田島一樹 (Kazuki Tajima) - マイポータル

基本情報

所属: 独立行政法人国立病院機構横浜医療センター糖尿病内分泌内科部長

学位: 医学博士(北海道大学)

J-GLOBAL ID: 201401093122018454
researchmap会員ID: 7000006813

論文

Post-translational control of beige fat biogenesis by PRDM16 stabilization

Qiang Wang, Huixia Li, Kazuki Tajima, Anthony R. P. Verkerke, Zachary H. Taxin, Zhishuai Hou, Joanne B. Cole, Fei Li, Jake Wong, Ichitaro Abe …

Nature 2022年8月17日査読有り
Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor.

Tomoko Okuyama, Jun Shirakawa, Kazuki Tajima, Yoko Ino, Heidrun Vethe, Yu Togashi, Mayu Kyohara, Ryota Inoue, Daisuke Miyashita, Jinghe Li …

International journal of molecular sciences 21(21) 2020年10月22日
CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.

Yasuo Oguri, Kosaku Shinoda, Hyeonwoo Kim, Diana L Alba, W Reid Bolus, Qiang Wang, Zachary Brown, Rachana N Pradhan, Kazuki Tajima, Takeshi Yoneshiro …

Cell 182(3) 563-577 2020年8月6日査読有り
The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT-liver communication.

Carlos H Sponton, Takashi Hosono, Junki Taura, Mark P Jedrychowski, Takeshi Yoneshiro, Qiang Wang, Makoto Takahashi, Yumi Matsui, Kenji Ikeda, Yasuo Oguri …

EMBO reports 21(9) e49828 2020年7月16日査読有り
Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis.

Kazuki Tajima, Kenji Ikeda, Yuji Tanabe, Ella A Thomson, Takeshi Yoneshiro, Yasuo Oguri, Marc D Ferro, Ada S Y Poon, Shingo Kajimura

Nature communications 11(1) 1730-1730 2020年4月7日査読有り
Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway.

Jun Shirakawa, Kazuki Tajima, Tomoko Okuyama, Mayu Kyohara, Yu Togashi, Dario F De Jesus, Giorgio Basile, Tatsuya Kin, A M James Shapiro, Rohit N Kulkarni …

Diabetologia 63(3) 577-587 2020年3月査読有り
Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis.

Kazuki Tajima, Kenji Ikeda, Hsin-Yi Chang, Chih-Hsiang Chang, Takeshi Yoneshiro, Yasuo Oguri, Heejin Jun, Jun Wu, Yasushi Ishihama, Shingo Kajimura

Nature metabolism 1(9) 886-898 2019年9月査読有り
BCAA catabolism in brown fat controls energy homeostasis through SLC25A44.

Takeshi Yoneshiro, Qiang Wang, Kazuki Tajima, Mami Matsushita, Hiroko Maki, Kaori Igarashi, Zhipeng Dai, Phillip J White, Robert W McGarrah, Olga R Ilkayeva …

Nature 572(7771) 614-619 2019年8月査読有り
Thermal stress induces glycolytic beige fat formation via a myogenic state.

Yong Chen, Kenji Ikeda, Takeshi Yoneshiro, Annarita Scaramozza, Kazuki Tajima, Qiang Wang, Kyeongkyu Kim, Kosaku Shinoda, Carlos Henrique Sponton, Zachary Brown …

Nature 565(7738) 180-185 2019年1月査読有り
Effects of SGLT2 Inhibition on eGFR and Glomerular and Tubular Damage Markers in Japanese Patients With Type 2 Diabetes

Hiromi Konishi, Jun Shirakawa, Kazuki Tajima, Tomoko Okuyama, Yu Togashi, Hikaru Takamine, Yoshinobu Kondo, Rieko Kunishita, Yasuo Terauchi

JOURNAL OF ENDOCRINOLOGY AND METABOLISM 8(5) 106-112 2018年10月
血糖管理増悪を契機に両側副腎褐色細胞腫の診断に至った1例

新井正法, 田島一樹, 花岡真由美, 室橋祐子, 細川紗帆, 寺内康夫

糖尿病 61(9) 628-628 2018年9月
Signaling between pancreatic β cells and macrophages via S100 calcium-binding protein A8 exacerbates β-cell apoptosis and islet inflammation.

Inoue H, Shirakawa J, Togashi Y, Tajima K, Okuyama T, Kyohara M, Tanaka Y, Orime K, Saisho Y, Yamada T …

The Journal of biological chemistry 293(16) 5934-5946 2018年4月20日査読有り
UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis.

