2021年5月25日
Mitochondria transfer from early stages of erythroblasts to their macrophage niche via tunnelling nanotubes
British Journal of Haematology
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 193
- 号
- 6
- 開始ページ
- 1260
- 終了ページ
- 1274
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/bjh.17531
- 出版者・発行元
- Wiley
Adult erythropoiesis entails a series of well-coordinated events that produce mature red blood cells. One of such events is the mitochondria clearance that occurs cell-autonomously via autophagy-dependent mechanisms. Interestingly, recent studies have shown mitochondria transfer activities between various cell types. In the context of erythropoiesis, macrophages are known to interact closely with the early stages of erythroblasts to provide a specialized niche, termed erythroblastic islands (EBI). However, whether mitochondria transfer can occur in the EBI niche has not been explored. Here, we report that mitochondria transfer in the EBI niche occurs in vivo. We observed mitochondria transfer activities from the early stages of erythroblasts to macrophages in the reconstituted in vitro murine EBI via different modes, including tunnelling nanotubes (TNT). Moreover, we demonstrated that Wiskott-Aldrich syndrome protein (WASp) in macrophages mediates TNT formation and mitochondria transfer via the modulation of F-actin filamentation, thus promoting mitochondria clearance from erythroid cells, to potentially enhance their differentiation. Taken together, our findings provide novel insight into the mitochondria clearance machineries that mediate erythroid maturation.
- リンク情報
- ID情報
-
- DOI : 10.1111/bjh.17531
- ISSN : 0007-1048
- eISSN : 1365-2141
- PubMed ID : 34036571