柴田玲 (Rei Shibata) - マイポータル

基本情報

所属: 名古屋大学大学院医学系研究科寄附講座（医）先進循環器治療学寄附講座特任教授

J-GLOBAL ID: 201201075569640613
researchmap会員ID: 7000002982

研究分野

ライフサイエンス / 循環器内科学 /

経歴

2020年4月 - 現在

名古屋大学, 大学院医学系研究科寄附講座（医）先進循環器治療学寄附講座, 特任教授
2019年2月 - 2020年3月

名古屋大学, 大学院医学系研究科寄附講座（医）先進循環器治療学寄附講座, 寄附講座教授
2018年6月 - 2019年1月

名古屋大学, 大学院医学系研究科寄附講座（医）先進循環器治療学寄附講座, 寄附講座准教授
2015年11月 - 2018年5月

名古屋大学, 大学院医学系研究科寄附講座（医）先端循環器治療学寄附講座, 寄附講座准教授
2009年9月 - 2015年10月

名古屋大学, 大学院医学系研究科附属医学教育研究支援センター, 特任講師
2007年4月 - 2009年8月

名古屋大学, 大学院医学系研究科分子総合医学専攻, 特任助教
2006年9月 - 2007年3月

名古屋大学, 大学院医学系研究科分子総合医学専攻, 助手

論文

C1q/Tumor Necrosis Factor-Related Protein 9 Protects against Acute Myocardial Injury through an Adiponectin Receptor I-AMPK-Dependent Mechanism.

Kambara T, Shibata R, Ohashi K, Matsuo K, Hiramatsu-Ito M, Enomoto T, Yuasa D, Ito M, Hayakawa S, Ogawa H …

Molecular and cellular biology 35(12) 2173-2185 2015年6月査読有り
Adipose-derived protein omentin prevents neointimal formation after arterial injury.

Uemura Y, Shibata R, Kanemura N, Ohashi K, Kambara T, Hiramatsu-Ito M, Enomoto T, Yuasa D, Joki Y, Matsuo K …

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 29(1) 141-151 2015年1月査読有り
Omentin prevents myocardial ischemic injury through AMP-activated protein kinase- and Akt-dependent mechanisms.

Kataoka Y, Shibata R, Ohashi K, Kambara T, Enomoto T, Uemura Y, Ogura Y, Yuasa D, Matsuo K, Nagata T …

Journal of the American College of Cardiology 63(24) 2722-2733 2014年6月査読有り
Therapeutic reendothelialization by induced pluripotent stem cells after vascular injury--brief report.

Yamamoto T, Shibata R, Ishii M, Kanemura N, Kito T, Suzuki H, Miyake H, Maeda K, Tanigawa T, Ouchi N …

Arteriosclerosis, thrombosis, and vascular biology 33(9) 2218-2221 2013年9月査読有り
iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis

Tetsutaro Kito, Rei Shibata, Masakazu Ishii, Hirohiko Suzuki, Tatsuhito Himeno, Yoshiyuki Kataoka, Yumiko Yamamura, Takashi Yamamoto, Naomi Nishio, Sachiko Ito …

SCIENTIFIC REPORTS 3 2013年3月査読有り
Adipose-derived factor CTRP9 attenuates vascular smooth muscle cell proliferation and neointimal formation.

Uemura Y, Shibata R, Ohashi K, Enomoto T, Kambara T, Yamamoto T, Ogura Y, Yuasa D, Joki Y, Matsuo K …

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 27(1) 25-33 2013年1月査読有り
Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity.

Ouchi N, Higuchi A, Ohashi K, Oshima Y, Gokce N, Shibata R, Akasaki Y, Shimono A, Walsh K

Science (New York, N.Y.) 329(5990) 454-457 2010年7月査読有り
Impact of a single intracoronary administration of adiponectin on myocardial ischemia/reperfusion injury in a pig model.

Kondo K, Shibata R, Unno K, Shimano M, Ishii M, Kito T, Shintani S, Walsh K, Ouchi N, Murohara T

Circulation. Cardiovascular interventions 3(2) 166-173 2010年4月査読有り
Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis.

Ackah E, Yu J, Zoellner S, Iwakiri Y, Skurk C, Shibata R, Ouchi N, Easton RM, Galasso G, Birnbaum MJ …

The Journal of clinical investigation 115(8) 2119-2127 2005年8月査読有り
Adiponectin-mediated modulation of hypertrophic signals in the heart

R Shibata, N Ouchi, M Ito, S Kihara, Shiojima, I, DR Pimentel, M Kumada, K Sato, S Schiekofer, K Ohashi …

NATURE MEDICINE 10(12) 1384-1389 2004年12月査読有り

MISC

Myonectin Is an Exercise-Induced Myokine That Protects the Heart From Ischemia-Reperfusion Injury.

Naoya Otaka, Rei Shibata, Koji Ohashi, Yusuke Uemura, Takahiro Kambara, Takashi Enomoto, Hayato Ogawa, Masanori Ito, Hiroshi Kawanishi, Sonomi Maruyama …

Circulation research 123(12) 1326-1338 2018年12月7日
C1q/TNF-related protein 9 protects against acute myocardial injury through an AdipoR1-AMPK dependent mechanism.

