Chie Aoki-Utsubo

Profile Information

Affiliation: Assistant Professor, Graduate School of Health Sciences Faculty of Health Sciences, Kobe University

Degree: 修士（薬学）(静岡県立大学)
博士（薬学）(静岡県立大学)

J-GLOBAL ID: 201301002035033746
researchmap Member ID: 7000004025

Research Interests

Research Areas

Research History

Apr, 2014 - Mar, 2015

Kobe University, Graduate School of Medicine, Center for Infectious Diseases
Apr, 2010 - Feb, 2014

インドネシア大学医学部
Apr, 2007 - Mar, 2010

中国科学院微生物研究所

Education

- Mar, 2007

Doctor Course, Graduate School of Pharmaceutical Sciences, University of Shizuoka

Awards

Nov, 2014

若手研究者奨励賞, 細菌学会関西支部総会

青木千恵

Papers

Identification of an Oligostilbene, Vaticanol B, from Dryobalanops aromatica Leaves as an Antiviral Compound against Hepatitis C Virus

Chie Aoki-Utsubo, Muhammad Hanafi, Destia Tri Armanti, Hiroyuki Fuchino, Nobuo Kawahara, Sri Hartati, Aty Widyawaruyanti, Pratiwi Sudarmono, Masanori Kameoka, Hak Hotta

Biol. Pharm. Bull., 46(8) 1079-1087, Aug 1, 2023 Peer-reviewedLead authorCorresponding author
Amentoflavone inhibits hepatitis B virus infection via the suppression of preS1 binding to host cells.

Chie Aoki-Utsubo, Puguh Indrasetiawan, Kento Fukano, Masamichi Muramatsu, Nina Artanti, Muhammad Hanafi, Hak Hotta, Masanori Kameoka

Microbiology and immunology, Mar 16, 2023 Lead authorCorresponding author
Acacia mangium: A promising plant for isolating anti-hepatitis C virus agents

Tutik Sri Wahyuni, Nida S. Sukma, Adita A. Permanasari, Chie Aoki-Utsubo, Aty Widyawaruyanti, Achmad Fuad Hafid

F1000Research, 11 1452-1452, Feb 28, 2023
An in vitro study of an Artocarpus heterophyllus substance as a hepatitis C antiviral and its combination with current anti-HCV drugs

Adita Ayu Permanasari, Chie Aoki-Utsubo, Tutik Sri Wahyuni, Lidya Tumewu, Myrna Adianti, Aty Widyawaruyanti, Hak Hotta, Achmad Fuad Hafid

BMC Complementary Medicine and Therapies, 21(1), Dec, 2021
Alkaloid and benzopyran compounds of Melicope latifolia fruit exhibit anti-hepatitis C virus activities

Aty Widyawaruyanti, Mulyadi Tanjung, Adita Ayu Permanasari, Ratih Saputri, Lidya Tumewu, Myrna Adianti, Chie Aoki-Utsubo, Hak Hotta, Achmad Fuad Hafid, Tutik Sri Wahyuni

BMC Complementary Medicine and Therapies, 21(1), Dec, 2021
Antiviral activity of Indonesian Medicinal Plants against hepatitis B virus.

Wahyuni TS, Permanasari A, Widyawaruyanti A, Hotta H, Chie AU, Hafid A

12(5) 1108-1114, 2020
Smp76, a Scorpine-Like Peptide Isolated from the Venom of the Scorpion Scorpio maurus palmatus, with a Potent Antiviral Activity Against Hepatitis C Virus and Dengue Virus

Alaa M.H. El-Bitar, Moustafa Sarhan, Mohamed A. Abdel-Rahman, Veronica Quintero-Hernandez, Chie Aoki-Utsubo, Mohsen A. Moustafa, Lourival D. Possani, Hak Hotta

International Journal of Peptide Research and Therapeutics, 26(2) 811-821, Jan 1, 2019
Antiviral Activity of Cananga odorata Against Hepatitis B

Indrasetiawan P, Aoki-Utsubo C, Hanafi M, Hartati S, Wahyuni TS, Kameoka M, Hotta H, Hayashi Y

Kobe Journal of Medical Sciences, 65(2) E71-E79, 2019 Peer-reviewedCorresponding author
Antiviral Activities of Curcuma Genus against Hepatitis C Virus