Kenji Ikeda, Qianqian Kang, Takeshi Yoneshiro, Joao Paulo Camporez, Hiroko Maki, Mayu Homma, Kosaku Shinoda, Yong Chen, Xiaodan Lu, Pema Maretich …

Nature medicine 23(12) 1454-1465 2017年12月査読有り
Serum Quantitative Proteomic Analysis Reveals Soluble EGFR To Be a Marker of Insulin Resistance in Male Mice and Humans.

Kyohara M, Shirakawa J, Okuyama T, Kimura A, Togashi Y, Tajima K, Hirano H, Terauchi Y

Endocrinology 158(12) 4152-4164 2017年12月1日査読有り
Effects of metformin on compensatory pancreatic β-cell hyperplasia in mice fed a high-fat diet.

Tajima K, Shirakawa J, Okuyama T, Kyohara M, Yamazaki S, Togashi Y, Terauchi Y

American journal of physiology. Endocrinology and metabolism 313(3) E367-E380-E380 2017年9月1日査読有り
Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-906.

Tajima K, Shirakawa J, Togashi Y, Yamazaki S, Okuyama T, Kyohara M, Konishi H, Terauchi Y

Scientific reports 7(1) 4119-4119 2017年6月23日査読有り
Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.

Okuyama T, Shirakawa J, Yanagisawa H, Kyohara M, Yamazaki S, Tajima K, Togashi Y, Terauchi Y

Scientific reports 7(1) 2364-2364 2017年5月24日査読有り
GHRP-2負荷試験による視床下部下垂体副腎系機能評価に関する検討

近藤義宣, 新井正法, 室橋祐子, 細川紗帆, 田島一樹, 富樫優, 伊藤譲, 寺内康夫

日本内分泌学会雑誌 93(1) 264-264 2017年4月
先端巨大症に合併したPlummer病の1例

池上充, 室橋祐子, 新井正法, 細川紗帆, 田島一樹, 寺内康夫

日本内科学会関東地方会 631回 33-33 2017年3月
抗ラブフィリン3A抗体による中枢性尿崩症を合併した全身性エリテマトーデスの一例

大原亜沙実, 西村謙一, 野澤智, 菊地雅子, 原良紀, 田島一樹, 寺内康夫, 岩間信太郎, 椙村益久, 伊藤秀一

日本小児リウマチ学会総会・学術集会プログラム・抄録集 26回 69-69 2016年10月査読有り

もっとみる

MISC

Comparison of efficacy and safety of taking miglitol dissolved in water during a meal and taking a miglitol tablet just before a meal in patients with type 2 diabetes

Eriko Shibata, Kazutaka Aoki, Kazuki Tajima, Masataka Taguri, Yasuo Terauchi

EXPERT OPINION ON PHARMACOTHERAPY 17(7) 889-894 2016年
The role of S100A8 and S100A9 in inflammatory interaction between pancreatic islets and macrophages

H. Inoue, J. Shirakawa, K. Orime, Y. Togashi, K. Tajima, Y. Terauchi

DIABETOLOGIA 57 S304-S304 2014年9月
β-Cell proliferation after a partial pancreatectomy is independent of irs-2 in mice

Endocrinology 155(5) 1643-52 2014年5月
Effects of miglitol, vildagliptin, or their combination on serum insulin and peptide YY levels and plasma glucose, cholecystokinin, ghrelin, and obestatin levels

Kazutaka Aoki, Hiroshi Kamiyama, Kiyomi Masuda, Kazunari Kamiko, Yoshihiko Noguchi, Kazuki Tajima, Yasuo Terauchi

Endocrine Journal 61(3) 249-256 2014年
Role of insulin receptor substrate-1 for diethylnitrosamine plus high-fat diet-induced hepatic tumorigenesis in mice

Khadbaatar Zolzaya, Akinobu Nakamura, Kazuki Tajima, Yasuo Terauchi

JOURNAL OF DIABETES INVESTIGATION 5(1) 27-30 2014年1月
Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic β-cells

Diabetes 62(10) 3448-58 2013年10月
Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice

K. Tajima, A. Nakamura, J. Shirakawa, Y. Togashi, K. Orime, K. Sato, H. Inoue, M. Kaji, E. Sakamoto, Y. Ito …

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 305(8) E987-E998 2013年10月
Comparative study of sitagliptin with pioglitazone in Japanese type 2 diabetic patients: the COMPASS randomized controlled trial

M. Takihata, A. Nakamura, K. Tajima, T. Inazumi, Y. Komatsu, H. Tamura, S. Yamazaki, Y. Kondo, M. Yamada, M. Kimura …

DIABETES OBESITY & METABOLISM 15(5) 455-462 2013年5月
Trefoil factor 2 promotes cell proliferation in pancreatic β-cells through CXCR-4-mediated ERK1/2 phosphorylation

Endocrinology 154(1) 54-64 2013年1月
AMPK is involved in the regulation of incretin receptors expression in pancreatic islets under a low glucose concentration.

