KITATANI Kazuyuki Last updated: Dec 22, 2019 at 13:59
Academic & Professional Experience
Apr 2018
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Today
Associate Professor, Faculty of Pharmaceutical Sciences, Setsunan University
Apr 2017
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Mar 2018
Senior Assistant Professor, Graduate School of Medicine, Tohoku University
Apr 2012
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Mar 2017
Assistant Professor, Tohoku Medical Megabank Organization, Tohoku University
Dec 2008
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Mar 2012
Assistant Professor, Department of Clinical Laboratory/Hematology, Tottori University Hospital
Jul 2007
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Nov 2008
Instructor (Faculty Appointment), Department of Biochemistry and Molecular Biology, Medical University of South Carolina
Oct 2002
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Jun 2007
Post doctral fellow, Dr. Yusuf A. Hannun Laboratory, Department of Biochemistry and Molecular Biology, Medical University of South Carolina
2007
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2007
Visiting Scientis, Cincinnati Children’s Hospital, Division of Human Genetics
Awards & Honors
2016
Outstanding Contribution in Reviewing, European Journal of Surgical Oncology
Apr 2012
Young Investigator Award, Gaucher Generation Program (Sanofi)
Nov 2006
Travel Award, 41th Annual Southeaster Regional Lipid Conference
Nov 2004
Postdoctral Award, 39th Annual Southeaster Regional Lipid Conference
Published Papers
Study Profile of The Tohoku Medical Megabank Community-Based Cohort Study
Hozawa A. et al.,
Journal of Epidemiology Dec 2019 [Refereed]
Adoptive transfer of type 1 regulatory T cells suppressed the development of airway hyperresponsiveness in ovalbumin-induced airway inflammation model mice
Masaya Matsuda, Kana Doi, Tatsuya Tsutsumi, Miki Inaba, Junpei Hamaguchi, Tetsuya Terada, Ryo Kawata, Kazuyuki Kitatani, Takeshi Nabe
Journal of Pharmacological Sciences 141(4) 139-145 Oct 2019 [Refereed]
Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): Rationale, Progress and Perspective.
Kuriyama S. et al.
International Journal of Epidemiology 25 Aug 2019 [Refereed]
La-Related Protein 4 as a Suppressor for Motility of Ovarian Cancer Cells.
Egiz M., Usui T., Ishibashi M, Zhang X, Toyoshima M, Shigeta S, Usui T, Kitatani K, Yaegashi N.
247 59-67 Jan 2019 [Refereed]
Ishibashi M, Toyoshima M, Zhang X, Hasegawa-Minato J, Shigeta S, Usui T, Kemp CJ, Grandori C, Kitatani K, Yaegashi N.
Scientific Reports Dec 2018 [Refereed]
Zhang X, Kitatani K, Toyoshima M, Ishibashi M, Usui T, Minato J, Egiz M, Shigeta S, Fox T, Deering T, Kester M, Yaegashi N.
Molecular Cancer Therapeutics 17(1) 50-59 2018 [Refereed]
Hasegawa-Minato J, Toyoshima M, Ishibashi M, Zhang X, Shigeta S, Grandori C, Kitatani K, Yaegashi N.
Oncotarget 9(3) 3483-3496 2018 [Refereed]
M Wada, D Canals, M Adada, N Coant, M F Salama, K L Helke, J S Arthur, K R Shroyer, K Kitatani, L M Obeid, Y A Hannun
Oncogene Nov 2017 [Refereed]
The Tohoku Medical Megabank Project: Design and Mission
Kuriyama S. et al.
J. Epidemiol 26 493-511 2016 [Refereed]
Kitatani K, Usui T, Sriraman S.K, Toyoshima M, Ishibashi M, Shigeta S, Nagase S, Sakamoto M, Ogiso H, Okazaki T, Hannun Y.A, Torchilin V.P, Yaegashi N.
Oncogene 35(21) 2801-2812 2016 [Refereed]
Mizuno S, Ogishima S, Kitatani K, Kikuchi M, Tanaka H, Yaegashi N, Nakaya J.
PLoS ONE 11(2) 2016 [Refereed]
Shigeta S, Toyoshima M, Kitatani K, Ishibashi M, Usui T, Yaegashi N.
Oncogene 35(27) 3577-3586 2016 [Refereed]
Kitatani K, Wada M, Perry D, Usui T, Sun Y, Obeid L.M, Yaegashi N, Grabowski G.A, Hannun Y.A.
PLoS ONE 10(8) 2015 [Refereed]
Yazama H, Kitatani K, Fujiwara K, Kato M, Hashimoto-Nishimura M, Kawamoto K, Hasegawa K, Kitano H, Bielawska A, Bielawski J, Okazaki T.
