Tadashi Nakagawa

Profile Information

Affiliation: Assistant Professor, Graduate School of Medicine United Centers for Advanced Research and Translational Medicine Center for Cancer Research Cell proliferation, Tokyo University of Science,Yamaguchi
: Tohoku University

Degree: 博士（医学）(Mar, 2008, Kyushu University)

Researcher number: 30707013
J-GLOBAL ID: 201401061522238659
researchmap Member ID: 7000006956

External link: http://db.tohoku.ac.jp/whois/e_detail/bf3064b8defea88a3dbb225cbca93a47.html

Research Interests

Research Areas

Research History

Apr, 2020 - Present

Tohoku University
Apr, 2020 - Present

Junior Associate Professor, Department of Clinical Pharmacology, Sanyo-Onoda City University
Apr, 2013 - Mar, 2020

Assistant Professor, Division of Cell Proliferation, Graduate School of Medicine, Tohoku University
Apr, 2008 - Mar, 2013

Post-doctoral fellow, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill

Education

Apr, 2004 - Mar, 2008

Medical Instutute of Bioregulation, Graduate School of Medicine, Kyushu University
Apr, 2002 - Mar, 2004

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
Apr, 1998 - Mar, 2002

Department of Pharmaceutical Science, Hokkaido University

Committee Memberships

Apr, 2020 - Present

環境安全センター運営委員, 山陽小野田市立山口東京理科大学
Nov, 2014 - Mar, 2020

安全衛生委員, 東北大学大学院医学系研究科

Awards

Papers

SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones.

Tadashi Nakagawa, Akane Morohoshi, Yuko Nagasawa, Makiko Nakagawa, Masaki Hosogane, Yasuhiro Noda, Toru Hosoi, Keiko Nakayama

Cell reports, 38(12) 110541-110541, Mar 22, 2022
Neurobehavioral characteristics of mice with SETD5 mutations as models of IDD23 and KBG syndromes.

Tadashi Nakagawa, Satoko Hattori, Toru Hosoi, Keiko Nakayama

Frontiers in genetics, 13 1022339-1022339, 2022
Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations.

Shio Mitsuzawa, Naoki Suzuki, Tetsuya Akiyama, Mitsuru Ishikawa, Takefumi Sone, Jiro Kawada, Ryo Funayama, Matsuyuki Shirota, Hiroaki Mitsuhashi, Satoru Morimoto …

Stem cell reports, 16(6) 1527-1541, Jun 8, 2021 Peer-reviewed
USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2.

Lei-Lei Chen, Matthew D Smith, Lei Lv, Tadashi Nakagawa, Zhijun Li, Shao-Cong Sun, Nicholas G Brown, Yue Xiong, Yan-Ping Xu

Science advances, 6(38), Sep, 2020 Peer-reviewed
An Amyotrophic Lateral Sclerosis-Associated Mutant of C21ORF2 Is Stabilized by NEK1-Mediated Hyperphosphorylation and the Inability to Bind FBXO3.

Yasuaki Watanabe, Tadashi Nakagawa, Tetsuya Akiyama, Makiko Nakagawa, Naoki Suzuki, Hitoshi Warita, Masashi Aoki, Keiko Nakayama

iScience, 23(9) 101491-101491, Aug 21, 2020 Peer-reviewed
The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression.

Tadashi Nakagawa, Satoko Hattori, Risa Nobuta, Ryuichi Kimura, Makiko Nakagawa, Masaki Matsumoto, Yuko Nagasawa, Ryo Funayama, Tsuyoshi Miyakawa, Toshifumi Inada …

iScience, 23(4) 101030-101030, Apr 6, 2020 Peer-reviewed
Knockout Mouse Models Provide Insight into the Biological Functions of CRL1 Components.

Tadashi Nakagawa, Keiko Nakayama, Keiichi I Nakayama

Advances in experimental medicine and biology, 1217 147-171, 2020 Peer-reviewed
Pathogenic mutations in the ALS gene CCNF cause cytoplasmic mislocalization of Cyclin F and elevated VCP ATPase activity.

Yujiao Yu, Tadashi Nakagawa, Akane Morohoshi, Makiko Nakagawa, Noriko Ishida, Naoki Suzuki, Masashi Aoki, Keiko Nakayama

Human molecular genetics, 28(20) 3486-3497, Oct 15, 2019 Peer-reviewed
Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons.

