論文

査読有り 国際誌
2020年4月

Association of cholesterol uptake capacity, a novel indicator for HDL functionality, and coronary plaque properties: An optical coherence tomography-based observational study.

Clinica chimica acta; international journal of clinical chemistry
  • Toshihiko Oshita
  • ,
  • Ryuji Toh
  • ,
  • Yuichiro Nagano
  • ,
  • Koji Kuroda
  • ,
  • Yoshinori Nagasawa
  • ,
  • Amane Harada
  • ,
  • Katsuhiro Murakami
  • ,
  • Maria Kiriyama
  • ,
  • Keiko Yoshikawa
  • ,
  • Keiko Miwa
  • ,
  • Takuya Kubo
  • ,
  • Takuya Iino
  • ,
  • Manabu Nagao
  • ,
  • Yasuhiro Irino
  • ,
  • Tetsuya Hara
  • ,
  • Masakazu Shinohara
  • ,
  • Hiromasa Otake
  • ,
  • Toshiro Shinke
  • ,
  • Katsuyuki Nakajima
  • ,
  • Tatsuro Ishida
  • ,
  • Ken-Ichi Hirata

503
開始ページ
136
終了ページ
144
記述言語
英語
掲載種別
DOI
10.1016/j.cca.2020.01.001

BACKGROUND: Cholesterol efflux from atherosclerotic lesion is a key function of high-density lipoprotein (HDL). Recently, we established a simple, high-throughput, cell-free assay to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as "cholesterol uptake capacity (CUC)". OBJECTIVE: To clarify the cross-sectional relationship between CUC and coronary plaque properties. METHODS: We enrolled 135 patients to measure CUC and assess the morphological features of angiographic stenosis by optical coherence tomography (OCT). We estimated the extent of the lipid-rich plaque by multiplying the mean lipid arc by lipid length (lipid index). The extent of the OCT-detected macrophage accumulation in the target plaque was semi-quantitatively estimated using a grading system. RESULTS: Lipid-rich plaque lesions were identified in 125 patients (92.6%). CUC was inversely associated with the lipid index (R = -0.348, P < 0.0001). In addition, CUC was also inversely associated with macrophage score (R = -0.327, P < 0.0001). Conversely, neither circulating levels of HDL cholesterol nor apoA1 showed a similar relationship. CONCLUSIONS: We demonstrated that CUC was inversely related to lipid-rich plaque burden and the extent of macrophage accumulation, suggesting that CUC could be useful for cardiovascular risk stratification.

リンク情報
DOI
https://doi.org/10.1016/j.cca.2020.01.001
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31972150

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