International Journal of Clinical Oncology 20(3) 438-446 2015 [Refereed]
Mashiko S, Kitatani K, Toyoshima M, Ichimura A, Dan T, Usui T, Ishibashi M, Shigeta S, Nagase S, Miyata T, Yaegashi N.
Cancer Biology and Therapy 16(2) 253-260 2015 [Refereed]
Taniguchi M, Ogiso H, Takeuchi T, Kitatani K, Umehara H, Okazaki T.
Cell Death and Disease 6(4) 2015 [Refereed]
Kitatani K, Taniguchi M, Okazaki T.
Molecules and Cells 38(6) 482-495 2015 [Refereed]
Perry D.M, Newcomb B, Adada M, Wu B.X, Roddy P, Kitatani K, Siskind L, Obeid L.M, Hannun Y.A.
Journal of Biological Chemistry 289(32) 22401-22412 2014 [Refereed]
Tsounapi P, Saito M, Kitatani K, Dimitriadis F, Ohmasa F, Shimizu S, Kinoshita Y, Takenaka A, Satoh K.
European Journal of Pharmacology 691(1-3) 182-189 2012 [Refereed]
Perry D.M, Kitatani K, Roddy P, El-Osta M, Hannun Y.A.
Journal of Lipid Research 53(8) 1513-1521 2012 [Refereed]
Ohmasa F, Saito M, Oiwa H, Tsounapi P, Shomori K, Kitatani K, Dimitriadis F, Kinoshita Y, Satoh K.
BJU International 110(6B) 2012 [Refereed]
Taniguchi M, Kitatani K, Kondo T, Hashimoto-Nishimura M, Asano S, Hayashi A, Mitsutake S, Igarashi Y, Umehara H, Takeya H, Kigawa J, Okazaki T.
Journal of Biological Chemistry 287(47) 39898-39910 2012 [Refereed]
Asano S, Kitatani K, Taniguchi M, Hashimoto M, Zama K, Mitsutake S, Igarashi Y, Takeya H, Kigawa J, Hayashi A, Umehara H, Okazaki T.
Molecular and Cellular Biology 32(16) 3242-3252 2012 [Refereed]
Tsounapi P, Saito M, Dimitriadis F, Kitatani K, Kinoshita Y, Shomori K, Takenaka A, Satoh K.
Life Sciences 90(17-18) 649-656 2012 [Refereed]
Fujiwara K, Kitatani K, Fukushima K, Yazama H, Umehara H, Kikuchi M, Igarashi Y, Kitano H, Okazaki T.
International Journal of Clinical Oncology 16(2) 133-140 2011 [Refereed]
Sun Y, Ran H, Liou B, Quinn B, Zamzow M, Zhang W, Bielawski J, Kitatani K, Setchell K.D.R, Hannun Y.A, Grabowski G.A.
PLoS ONE 6(4) 2011 [Refereed]
El-Shewy H.M, Abdel-Samie S.A, al Qalam A.M, Lee M.-H, Kitatani K, Anelli V, Jaffa A.A, Obeid L.M, Luttrell L.M.
Molecular Endocrinology 25(12) 2144-2156 2011 [Refereed]
Jenkins R.W, Clarke C.J, Canals D, Snider A.J, Gault C.R, Heffernan-Stroud L, Wu B.X, Simbari F, Roddy P, Kitatani K, Obeid L.M, Hannun Y.A.
Journal of Biological Chemistry 286(15) 13292-13303 2011 [Refereed]
Lafont E, Kitatani K, Okazaki T, S{é}gui B.
Recent Patents on Anti-Cancer Drug Discovery 6(3) 324-333 2011 [Refereed]
Mullen T.D, Spassieva S, Jenkins R.W, Kitatani K, Bielawski J, Hannun Y.A, Obeid L.M.
Journal of Lipid Research 52(1) 68-77 2011 [Refereed]
Shakor A.B.A, Taniguchi M, Kitatani K, Hashimoto M, Asano S, Hayashi A, Nomura K, Bielawski J, Bielawska A, Watanabe K, Kobayashi T, Igarashi Y, Umehara H, Takeya H, Okazaki T.
Journal of Biological Chemistry 286(41) 36053-36062 2011 [Refereed]
Kitatani K, Asano S, Hashimoto M, Taniguchi M, Okazaki T.
Seikagaku 83(6) 495-505 2011 [Refereed]
Sun Y, Liou B, Ran H, Skelton M.R, Williams M.T, Vorhees C.V, Kitatani K, Hannun Y.A, Witte D.P, Xu Y.-H, Grabowski G.A.
