論文

査読有り 筆頭著者 国際誌
2021年5月4日

Distinct spatiotemporal distribution of Hsp90 under high-heat and mild-heat stress conditions in fission yeast.

microPublication biology
  • Teruaki Takasaki
  • ,
  • Naofumi Tomimoto
  • ,
  • Takumi Ikehata
  • ,
  • Ryosuke Satoh
  • ,
  • Reiko Sugiura

2021
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.17912/micropub.biology.000388

The molecular chaperone Hsp90 is highly conserved from bacteria to mammals. In fission yeast, Hsp90 is essential in many cellular processes and its expression is known to be increased by heat stress (HS). Here, we describe the distinct spatiotemporal distribution of Hsp90 under high-heat stress (HHS: 45˚C) and mild-heat stress (MHS: 37˚C). Hsp90 is largely distributed in the cytoplasm under non-stressed conditions (27˚C). Under HHS, Hsp90 forms several cytoplasmic granules within 5 minutes, then the granules disappear within 60 minutes. Under MHS, Hsp90 forms fewer granules than under HHS within 5 minutes and strikingly the granules persist and grow in size. In addition, nuclear enrichment of Hsp90 was observed after 60 minutes under both HS conditions. Our data suggest that assembly/disassembly of Hsp90 granules is differentially regulated by temperatures.

リンク情報
DOI
https://doi.org/10.17912/micropub.biology.000388
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34036246
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140757
ID情報
  • DOI : 10.17912/micropub.biology.000388
  • PubMed ID : 34036246
  • PubMed Central 記事ID : PMC8140757

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