論文

2020年11月

Urine Lactoferrin as a Potential Biomarker Reflecting the Degree of Malignancy in Urothelial Carcinoma of the Bladder.

The Tohoku journal of experimental medicine
  • Eiri Matsumura
  • ,
  • Noritake Kosuge
  • ,
  • Shotaro Nakanishi
  • ,
  • Tetsuji Suda
  • ,
  • Ai Sugawa
  • ,
  • Tsutomu Fujimura
  • ,
  • Ryota Miyagi
  • ,
  • Naoki Yoshimi
  • ,
  • Seiichi Saito

252
3
開始ページ
225
終了ページ
244
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1620/tjem.252.225

Urothelial carcinoma of the bladder (UCB) is potentially life-threatening; therefore, we aimed to discover a novel urine biomarker for diagnosis and prognostication of UCB. This is a retrospective case-control study. Exploration of a new biomarker using urine from 20 UCB patients in the present study revealed that urinary level of lactoferrin (LF), a multifunctional glycoprotein released from neutrophils, was higher in 11 of 15 with invasive/high-grade UCB than 5 with non-invasive one, and 2 healthy adults. We therefore focused on LF and assessed the value of urine LF normalized by urine creatinine concentration (LF/Cr) using an enzyme-linked immunosorbent assay. Diagnostic performance of urine LF/Cr was examined using urine from 92 patients with primary (newly diagnosed) untreated UCB and 166 controls without UCB, including 62 patients with pyuria, and 104 subjects without pyuria consisting of 84 patients and 20 healthy adults. However, the diagnostic accuracies were accompanied by the risk of bias. In 92 primary UCB patients, both pyuria and tumor-infiltrating neutrophils (TINs) were independent predictors for urine LF/Cr. In contrast, TINs or urine LF/Cr were independent predictors for invasive histology, whereas pyuria was not. In terms of prognostication, urine LF/Cr and nodal metastasis were independent predictors of disease-specific survival in 22 patients with muscle-invasive bladder cancer, characterized by a high mortality rate, in the Cox proportional hazards model. In conclusion, urine LF/Cr linked to TINs was a predictor of both invasive histology and prognosis in UCB. Urine LF/Cr is a potential biomarker reflecting the degree of malignancy in UCB.

リンク情報
DOI
https://doi.org/10.1620/tjem.252.225
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33162487
ID情報
  • DOI : 10.1620/tjem.252.225
  • PubMed ID : 33162487

エクスポート
BibTeX RIS