Tutik Sri Wahyuni, Adita Ayu Permatasari, Tri Widiandani, Achmad Fuad, Aty Widyawaruyanti, Chie Aoki-Utsubo, Hak Hotta

NATURAL PRODUCT COMMUNICATIONS, 13(12) 1579-1582, Dec, 2018 Peer-reviewed
Potential of Indonesian Plants (Annona muricata, Garcinia latissima, and Garcinia celebica) Against Hepatitis C Virus

Apriyanto Dadan Ramadhan, Aoki-Utsubo Chie, Sri Hartati, Dewi Beti Ernawati, Hotta Hak

ADVANCED SCIENCE LETTERS, 24(9) 6807-6810, Sep, 2018 Peer-reviewed
Threonine-Allyl-Ester and Amide of Gallic Acid Derivative as Promising Anti-HCV Inhibitors

Apriyanto Dadan Ramadhan, Arsianti Ade, Aoki-Utsubo Chie, Fadilah, Bahtiar Anton, Dwira Surya, Paramita Rafika Indah, Hotta Hak

ADVANCED SCIENCE LETTERS, 24(8) 6265-6267, Aug, 2018 Peer-reviewed
Virucidal and Neutralizing Activity Tests for Antiviral Substances and Antibodies

Aoki-Utsubo Chie, Chen Ming, Hotta Hak

BIO-PROTOCOL, 8(10), May, 2018 Peer-reviewedLead author
Time-of-addition and Temperature-shift Assays to Determine Particular Step(s) in the Viral Life Cycle that is Blocked by Antiviral Substance(s)

Aoki-Utsubo Chie, Chen Ming, Hotta Hak

BIO-PROTOCOL, 8(9), May, 2018 Peer-reviewedLead author
Antiviral effect of archidendron pauciflorum leaves extract to hepatitis C virus: An in vitro study in JFH-1 strain

Sri Hartati, Chie Aoki, Muhammad Hanafi, Marissa Angelina, Pratiwi Soedarmono, Hak Hotta

Medical Journal of Indonesia, 27(1) 12-18, Mar 1, 2018 Peer-reviewed
Broad-spectrum antiviral agents: secreted phospholipase A(2) targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane

Ming Chen, Chie Aoki-Utsubo, Masanori Kameoka, Lin Deng, Yutaka Terada, Wataru Kamitani, Kei Sato, Yoshio Koyanagi, Makoto Hijikata, Keiko Shindo …

SCIENTIFIC REPORTS, 7(1) 15931, Nov, 2017 Peer-reviewed
Antiviral activity of the dichloromethane extracts from Artocarpus heterophyllus leaves against hepatitis C virus

Achmad Fuad Hafid, Chie Aoki-Utsubo, Adita Ayu Permanasari, Myrna Adianti, Lydia Tumewu, Aty Widyawaruyanti, Sri Puji Astuti Wahyuningsih, Tutik Sri Wahyuni, Maria Inge Lusida, Soetjipto …

Asian Pacific Journal of Tropical Biomedicine, 7(7) 633-639, Jul 1, 2017 Peer-reviewed
Synthesis and anti-hepatitis C virus activity of gallic acid derivatives with chiral center

Ade A, Aoki-Utsubo C, Fadilah F, Anton B, Dadan RA, Surya D, Novia AP, Hiroyuki T, Kiyomi K, Pratiwi S …

Asian Journal of Pharmaceutical and Clinical Research, 10(7) 164-167, 2017 Peer-reviewed
Anti-Hepatitis C Virus Activity of a Crude Extract from Longan (Dimocarpus longan Lour.) Leaves

Dadan Ramadhan Apriyanto, Chie Aoki, Sri Hartati, Muhammad Hanafi, Leonardus Broto Sugeng Kardono, Ade Arsianti, Melva Louisa, Tjahjani Mirawati Sudiro, Beti Ernawati Dewi, Pratiwi Sudarmono …

JAPANESE JOURNAL OF INFECTIOUS DISEASES, 69(3) 213-220, May, 2016 Peer-reviewedCorresponding author
AntiHepatitis C Virus Activity of Alectryon serratus Leaves Extract

Lidya Tumewu, Evhy Apryani, Mei Ria Santi, Tutik Sri Wahyuni, Adita Ayu Permanasari, Myrna Adianti, Chie Aoki, Aty Widyawaruyanti, Achmad Fuad Hafid, Maria Inge Lusida …