Human Molecular Genetics 19(6) 1088-1097 2010 [Refereed]
Jenkins R.W, Canals D, Idkowiak-Baldys J, Simbari F, Roddy P, Perry D.M, Kitatani K, Luberto C, Hannun Y.A.
Journal of Biological Chemistry 285(46) 35706-35718 2010 [Refereed]
Kitatani K, Luberto C.
Advances in experimental medicine and biology 688 276-285 2010 [Refereed]
Kitatani K, Sheldon K, Anelli V, Jenkins R.W, Sun Y, Grabowski G.A, Obeid L.M, Hannun Y.A.
Journal of Biological Chemistry 284(19) 12979-12988 2009 [Refereed]
Kitatani K, Sheldon K, Rajagopalan V, Anelli V, Jenkins R.W, Sun Y, Grabowski G.A, Obeid L.M, Hannun Y.A.
Journal of Biological Chemistry 284(19) 12972-12978 2009 [Refereed]
Sun Y, Ran H, Zamzow M, Kitatani K, Skelton M.R, Williams M.T, Vorhees C.V, Witte D.P, Hannun Y.A, Grabowski G.A.
Human Molecular Genetics 19(4) 634-647 2009 [Refereed]
Sundaram K, Mani S.K, Kitatani K, Wu K, Pestell R.G, Reddy S.V.
Journal of Cellular Biochemistry 103(6) 1747-1759 2008 [Refereed]
The sphingolipid salvage pathway in ceramide metabolism and signaling.
Kitatani K., Idkowiak-Baldys J., Hannun Y.A.
Cell. Signal. 20 1010-1018 2008 [Invited]
Kitatani K, Idkowiak-Baldys J, Hannun Y.A.
Journal of Biological Chemistry 282(28) 20647-20656 2007 [Refereed]
Idkowiak-Baldys J, Becker K.P, Kitatani K, Hannun Y.A.
Journal of Biological Chemistry 281(31) 22321-22331 2006 [Refereed]
Taha T.A, Kitatani K, El-Alwani M, Bielawski J, Hannun Y.A, Obeid L.M.
FASEB Journal 20(3) 482-484 2006 [Refereed]
Kitatani K, Idkowiak-Baldys J, Bielawski J, Taha T.A, Jenkins R.W, Senkal C.E, Ogretmen B, Obeid L.M, Hannun Y.A.
Journal of Biological Chemistry 281(48) 36793-36802 2006 [Refereed]
Becker K.P, Kitatani K, Idkowiak-Baldys J, Bielawski J, Hannun Y.A.
Journal of Biological Chemistry 280(4) 2606-2612 2005 [Refereed]
Pettus B.J, Kitatani K, Chalfant C.E, Taha T.A, Kawamori T, Bielawski J, Obeid L.M, Hannun Y.A.
Molecular Pharmacology 68(2) 330-335 2005 [Refereed]
Taha T.A, Kitatani K, Bielawski J, Cho W, Hannun Y.A, Obeid L.M.
Journal of Biological Chemistry 280(17) 17196-17202 2005 [Refereed]
Kitatani K, Akiba S, Sato T.
Cellular Signalling 16(8) 967-974 2004 [Refereed]
Kitatani K, Nemoto M, Akiba S, Sato T.
Cellular Signalling 14(8) 695-701 2002 [Refereed]
Kitatani K, Akiba S, Hayama M, Sato T.
Archives of Biochemistry and Biophysics 395(2) 208-214 2001 [Refereed]
Misc
Kitatani K, Iwabuchi K, Snider A, Riboni L.
Mediators of Inflammation 2016 2016 [Invited]
酒粕に含まれるスフィンゴ脂質の検出・半定量的評価とその由来の解析
平田みよ，浦野義崇，稲葉繁樹,北谷和之,岡崎俊朗，北垣浩志
J. Brew. Soc. Japan 106 848-853 2012 [Refereed]
C型慢性肝炎の治療薬開発を通してみた国内外の臨床試験検索サイトの活用方法の模索
牧江俊雄，黒田祥平,中村剛，今井優樹，森永紀，北谷和之
医薬品医療機器レギュラトリーサイエンス 43 446-451 2012 [Refereed]
スフィンゴ脂質を利用した機能性リポソーム
北谷和之
生物工学会誌 88 678-678 2010 [Invited]
Regulation of ceramide by sphingomyelin synthase
北谷和之,橋本真由美,杉本優子,谷口真,岡崎俊朗
Cells 41 8-11 2009 [Invited]
セラミドと悪性腫瘍
北谷和之,岡崎俊朗
The Lipids 20 289-290 2009 [Invited]
セラミドを中心としたスフィンゴ脂質代謝
北谷和之，浅野智志，橋本真由美,谷口真、岡崎俊朗
生化学 83 495-505 2011 [Invited]
Kitatani K, Cowart L.A, Hannun Y.A.