Tetsuya Akiyama, Naoki Suzuki, Mitsuru Ishikawa, Koki Fujimori, Takefumi Sone, Jiro Kawada, Ryo Funayama, Fumiyoshi Fujishima, Shio Mitsuzawa, Kensuke Ikeda …

EBioMedicine, 45 362-378, Jul, 2019 Peer-reviewed
The ubiquitin ligase subunit β-TrCP in Sertoli cells is essential for spermatogenesis in mice.

Morohoshi A, Nakagawa T, Nakano S, Nagasawa Y, Nakayama K

Developmental biology, 445(2) 178-188, Jan, 2019 Peer-reviewed
Vpr Targets TET2 for Degradation by CRL4VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication

Lei Lv, Qi Wang, Yanping Xu, Li-Chung Tsao, Tadashi Nakagawa, Haitao Guo, Lishan Su, Yue Xiong

Molecular Cell, 70(5) 961-970.e5, Jun 7, 2018 Peer-reviewed
Prospective cohort study for identification of underlying genetic causes in neonatal encephalopathy using whole-exome sequencing

Theodora U J Bruun, Caro-Lyne Desroches, Diane Wilson, Vann Chau, Tadashi Nakagawa, Masahiro Yamasaki, Shinya Hasegawa, Toshiyuki Fukao, Christian Marshall, Saadet Mercimek-Andrews

Genetics in Medicine, 20(5) 486-494, Apr 1, 2018 Peer-reviewed
Transforming growth factor β-induced proliferative arrest mediated by TRIM26- dependent TAF7 degradation and its antagonism by MYC

Tadashi Nakagawa, Masaki Hosogane, Makiko Nakagawa, Akane Morohoshi, Ryo Funayama, Keiko Nakayama

Molecular and Cellular Biology, 38(5), Mar 1, 2018 Peer-reviewed
Regulation of mitosis-meiosis transition by the ubiquitin ligase beta-TrCP in male germ cells

Tadashi Nakagawa, Teng Zhang, Ryo Kushi, Seiji Nakano, Takahiro Endo, Makiko Nakagawa, Noriko Yanagihara, David Zarkower, Keiko Nakayama

DEVELOPMENT, 144(22) 4137-4147, Nov, 2017 Peer-reviewed
Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair

Noriko Ishida, Tadashi Nakagawa, Shun-Ichiro Iemura, Akira Yasui, Hiroki Shima, Yasutake Katoh, Yuko Nagasawa, Toru Natsume, Kazuhiko Igarashi, Keiko Nakayama

MOLECULAR AND CELLULAR BIOLOGY, 37(4), Feb, 2017 Peer-reviewed
The SCF beta-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis

Kouhei Shimizu, Hidefumi Fukushima, Kohei Ogura, Evan C. Lien, Naoe Taira Nihira, Jinfang Zhang, Brian J. North, Ailan Guo, Katsuyuki Nagashima, Tadashi Nakagawa …

SCIENCE SIGNALING, 10(460), Jan, 2017 Peer-reviewed
S6 Kinase- and beta-TrCP2-Dependent Degradation of p19(Arf) Is Required for Cell Proliferation

Tadashi Nakagawa, Takaaki Araki, Makiko Nakagawa, Atsushi Hirao, Michiaki Unno, Keiko Nakayama

MOLECULAR AND CELLULAR BIOLOGY, 35(20) 3517-3527, Oct, 2015 Peer-reviewed
Protein monoubiquitylation: Targets and diverse functions

Tadashi Nakagawa, Keiko Nakayama

Genes to Cells, 20(7) 543-562, Jul 1, 2015 Peer-reviewed
Variants in CUL4B are Associated with Cerebral Malformations

Anneke T. Vulto-van Silfhout, Tadashi Nakagawa, Nadia Bahi-Buisson, Stefan A. Haas, Hao Hu, Melanie Bienek, Lisenka E. L. M. Vissers, Christian Gilissen, Andreas Tzschach, Andreas Busche …

HUMAN MUTATION, 36(1) 106-117, Jan, 2015 Peer-reviewed
CRL4(VprBP) E3 Ligase Promotes Monoubiquitylation and Chromatin Binding of TET Dioxygenases

Tadashi Nakagawa, Lei Lv, Makiko Nakagawa, Yanbao Yu, Chao Yu, Ana C. D'Alessio, Keiko Nakayama, Heng-Yu Fan, Xian Chen, Yue Xiong

MOLECULAR CELL, 57(2) 247-260, Jan, 2015 Peer-reviewed

Misc.

