論文

査読有り
2017年5月

The Causal Relationship between DNA Damage Induction in Bovine Lymphocytes and the Fukushima Nuclear Power Plant Accident

RADIATION RESEARCH
  • Asako J. Nakamura
  • Masatoshi Suzuki
  • Christophe E. Redon
  • Yoshikazu Kuwahara
  • Hideaki Yamashiro
  • Yasuyuki Abe
  • Shintaro Takahashi
  • Tomokazu Fukuda
  • Emiko Isogai
  • William M. Bonner
  • Manabu Fukumoto
  • 全て表示

187
5
開始ページ
630
終了ページ
636
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1667/RR14630.1
出版者・発行元
RADIATION RESEARCH SOC

The Fukushima Daiichi Nuclear Power Plant (FNPP) accident, the largest nuclear incident since the 1986 Chernobyl disaster, occurred when the plant was hit by a tsunami triggered by the Great East Japan Earthquake on March 11, 2011. The subsequent uncontrolled release of radioactive substances resulted in massive evacuations in a 20-km zone. To better understand the biological consequences of the FNPP accident, we have been measuring DNA damage levels in cattle in the evacuation zone. DNA damage was evaluated by assessing the levels of DNA double-strand breaks in peripheral blood lymphocytes by immunocyto-fluorescence-based quantification of gamma-H2AX foci. A greater than two-fold increase in the fraction of damaged lymphocytes was observed in all animal cohorts within the evacuation zone, and the levels of DNA damage decreased slightly over the 700-day sample collection period. While the extent of damage appeared to be independent of the distance from the accident site and the estimated radiation dose from radiocesium, we observed age-dependent accumulation of DNA damage. Thus, this study, which was the first to evaluate the biological impact of the FNPP accident utilizing the gamma-H2AX assays, indicated the causal relation between high levels of DNA damage in animals living in the evacuation zone and the FNPP accident. (C) 2017 by Radiation Research Society

リンク情報
DOI
https://doi.org/10.1667/RR14630.1
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000400877200003&DestApp=WOS_CPL
ID情報
  • DOI : 10.1667/RR14630.1
  • ISSN : 0033-7587
  • eISSN : 1938-5404
  • Web of Science ID : WOS:000400877200003

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