Sphingolipid Biology 153-165 2006 [Refereed][Invited]
Books etc
Generation of signaling molecules by de novo sphingolipid synthesis
Kitatani K., Cowart L. A., and Hannun Y. A. (Part:Joint Work, Sphingolipid Biology)
Springer 2006
セラミドの細胞内機能概論：スフィンゴミエリン合成酵素ファミリー
北谷和之,岡崎俊朗 (Part:Joint Work)
2011
Conference Activities & Talks
Ceramide synthase 2-ceramide axis limits metastatic potential of ovarian cancer
KITATANI Kazuyuki
2 May 2017
Ceramide limits phosphatidylinositol-3-kinase-controlled cell motility in ovarian cancer: potential of ceramide as a tumor metastasis suppressor
Kitatani K, Usui T, Sriraman SK, Ogiso H, Toyoshima M, Ishibashi M, Shigeta S, Nagase S, Okazaki T, Hannun YA, Torchilin, VP, Yaegashi N
iCC/SLC 6 May 2015
Ceramide limits phosphatidylinositol3-kinase C2β-controlled cell motility in ovarian cancer: potential of ceramide liposomes as antimetastatic reagents.
KITATANI Kazuyuki
29 Mar 2015
Identification of Ceramide as an Inhibitory Lipid for Phosphatidylinositol-3-Kinase-Controlled Cell Motility in Ovarian Cancer: Potential of Ceramide as an Antimetastatic Reagent
MasafumiToyoshima、ShravanK.Sriraman、MasumiIshibashi、ShogoShigeta、SatsukiMashiko、SatoruNagase、MasahiroSakamoto、VladimirP.Torchilin、YusufA.Hannun、NobuoYaegashi
7th International Ceramide Conference 20 Oct 2013
セラミドによる細胞移動性の調節：卵巣がん転移をおさえる創薬に向けて
豊島将文、増子さつき、重田昌吾、石橋ますみ、八重樫伸生
第８回スフィンゴテラピィ研究会 12 Jul 2013
卵巣がん転移を標的にした創薬：スフィンゴ脂質の利用
豊島将文、増子さつき、重田昌吾、石橋ますみ、八重樫伸生
第１２回日本婦人科分子標的研究会 5 Jul 2013
セラミドによる細胞移動運動の調節
豊島将文、増子さつき、重田昌吾、石橋ますみ、八重樫伸生
第５５回日本脂質生化学会 6 Jun 2013
Research Grants & Projects
Roles for ceramide in ovarian cancer
JSPS: kakenhi
Project Year: Apr 2016 - Mar 2019 Investigator(s): KITATANI Kazuyuki
Identification of acid β-glucosidase as a tumor suppressor gene
Mizutani Foundation for Glycoscience:
Project Year: Apr 2017 - Sep 2018 Investigator(s): KITATANI Kazuyuki
Cancer biology of ceramide synthases and establishment of cancer therapeutics
Takeda Science Foundation:
Project Year: Apr 2017 - Mar 2018 Investigator(s): KITATANI Kazuyuki
Ceramide-based therapy for ovarian cancer metastasis
JSPS: kakenhi
Project Year: Apr 2014 - Mar 2015 Investigator(s): KITATANI Kazuyuki
p38δ is a novel target for anti-inflammation therapy of Gaucher's disease.
Gaucher Generation Grant: New Investigator Award
Project Year: Apr 2012 - Mar 2015 Investigator(s): Kazuyuki Kitatani
Regulation of inflammation by sphingolipid salvage
Grant-in-Aid for Scientific Research
Project Year: Apr 2011 - Mar 2012 Investigator(s): Kazuyuki Kitatani
Role of ceramide in molecular cell biology
The Sumitomo Foundation:
Project Year: Apr 2010 - Mar 2011 Investigator(s): KITATANI Kazuyuki
Regulation of sphingolipid signal by acid-beta-glucosidase
JSPS: kakenhi
Project Year: Apr 2009 - Mar 2010 Investigator(s): KITATANI Kazuyuki
Social Contribution
Multidisciplinary Approach Forum MAF 2014
[Presenter, Planner] 20 Sep 2014 - 21 Sep 2014
