2011年3月
Diarylprolinol in the Direct Asymmetric Aldol Reaction of Trifluoromethylacetaldehyde Ethyl Hemiacetal with Aldehyde
SYNLETT
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- 巻
- 2011
- 号
- 4
- 開始ページ
- 485
- 終了ページ
- 488
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1055/s-0030-1259543
- 出版者・発行元
- GEORG THIEME VERLAG KG
Asymmetric direct aldol reaction of trifluoromethylacetaldehyde with aldehyde using diarylprolinol as a catalyst, to afford a synthetically useful beta-trifluoromethyl-beta-hydroxy aldehyde with excellent enantioselectivity, was developed. Commercially available trifluoromethylacetaldehyde ethyl hemiacetal was used directly as a precursor of trifluoromethylacetaldehyde without acid pyrolysis or distillation prior to use.
- リンク情報
- ID情報
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- DOI : 10.1055/s-0030-1259543
- ISSN : 0936-5214
- Web of Science ID : WOS:000287575400009