家村俊一郎 (Shun'ichiro Iemura) - マイポータル

基本情報

所属: 福島県立医科大学ふくしま国際医療科学センター医療-産業TRセンター教授

学位: 博士（理学）(総合研究大学院大学)
Doctor of Science(The Graduate University for Advanced Studies)

J-GLOBAL ID: 201201034255243379
researchmap会員ID: 7000003735

研究キーワード

研究分野

ナノテク・材料 / 分析化学 / 分析化学

論文

109

NUDT21 Links Mitochondrial IPS-1 to RLR-Containing Stress Granules and Activates Host Antiviral Defense.

Aoyama-Ishiwatari S, Okazaki T, Iemura SI, Natsume T, Okada Y, Gotoh Y

Journal of immunology (Baltimore, Md. : 1950) 206(1) 154-163 2021年1月1日査読有り
Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis.

Hideo Negishi, Nobuyasu Endo, Yuki Nakajima, Tatsuaki Nishiyama, Yuichiro Tabunoki, Junko Nishio, Ryuji Koshiba, Atsushi Matsuda, Kosuke Matsuki, Tomohisa Okamura …

Proceedings of the National Academy of Sciences of the United States of America 116(47) 23653-23661 2019年11月19日査読有り
Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B.

Tomohisa Hatta, Shun-Ichiro Iemura, Tomokazu Ohishi, Hiroshi Nakayama, Hiroyuki Seimiya, Takao Yasuda, Katsumi Iizuka, Mitsunori Fukuda, Jun Takeda, Tohru Natsume …

Scientific reports 8(1) 16756-16756 2018年11月13日
MERIT40-dependent recruitment of tankyrase to damaged DNA and its implication for cell sensitivity to DNA-damaging anticancer drugs.

Okamoto K, Ohishi T, Kuroiwa M, Iemura SI, Natsume T, Seimiya H

Oncotarget 9(88) 35844-35855 2018年11月9日
Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma.

Kim Y, Shiba-Ishii A, Nakagawa T, Iemura SI, Natsume T, Nakano N, Matsuoka R, Sakashita S, Lee S, Kawaguchi A …

Oncogene 37(40) 5387-5402 2018年10月
Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells

Tatsuyuki Matsudaira, Kojiro Mukai, Taishin Noguchi, Junya Hasegawa, Tomohisa Hatta, Shun-ichiro Iemura, Tohru Natsume, Norio Miyamura, Hiroshi Nishina, Jun Nakayama …

NATURE COMMUNICATIONS 8(1) 1246 2017年11月
Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation

Tsutomu Fujimori, Ryoji Suno, Shun-Ichiro Iemura, Tohru Natsume, Ikuo Wada, Nobuko Hosokawa

GENES TO CELLS 22(8) 684-698 2017年8月
Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion

Tomokazu Ohishi, Haruka Yoshida, Masamichi Katori, Toshiro Migita, Yukiko Muramatsu, Mao Miyake, Yuichi Ishikawa, Akio Saiura, Shun-Ichiro Iemura, Tohru Natsume …

CANCER RESEARCH 77(9) 2328-2338 2017年5月
TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation.

Nakano N, Tsuchiya Y, Kako K, Umezaki K, Sano K, Ikeno S, Otsuka E, Shigeta M, Nakagawa A, Sakata N …

The Journal of biological chemistry 292(10) 4099-4112 2017年3月
WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway

Toshiyasu Goto, Junhei Matsuzawa, Shun-ichiro Iemura, Tohru Natsume, Hiroshi Shibuya

FEBS LETTERS 590(9) 1291-1303 2016年5月査読有り
Distinct types of protease systems are involved in homeostasis regulation of mitochondrial morphology via balanced fusion and fission.