MOLECULAR AND CELLULAR LIFE SCIENCES: INFECTIOUS DISEASES, BIOCHEMISTRY AND STRUCTURAL BIOLOGY 2015 CONFERENCE, 18 169-173, 2016 Peer-reviewed
Activities of Ficus fistulosa Leave Extract and Fractions Against Hepatitis C Virus

Achmad Fuad Hafid, Adita Ayu Permanasari, Lidya Tumewu, Myrna Adianti, Chie Aoki, Aty Widyawaruyanti, Soetjipto, Maria Inge Lusida, Hak Hotta

MOLECULAR AND CELLULAR LIFE SCIENCES: INFECTIOUS DISEASES, BIOCHEMISTRY AND STRUCTURAL BIOLOGY 2015 CONFERENCE, 18 179-184, 2016 Peer-reviewed

Misc.

Antiviral Activity of Toad Cake and Its Compounds Bufalin and Gamabufotalin against Hepatitis C Virus and Dengue Virus

堀田博, 靭千恵, 西本幸子, 増井涼, 杉本智潮, 清水康晴, 須藤慶一, 河上仁美, 渕野裕之, 川原信夫 …

甲南女子大学研究紀要2, (16), 2022
Promising anti-hepatitis C virus compounds from natural resources

Wahyuni TS, Aoki Utsubo C, HOTTA HAK

Natural Product Communications, 11(8) 1193-1200, 2016 Peer-reviewedInvited
Syntheses and Biological Assay of a Series of Lacto-N-neotetraose Cluster using Carbosilane Dendrimer Scaffolds

Akihiro, Yamada, Ken Hatano, Koji Matsuoka, Yasuaki Esumi, Chie Aoki, Kazuya Hidari, Yasuo Suzuki, Daiyo Terunuma

The 14th International Symposium on Organosilicon Chemistry, 134, 2005
Isolation and characterization of glycolipids recognized with dengue virus type 2 from human and mosquito cells

KIPJ Hidari, C Aoki, T Ogi, S Itonori, F Hasebe, K Morita, M Sugita, T Takahashi, CT Guo, D Miyamoto …

GLYCOBIOLOGY, 14(11) 1158-1158, Nov, 2004

Presentations

新型コロナウイルスは肝細胞でアポリポプロテインBを利用して増殖する

Mar, 2023
硫酸単糖型抗デングウイルス薬の合成研究(3)

日本薬学

Mar, 2023
A biflavonid amentoflavone inhibits hepatitis B virus infection

Nov 16, 2021
A biflavonoid amentoflavone inhibits hepatitis B virus infection

Chie AOKI-UTSUBO, Indrasetiawan PUGUH, Kento FUKANO, Masamichi MURAMATSU, Masanori KAMEOKA, Hak HOTTA

Sep 20, 2021
Methyl-pheophorbide A and porphyrin derivatives inhibit the viral assembly step of hepatitis C virus

Chie Aoki-Utsubo, Masanori Kameoka, Hak Hotta

HCV2021: The International Symposium on Hepatitis C Virus and Related Viruses, Jul 7, 2021
新規デングウイルス感染阻害剤の合成（Ⅷ）

佐藤理貴、寺岡文照、靭千恵、左一八、大坪忠宗、池田潔

日本薬学会第140年会(京都), Mar 5, 2020
改変型糖鎖誘導体ライブラリーによるデングウイルス感染阻害効果の検討

靱千恵、寺岡文照、大坪忠宗、池田潔、左一八

日本薬学会第140年会(京都), Mar 5, 2020
A chlorophyll derivative, methyl-pheophorbide A inhibits hepatitis C virus assembly by affecting apolipoprotein production

Chie Aoki-Utsubo, Hak Hotta

第67回日本ウイルス学会学術集会, Oct, 2019
Antiviral Activity of Steroidal Cardiac Glycosides Obtained from Dried Toad Cake against Hepatitis C Virus

Hak Hotta, Chie Aoki-Utsubo, Sachiko Nishimoto, Hiroyuki Fuchino, Nobuo Kawahara, Ryo Masui, Chishio Sugimoto, Yasuharu Shimizu, Keiichi Sudo

