Apr, 2014 - Mar, 2017
A study of materials property and osteoconductive capacity of bone substitutes
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)
- Grant number
- 26293417
- Japan Grant Number (JGN)
- JP26293417
- Authorship
- Coinvestigator(s)
- Grant amount
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- (Total)
- 16,510,000 Japanese Yen
- (Direct funding)
- 12,700,000 Japanese Yen
- (Indirect funding)
- 3,810,000 Japanese Yen
The present study was designed to investigate as to whether calcium phosphate in matrix polymer materials affects oriented bone formation. Octacalcium phosphate without the matrix stimulated macrophage-like cells migration. The presence of gelatin controls the crystallite size and the hydrolysis rate. Octacalcium phosphate in gelatin matrix affects the production of oriented bone formation in rat calvaria defect. The composite stimulated the formation of cortical bone having strength compatible to natural bone in rabbit tibia defect (push-in-test). The presence of octacalcium phosphate in the matrix material could be associated with the quality of newly formed bone.
- Link information
- ID information
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- Grant number : 26293417
- Japan Grant Number (JGN) : JP26293417