsumura T, Takihara Y, Kozai S, Arimura S, Yokota S, Inatani M.
J Ocul Pharmacol Ther.   31 282-285   2015   [Refereed]
Correlation between central retinal thickness after successful macular hole surgery and visual outcome.
Takamura Y, Tomomatsu T, Matsumura T, Arimura S, Gozawa M, Takihara Y, Inatani M.
Jpn J Ophthalmol.   59 394-400   2015   [Refereed]
Changes in matrix metalloproteinases in diabetes patients' tears after vitrectomy and the relationship with corneal epithelial disorder.
Matsumura T, Takamura Y, Tomomatsu T, Arimura S, Gozawa M, Takihara Y, Inatani M.
Invest Ophthalmol Vis Sci.   56 3559-3564   2015   [Refereed]
Determinants of anterior chamber angle narrowing after mydriasis in the patients with cataract.
Arimura S, Takamura Y, Takihara Y, Matsumura T, Tomomatsu T, Inatani M.
Graefes Arch Clin Exp Ophthalmol.   253 307-312   2015   [Refereed]
The effect of photocoagulation in ischemic areas to prevent recurrence of diabetic macular edema after intravitreal bevacizumab injection.
Takamura Y, Tomomatsu T, Matsumura T, Arimura S, Gozawa M, Takihara Y, Inatani M.
Invest Ophthalmol Vis Sci.   55 4741-4746   2014   [Refereed]
Large capsulorhexis with implantation of a 7.0 mm optic intraocular lens during cataract surgery in patients with diabetes mellitus.
Takamura Y, Tomomatsu T, Yokota S, Matsumura T, Takihara Y, Inatani M.
J Cataract Refract Surg.   40 1850-1856   2014   [Refereed]
Long-term outcomes and prognostic factors for trabeculectomy with mitomycin C in eyes with uveitic glaucoma: a retrospective cohort study.
Iwao K, Inatani M, Seto T, Takihara Y, Ogata-Iwao M, Okinami S, Tanihara H.
J Glaucoma.   23 88-94   2014   [Refereed]
Trabeculectomy for open-angle glaucoma in phakic eyes vs in pseudophakic eyes after phacoemulsification: a prospective clinical cohort study.
Takihara Y, Inatani M, Ogata-Iwao M, Kawai M, Inoue T, Iwao K, Tanihara H.
JAMA Ophthalmol.   132 69-76   2014   [Refereed]
Prognostic factors in trabeculectomy with mitomycin C having history of previous glaucoma surgery.
Awai-Kasaoka N, Inoue T, Inatani M, Takihara Y, Ogata-Iwao M, Tanihara H.
Jpn J Ophthalmol.   57 514-519   2013   [Refereed]
Anterior capsule contraction and flare intensity in the early stages after cataract surgery in eyes with diabetic retinopathy.
Takamura Y, Tomomatsu T, Arimura S, Tomomatsu Y, Matsumura T, Takihara Y, Inatani M.
J Cataract Refract Surg.   39 716-721   2013   [Refereed]
Frequency and risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy.
Goto A, Inatani M, Inoue T, Awai-Kasaoka N, Takihara Y, Ito Y, Fukushima M, Tanihara H.
J Glaucoma.   22 572-576   2013   [Refereed]
Aldose reductase inhibitor counteracts the enhanced expression of matrix metalloproteinase-10 and improves corneal wound healing in galactose-fed rats.
Takamura Y, Matsumoto T, Tomomatsu T, Matsumura T, Takihara Y, Inatani M.
Mol Vis.   19 2477-2486   2013   [Refereed]
A prospective comparison between trabeculectomy with mitomycin C and phacotrabeculectomy with mitomycin C.
Ogata-Iwao M, Inatani M, Takihara Y, Inoue T, Iwao K, Tanihara H.
Acta Ophthalmol.   91 e500-501   2013   [Refereed]
Relationship between lenticular power and refractive error in children with hyperopia.
Tomomatsu T, Kono S, Arimura S, Tomomatsu Y, Matsumura T, Takihara Y, Inatani M, Takamura Y.
Clin Ophthalmol.   7 601-606   2013   [Refereed]
Prognostic risk factors for failure of trabeculectomy with mitomycin C after vitrectomy.
Inoue T, Inatani M, Takihara Y, Awai-Kasaoka N, Ogata-Iwao M, Tanihara H.
Jpn J Ophthalmol.   56 464-469   2012   [Refereed]
A prospective study of postoperative aqueous flare in trabeculectomy alone versus phacotrabeculectomy.
Inatani M, Ogata-Iwao M, Takihara Y, Iwao K, Inoue T, Kasaoka N, Tanihara H.
Nippon Ganka Gakkai Zasshi.   116 856-861   2012   [Refereed]
Impact of phacoemulsification on failure of trabeculectomy with mitomycin C.
Awai-Kasaoka N, Inoue T, Takihara Y, Kawaguchi A, Inatani M, Ogata-Iwao M, Tanihara H.
J Cataract Refract Surg.   38 419-424   2012   [Refereed]
Dynamic imaging of axonal transport in living retinal ganglion cells in vitro.
Takihara Y, Inatani M, Hayashi H, Adachi N, Iwao K, Inoue T, Iwao M, Tanihara H.
Invest Ophthalmol Vis Sci.   52 3039-3045   2011   [Refereed]
Trabeculectomy with mitomycin for open-angle glaucoma in phakic vs pseudophakic eyes after phacoemulsification.
Takihara Y, Inatani M, Seto T, Iwao K, Iwao M, Inoue T, Kasaoka N, Murakami A, Futa R, Tanihara H.
Arch Ophthalmol.   129 152-157   2011   [Refereed]
Combined intravitreal bevacizumab and trabeculectomy with mitomycin C versus trabeculectomy with mitomycin C alone for neovascular glaucoma.
Takihara Y, Inatani M, Kawaji T, Fukushima M, Iwao K, Iwao M, Tanihara H.
J Glaucoma.   20 196-201   2011   [Refereed]
Heparan sulfate regulates intraretinal axon pathfinding by retinal ganglion cells.
Ogata-Iwao M, Inatani M, Iwao K, Takihara Y, Nakaishi-Fukuchi Y, Irie F, Sato S, Furukawa T, Yamaguchi Y, Tanihara H.
Invest Ophthalmol Vis Sci.   52 6671-6679   2011   [Refereed]
Restricted post-trabeculectomy bleb formation by conjunctival scarring.
Iwao K, Inatani M, Ogata-Iwao M, Takihara Y, Tanihara H.
Graefes Arch Clin Exp Ophthalmol.   247 1095-1101   2009   [Refereed]
Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-β2 signaling.
Iwao K, Inatani M, Matsumoto Y, Ogata-Iwao M, Takihara Y, Irie F, Yamaguchi Y, Okinami S, Tanihara H.
J Clin Invest.   119 1997-2008   2009   [Refereed]
Trabeculectomy with mitomycin C for neovascular glaucoma: prognostic factors for surgical failure.
Takihara Y, Inatani M, Fukushima M, Iwao K, Iwao M, Tanihara H.
Am J Ophthalmol.   147 912-918   2009   [Refereed]
眼科手術   20 439-442   2007   [Refereed]


Management of neovascular glaucoma.
Inatani M, Takihara Y, Takamura Y.
Expert Rev Ophthalmol.   9 33-42   2014
Frontiers in Glaucoma   8 202-209   2007

Books etc

Neuroprotection and Neuroregeneration for Retinal Diseases. Axonal transport.
Takihara Y, Inatani M. (Part:Joint Work)
Springer   2014   ISBN:978-4-431-54965-9