第67回日本ウイルス学会学術集会, Oct, 2019
Further analysis of possible antiviral activity of CM-II-sPLA2 against HBV, HCV and HDV

Hak Hotta, Chie Aoki-Utsubo, Ming Chen, Sachiko Nishimoto, Lin Deng, Yohei Miyayama, Makoto Hijikata, Keiko Shindo, Takeshi Noda, Michinori Kohara, Senko Tsukuda, Koichi Watashi, Takaji Wakita

HBV2019 (International HBV Meeting), Oct, 2019
Potent Anti-HCV Activity of Bufalin and Gamabufotalin Obtained from Dried Toad Cake

Hak Hotta, Chie Aoki-Utsubo, Sachiko Nishimoto, Hiroyuki Fuchino, Nobuo Kawahara, Ryo Masui, Chishio Sugimoto, Yasuharu Shimizu, Keiichi Sudo

International Meeting on HCV and Related Viruses 2019, Oct, 2019
インドネシア原産薬用植物の抗B型肝炎ウイルス活性について

靱千恵, Puguh Indrasetiawan, Yan Mardiani, Muhammad Hanafi, Sri Hartati, Tutik Sri Wahyuni, 亀岡正典, 矢野嘉彦, 堀田博, 林祥剛

日本生薬学会第66年会, Sep, 2019
Methyl-pheophorbide AによるC型肝炎ウイルス感染性粒子形成阻害機構の解析

靱千恵, 堀田博

第139年回日本薬学会, Mar 22, 2019
A crude extract from Cananga odorata exhibits antiviral activity against hepatitis B virus.

Puguh Indrasetiawan, Chie Aoki-Utsubo, Muhammad Hanafi, Sri Hartati, Masanori Kameoka, Hak Hotta, Yoshitake Hayashi

第139年回日本薬学会, Mar 22, 2019
フッ素基導入型デングウイルス感染阻害剤の合成

向原大貴, 寺岡文照, 靱千恵, 左一八, 大坪忠宗, 池田潔

第139年会日本薬学会, Mar, 2019
動物生薬の抗HCV活性について

渕野裕之, 村瀬明香, 河上仁美, 川原信夫, 堀田博, 靭千恵, 増井涼, 杉本智潮, 清水康晴, 須藤慶一

第139年会日本薬学会, Mar, 2019
Supporting evidence that the ER/ERGIC is the main budding site for the Hepatitis B virus virion

陳明, 鄧琳, 靱千恵, 渡士幸一, 脇田隆字, 堀田博

第63回日本ウイルス会学術集会, Oct, 2018
Mechanistical study of antiviral activity of snake venom sPLA2 against HBV and HCV

Miyayama Yohei, Chen Ming, Aoki-Utsubo Chie, Deng Lin, Shido Keiko, Noda Takeshi, Kohara Michinori, Watashi Koichi, Wakita Takaji, Hijikata Makoto, Hotta Hak

第64回日本ウイルス会学術集会, Oct, 2018
Hepatitis C virus infection and screening research of potential antiviral agents from natural products

Chie Aoki-Utsubo

International Course for Health Sciences Summer Educational Program, Sep 8, 2018
Comparative analysis of antiviral activity of sPLA2 against HBV and HCV

Hotta H, Chen M, Aoki-Utsubo C, Deng L, Miyayama Y, Hijikata M, Shido K, Noda T, Kohara M, Watashi K, Wakita T

2018 HBV International meeting, 2018

Teaching Experience

Professional Memberships

Research Projects

新型コロナウイルス感染増殖における脂質代謝系の役割の解明

木下基礎科学研究基金助成事業, Aug, 2021 - Mar, 2023

靭千恵
インドネシアの薬用植物からの抗 B 型肝炎ウイルス新規リード化合物の探索と開発研究

二国間交流事業, 日本学術振興会, Apr, 2018 - Mar, 2021

靭千恵
インドネシア産植物に含まれるフェノール性水酸基化合物からの新規肝炎ウイルス治療薬シーズの探索

稲盛財団助成研究, Apr, 2018 - Sep, 2019

靭千恵
インドネシアにおける肝疾患の早期診断治療への教育システムの確立

科学研究費補助金／基盤研究(B), Apr, 2016 - Mar, 2019

林祥剛

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Papers

Misc.

Presentations

Teaching Experience

Professional Memberships

Research Projects

Menu

Coauthors