Kazuki Tajima, Jun Shirakawa, Yu Togashi, Hideaki Inoue, Koichiro Sato, Kazuki Orime, Yuzuru Ito, Mitsuyo Kaji, Eri Sakamoto, Akinobu Nakamura …

PloS one 8(5) e64633 2013年
Protection from non-alcoholic steatohepatitis and liver tumourigenesis in high fat-fed insulin receptor substrate-1-knockout mice despite insulin resistance

A. Nakamura, K. Tajima, K. Zolzaya, K. Sato, R. Inoue, M. Yoneda, K. Fujita, Y. Nozaki, K. C. Kubota, H. Haga …

DIABETOLOGIA 55(12) 3382-3391 2012年12月
Effects of liraglutide on β-cell-specific glucokinase- deficient neonatal mice

Endocrinology 153(7) 3066-75 2012年7月
Plasminogen activator inhibitor-1 is associated with renal dysfunction independent of BMI and serum lipid levels in patients with type 2 diabetes.

Jun Shirakawa, Yu Togashi, Kazuki Tajima, Kazuki Orime, Kaori Kikuchi, Takashi Miyazaki, Koichiro Sato, Mari Kimura, Yoshio Goshima, Yasuo Terauchi

Diabetes research and clinical practice 97(1) e9-12 2012年7月
Plasminogen activator inhibitor-1 is associated with renal dysfunction independent of BMI and serum lipid levels in patients with type 2 diabetes.

Jun Shirakawa, Yu Togashi, Kazuki Tajima, Kazuki Orime, Kaori Kikuchi, Takashi Miyazaki, Koichiro Sato, Mari Kimura, Yoshio Goshima, Yasuo Terauchi

Diabetes research and clinical practice 97(1) e9-12 2012年7月
Comparative Study of Sitagliptin With Pioglitazone for Strict Glycemic Control: The COMPASS Study

Masahiro Takihata, Akinobu Nakamura, Kazuki Tajima, Takaharu Inazumi, Yumiko Komatsu, Haruka Tamura, Syunsuke Yamazaki, Yoshinobu Kondou, Masayo Yamada, Mari Kimura …

DIABETES 61 A256-A256 2012年6月
Regulation of Expression of Incretin Receptors In Islet by Dephosphorylation of AMPK

Kazuki Tajima, Jun Shirakawa, Kazuki Orime, Yu Togashi, Yasuo Terauchi

DIABETES 61 A543-A543 2012年6月
Trefoil Factor 2 Promotes Cell Proliferation in Pancreatic B Cells Through a Cxcr4-Mediated Erk1/2 Pathway

Kazuki Orime, Jun Shirakawa, Akinobu Nakamura, Kazuki Tajima, Yu Togashi, Yasuo Terauchi

DIABETES 61 A530-A530 2012年6月
PrediabetesとNASHとの関連

中村昭伸, 米田正人, 藤田浩司, 田島一樹, 菊地香織, 中島淳, 前田愼, 寺内康夫

日本内科学会雑誌 101(Suppl.) 348-348 2012年2月
Impact of glucose tolerance on the severity of non-alcoholic steatohepatitis

Akinobu Nakamura, Masato Yoneda, Koji Fujita, Kazuki Tajima, Kaori Kikuchi, Atsushi Nakajima, Shin Maeda, Yasuo Terauchi

JOURNAL OF DIABETES INVESTIGATION 2(6) 483-489 2011年12月
Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes

Journal of Biological Chemistry 286(29) 25467-76 2011年7月22日

もっとみる

共同研究・競争的資金等の研究課題

メトホルミンによる膵β細胞保護機構の解明

日本学術振興会科学研究費助成事業若手研究(B) 2017年4月 - 2019年3月

田島一樹
グルコキナーゼ活性化による膵β細胞の運命決定

日本学術振興会科学研究費助成事業基盤研究(B) 2016年4月 - 2019年3月

寺内康夫, 伊藤譲, 富樫優, 白川純, 田島一樹, 田島一樹
メトホルミンによる膵β細胞保護作用の分子機構の解明

日本学術振興会科学研究費助成事業若手研究(B) 2015年4月 - 2017年3月

田島一樹