Shotaro Saita, Takaya Ishihara, Maki Maeda, Shun-Ichiro Iemura, Tohru Natsume, Katsuyoshi Mihara, Naotada Ishihara

Genes to cells : devoted to molecular & cellular mechanisms 21(5) 408-24 2016年5月査読有り
Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi

Takashi Fukuzono, Strahil Iv. Pastuhov, Okinobu Fukushima, Chun Li, Ayuna Hattori, Shun-ichiro Iemura, Tohru Natsume, Hiroshi Shibuya, Hiroshi Hanafusa, Kunihiro Matsumoto …

GENES TO CELLS 21(4) 311-324 2016年4月査読有り
TBL2 Associates With ATF4 mRNA Via Its WD40 Domain and Regulates Its Translation During ER Stress

Yoshinori Tsukumo, Satomi Tsukahara, Aki Furuno, Shun-ichiro Iemura, Tohru Natsume, Akihiro Tomida

JOURNAL OF CELLULAR BIOCHEMISTRY 117(2) 500-509 2016年2月査読有り
The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1

Akihiro Ito, Tadahiro Shimazu, Satoko Maeda, Asad Ali Shah, Tatsuhiko Tsunoda, Shun-ichiro Iemura, Toru Natsume, Takafumi Suzuki, Hozumi Motohashi, Masayuki Yamamoto …

SCIENCE SIGNALING 8(404) 2015年11月査読有り
CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2

Yu Kigoshi, Tomomi Fukuda, Tomoyuki Endo, Nami Hayasaka, Shun-ichiro Iemura, Toru Natsume, Fuminori Tsuruta, Tomoki Chiba

SCIENTIFIC REPORTS 5 2015年8月査読有り
The endoplasmic reticulum-localized protein TBL2 interacts with the 60S ribosomal subunit

Yoshinori Tsukumo, Satomi Tsukahara, Aki Furuno, Shun-ichiro Iemura, Tohru Natsume, Akihiro Tomida

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 462(4) 383-388 2015年7月査読有り
Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity

Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Hiroyasu Kamei, Fumihiko Hakuno, Jing Luan, Cunming Duan, Yasushi Saeki, Keiji Tanaka, Shun-Ichiro Iemura …

NATURE COMMUNICATIONS 6 2015年4月査読有り
TBL2 Is a Novel PERK-Binding Protein that Modulates Stress-Signaling and Cell Survival during Endoplasmic Reticulum Stress

Yoshinori Tsukumo, Satomi Tsukahara, Aki Furuno, Shun-ichiro Iemura, Toru Natsume, Akihiro Tomida

PLOS ONE 9(11) 2014年11月査読有り
Structure-activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201

Nobuhiko Hayakawa, Masatsugu Noguchi, Sen Takeshita, Agung Eviryanti, Yukie Seki, Hikaru Nishio, Ryohei Yokoyama, Misato Noguchi, Manami Shuto, Yoichiro Shima …

BIOORGANIC & MEDICINAL CHEMISTRY 22(11) 3021-3029 2014年6月査読有り
ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway

Shungo Adachi, Masae Homoto, Rikou Tanaka, Yusaku Hioki, Hiroshi Murakami, Hiroaki Suga, Masaki Matsumoto, Keiichi I. Nakayama, Tomohisa Hatta, Shun-ichiro Iemura …

NUCLEIC ACIDS RESEARCH 42(15) 10037-10049 2014年査読有り

もっとみる

MISC

NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)

Misato Yamada, Junji Ohnishi, Bisei Ohkawara, Shunichiro Iemura, Kiyotoshi Satoh, Junko Hyodo-Miura, Kaoru Kawachi, Tohru Natsume, Hiroshi Shibuya

JOURNAL OF BIOLOGICAL CHEMISTRY 281(30) 20749-20760 2006年7月査読有り
XGAP, an ArfGAP, is required for polarized localization of PAR proteins and cell polarity in Xenopus gastrulation

Junko Hyodo-Miura, Takamasa S. Yamamoto, Akiko C. Hyodo, Shun-Ichiro Lemura, Morioh Kusakabe, Eisuke Nishida, Tohru Natsume, Naoto Ueno

DEVELOPMENTAL CELL 11(1) 69-79 2006年7月査読有り
Shugoshin collaborates with protein phosphatase 2A to protect cohesin

TS Kitajima, T Sakuno, K Ishiguro, S Iemura, T Natsume, SA Kawashima, Y Watanabe

NATURE 441(7089) 46-52 2006年5月査読有り
Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases

K Terasawa, K Yoshimatsu, S Iemura, T Natsume, K Tanaka, Y Minami

MOLECULAR AND CELLULAR BIOLOGY 26(9) 3378-3389 2006年5月査読有り
A novel ubiquitin-binding protein ZNF216 functioning in muscle atrophy

A Hishiya, S Iemura, T Natsume, S Takayama, K Ikeda, K Watanabe

EMBO JOURNAL 25(3) 554-564 2006年2月査読有り
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1

T Moriguchi, S Urushiyama, N Hisamoto, SI Iemura, S Uchida, T Natsume, K Matsumoto, H Shibuya

JOURNAL OF BIOLOGICAL CHEMISTRY 280(52) 42685-42693 2005年12月
A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes

Y Hirano, KB Hendil, H Yashiroda, S Iemura, R Nagane, Y Hioki, T Natsume, K Tanaka, S Murata

NATURE 437(7063) 1381-1385 2005年10月査読有り
DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex

N Matsuda, K Azuma, M Saijo, SI Iemura, Y Hioki, T Natsume, T Chiba, K Tanaka, K Tanaka

DNA REPAIR 4(5) 537-545 2005年5月査読有り
STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFβ-activated kinase 1 for STAT3 Ser-727 phosphorylation

KOJIMA Hirotada, SASAKI Takanori, ISHITANI Tohru, IEMURA Shun‐ichiro, ZHAO Hong, KANEKO Shuhei, KUNIMOTO Hiroyuki, NATSUME Tohru, MATSUMOTO Kunihiro

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102(12) 4524-4529 2005年3月
An RNA-interacting protein, SYNCRIP (heterogeneous nuclear ribonuclear protein Q1/NSAP1) is a component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendrites

H Bannai, K Fukatsu, A Mizutani, T Natsume, S Iemura, T Ikegami, T Inouie, K Mikoshiba

JOURNAL OF BIOLOGICAL CHEMISTRY 279(51) 53427-53434 2004年12月
Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders

S Ishigaki, N Hishikawa, J Niwa, S Iemura, T Natsume, S Hori, A Kakizuka, K Tanaka, G Sobue

JOURNAL OF BIOLOGICAL CHEMISTRY 279(49) 51376-51385 2004年12月
A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier

M Komatsu, T Chiba, K Tatsumi, S Iemura, Tanida, I, N Okazaki, T Ueno, E Kominami, T Natsume, K Tanaka

EMBO JOURNAL 23(9) 1977-1986 2004年5月査読有り
Skp2-mediated degradation of p27 regulates progression into mitosis

K Nakayama, H Nagahama, YA Minamishima, S Miyake, N Ishida, S Hatakeyama, M Kitagawa, S Iemura, T Natsume, KI Nakayama

DEVELOPMENTAL CELL 6(5) 661-672 2004年5月

書籍等出版物

Protein Interaction

(担当:共著)

Intech 2012年3月16日 (ISBN: 9789535102441)
Real-time analysis of biomolecular interactions: applications of BIACORE

(担当:共著)

Springer-Verlag 2000年8月 (ISBN: 9784431702894)
生体物質相互作用のリアルタイム解析実験法

永田和宏, 半田宏 (担当:共著, 範囲:初期発生におけるタンパク質間相互作用の解析ーオーガナイザー因子フォリスタチンとBMPの直接結合ー)

シュプリンガー・フェアラーク東京 1998年11月 (ISBN: 9784431707912)

講演・口頭発表等

超々高感度質量分析への挑戦

家村俊一郎

日本ヒトプロテオーム機構第8回大会・第6回日本臨床プロテオーム研究会連合大会 2010年7月27日
質量分析のための試料前処理法：プロテオミクス分野

家村俊一郎

第33回 BMSコンファレンス(BMS2006) 2006年7月3日
Molecular assembly of mammalian 20S proteasomes

Murata, S, Hirano, Y, Hendil, K.B, Iemura, S, Natsume, T, Tanaka, K

20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress 2006年6月23日
Systematic Analysis of Protein Interaction Networks Using Human Full Length cDNA

Iemura, S

20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress 2006年6月19日