Kambara T, Shibata R, Ohashi K, Matsuo K, Hiramatsu-Ito M, Enomoto T, Yuasa D, Ito M, Hayakawa S, Ogawa H …

Mol. Cell. Biol. 35 2173-2185 2015年査読有り
Implantation of adipose-derived regenerative cells enhances ischemia-induced angiogenesis

Kazuhisa Kondo, Satoshi Shintani, Rei Shibata, Hisashi Murakami, Ryuichiro Murakami, Masayasu Imaizumi, Yasuo Kitagawa, Toyoaki Murohara

Arteriosclerosis, Thrombosis, and Vascular Biology 29(1) 61-66 2009年査読有り
Pioglitazone attenuates cardiac hypertrophy in rats with salt-sensitive hypertension: role of activation of AMP-activated protein kinase and inhibition of Akt.

Kato MF, Shibata R, Obata K, Miyachi M, Yazawa H, Tsuboi K, Yamada T, Nishizawa T, Noda A, Cheng XW …

J Hypertens. 26(8) 1669-1676 2008年査読有り
Usefulness of adiponectin to predict myocardial salvage following successful reperfusion in patients with acute myocardial infarction.

Shibata R, Numaguchi Y, Matsushita K, Sone T, Kubota R, Ohashi T, Ishii M, Kihara S, Walsh K, Ouchi N …

Am J Cardiol. 15(101) 2008年査読有り
Adiponectin promotes endothelial progenitor cell number and function.

Shibata R, Skurk C, Ouchi N, Galasso G, Kondo K, Ohashi T, Shimano M, Kihara S, Murohara T, Walsh K

FEBS Lett. 14(582) 2008年査読有り
Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase-dependent mechanisms

Masaki Nishimura, Yasuhiro Izumiya, Akiko Higuchi, Rei Shibata, Jianhua Qiu, Chiho Kudo, Hwa Kyoung Shin, Michael A. Moskowitz, Noriyuki Ouchi

CIRCULATION 117(2) 216-223 2008年1月査読有り
Caloric restriction stimulates revascularization in response to ischemia via adiponectin-mediated activation of eNOS.

Kondo M, Shibata R, Miura R, Shimano M, Kondo K, Li P, Ohashi T, Kihara S, Maeda N, Walsh K …

Journal of Biological Chemistry in press 2008年査読有り
Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies

Yukihiro Takemura, Noriyuki Ouchi, Rei Shibata, Tamar Aprahamian, Michael T. Kirber, Ross S. Summer, Shinji Kihara, Kenneth Walsh

JOURNAL OF CLINICAL INVESTIGATION 117(2) 375-386 2007年2月査読有り
Adiponectin protects against the development of systolic dysfunction following myocardial infarction.

Shibata R, Izumiya Y, Sato K, Papanicolaou K, Kihara S, Colucci WS, Sam F, Ouchi N, Walsh K

Journal of Molecular and Cellular Cardiology 42(6) 1065-74 2007年査読有り
Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment.

Shibata R, Sato K, Kumada M, Izumiya Y, Sonoda M, Kihara S, Ouchi N, Walsh K

Cardiovascular Research 1(74(3)) 471-9 2007年査読有り
Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction

G Galasso, S Schiekofer, K Sato, R Shibata, DE Handy, N Ouchi, JA Leopold, J Loscalzo, K Walsh

CIRCULATION RESEARCH 98(2) 254-261 2006年2月査読有り
Adiponectin replenishment ameliorates obesity-related hypertension

Ohashi K, Kihara S, Ouchi N, Shibata R, Walsh K, Funahashi T, Shimomura I

Hypertention 47(6) 1108-16 2006年査読有り
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2 dependent mechanisms

R Shibata, K Sato, DR Pimentel, Y Takemura, S Kihara, K Ohashi, T Funahashi, N Ouchi, K Walsh

NATURE MEDICINE 11(10) 1096-1103 2005年10月査読有り
Akt1/protein kinase B alpha is critical for ischemic and VEGF-mediated angiogenesis

E Ackah, J Yu, S Zoellner, Y Iwakiri, C Skurk, R Shibata, N Ouchi, RM Easton, G Galasso, MJ Birnbaum …

JOURNAL OF CLINICAL INVESTIGATION 115(8) 2119-2127 2005年8月査読有り
AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle

N Ouchi, R Shibata, K Walsh

CIRCULATION RESEARCH 96(8) 838-846 2005年4月査読有り
Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of AMP-activated protein kinase signaling

R Shibata, N Ouchi, S Kihara, K Sato, T Funahashi, K Walsh

JOURNAL OF BIOLOGICAL CHEMISTRY 279(27) 28670-28674 2004年7月査読有り
Adiponectin-mediated modulation of hypertrophic signals in the heart.

Shibata R, Ouchi N, Ito M, Kihara S, Shiojima I, Pimentel DR, Kumada M, Sato K, Schiekofer S, Ohashi K …

Nature Medicine 10 1384-1389 2004年査読有り
Apoptosis induced by inhibition of cyclic AMP response element-binding protein in vascular smooth muscle cells

T Tokunou, R Shibata, H Kai, T Ichiki, T Morisaki, K Fukuyama, H Ono, N Iino, S Masuda, H Shimokawa …

CIRCULATION 108(10) 1246-1252 2003年9月査読有り
Role of Rho-associated kinase in neointima formation after vascular injury

R Shibata, H Kai, Y Seki, S Kato, M Morimatsu, K Kaibuchi, T Imaizumi

CIRCULATION 103(2) 284-289 2001年1月査読有り

書籍等出版物

痩せりゃいい、ってもんじゃない!―脂肪の科学

森永卓郎, 柴田玲 (担当:共著)

文春新書 2008年6月

共同研究・競争的資金等の研究課題

脂肪細胞由来因子の心血管リモデリング制御機構の解明と治療への応用

科学研究費助成事業若手研究（Ａ），課題番号：19689016 2007年

柴田玲