論文

査読有り
2020年6月29日

Open-label multicenter registry on the outcomes of peripheral arterial disease treated by balloon angioplasty with optical frequency domain imaging in superficial femoral artery and popliteal artery (OCEAN-SFA study).

Cardiovascular intervention and therapeutics
  • Yoshiro Tsukiyama
  • ,
  • Akihide Konishi
  • ,
  • Toshiro Shinke
  • ,
  • Amane Kozuki
  • ,
  • Hiromasa Otake
  • ,
  • Hiroyuki Kawamori
  • ,
  • Kenichi Yanaka
  • ,
  • Osamu Iida
  • ,
  • Takayuki Ishihara
  • ,
  • Takumi Inoue
  • ,
  • Masamichi Iwasaki
  • ,
  • Makoto Kadotani
  • ,
  • Naoki Matsukawa
  • ,
  • Keiji Noutomi
  • ,
  • Yasumasa Kakei
  • ,
  • Isao Nanba
  • ,
  • Takashi Omori
  • ,
  • Junya Shite
  • ,
  • Ken-Ichi Hirata

記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s12928-020-00679-x

Although balloon angioplasty for femoropopliteal artery lesions has been associated with restenosis rates of up to 60% at 12 months, the mechanism of restenosis has not been fully evaluated. The aim of this study was to evaluate the relationship between the vascular features observed on optical frequency domain imaging (OFDI) before and after balloon angioplasty of femoropopliteal artery lesions, and restenosis at 6 months. This study was a prospective multicenter single arm study. OFDI was performed before and after balloon angioplasty and plaque characteristics and vascular features, along with de novo lesions, were assessed. The primary outcome was the presence or absence of restenosis 6 months after balloon angioplasty. Residual platelet reactivity was assessed according to VerifyNow platelet reactivity units (PRUs). The number of patients completing 6 months of follow-up was 47, of which 14 had developed restenosis. Maximum thickness of the dissection flap (odds ratio (OR) 2.71; 95% confidence interval [0.9-8.0]; p = 0.071) and lesion length were identified as risk factors for restenosis (OR 1.015; 95% confidence interval [0.001-0.029]; p = 0.039). The mean PRU at the time of treatment in patients with restenosis was significantly higher than in those without restenosis (286.3 ± 82.6 vs. 208.5 ± 03.6, p = 0.026). Long lesions and major dissection on OFDI after balloon angioplasty for femoropopliteal artery lesions increase restenosis at 6 months. In addition, high residual platelet reactivity at the time of EVT may also be a risk factor for restenosis.Clinical Trial Registration Number UMIN000021120.

リンク情報
DOI
https://doi.org/10.1007/s12928-020-00679-x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32601825

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