Prospective Cohort Study for Identification of Underlying Genetic Causes in Neonatal Encephalopathy Using Whole-Exome Sequencing

Theodora U.J. Bruun, Caro Lyne Desroches, Diane Wilson, Vann Chau, Tadashi Nakagawa, Masahiro Yamasaki, Shinya Hasegawa, Toshiyuki Fukao, Christian Marshall, Saadet Mercimek-Andrews

Obstetrical and Gynecological Survey, 73(10) 564-565, Oct 1, 2018
CRL4(VprBP) E3 Ligase Promotes Monoubiquitylation and Chromatin Binding of TET Dioxygenases (vol 342, pg 1518, 2013)

Tadashi Nakagawa, Lei Lv, Makiko Nakagawa, Yanbao Yu, Chao Yu, Ana C. D'Alessio, Keiko Nakayama, Heng-Yu Fan, Xian Chen, Yue Xiong

MOLECULAR CELL, 59(6), Sep, 2015
ユビキチンリガーゼ複合体CRL4VprBPはTETタンパク質のモノユビキチン化およびクロマチンとの結合を促進する

中川直, 中山啓子, Yue Xiong

ライフサイエンス新着論文レビュー "http://first.lifesciencedb.jp/archives/9768", 2015 Invited
X染色体性知的障害の原因タンパク質CUL4BはWDR5のユビキチン化にはたらくことで神経に特異的な遺伝子の発現を制御する

中川直, Yue Xiong

ライフサイエンス新着論文レビュー "http://first.lifesciencedb.jp/archives/3507", 2011 Invited
X-linked intellectual disability gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression.

Tadashi Nakagawa

30 1076-1077, 2011 Invited
UFD pathway

Tadashi Nakagawa

Proteins, nucleic acids and enzymes "Ubiquitin―Proteasome system and autophagy", 51 1190, 2006 Invited

Presentations

Autism-related protein SETD5 controls neural proliferation by epigenetic regulation of rDNA expression

Tadashi Nakagawa, Keiko Nakayama

The 10th Takeda Science Foundation Symposium on PharmaSciences, Jan 24, 2020
Epigenetic regulation of rDNA by intellectual disability and autism-related protein SETD5

Tadashi Nakagawa, Keiko Nakayama

The 42th annual meeting of the molecular biology society of Japan, Dec 3, 2019
Pathogenesis of ALS by impaired protein degradation

Yasuaki Watanabe, Tadashi Nakagawa, Naoki Suzuki, Hitoshi Warita, Keiko Nakayama, Masashi Aoki

42th Annual meeting of the Japan Neuroscience Society, Jul 25, 2019
Mutation of cyclin F may contribute to Amyotrophic Lateral Sclerosis pathogenesis by affecting VCP ATPase activity

Yujian Yu, Akane Morohoshi, Tadashi Nakagawa, Keiko nakayama

41th Annual meeting of the molecular biology society of Japan, Nov 29, 2018
Regulation of FACT complex by ubiquitylation

Tadashi Nakagawa, Keiko Nakayama

41th Annual meeting of the molecular biology society of Japan, Nov 29, 2018 Invited
Regulation of histone chaperon FACT by ubiquitylation

Tadashi Nakagawa, Akane Morohoshi, Keiko Nakayama

Special lecture on the 5th anniversary of the Tohoku Forum for Creativity "Genome Editing", Jul 29, 2018
ALS-associated C21ORF2 mutation enhances the autoregulation mechanism of NEK1

Yasuaki Watanabe, Tadashi Nakagawa, Naoki Suzuki, Hitoshi Warita, Keiko Nakayama, Masashi Aoki

59th General meeting of the Japanese Society of Neurology, May 23, 2018
Regulation of mitosis-meiosis transition of male germ cells by β-TrCP

Tadashi Nakagawa, Keiko Nakayama

40th Annual meeting of the molecular biology society of Japan, Dec 8, 2017
VCP affects formation of cytosolic TDP-43 aggregationaaa

Yujiao Yu, Tadashi Nakagawa, Keiko Nakayama

40th Annual meeting of the molecular biology society of Japan, Dec 7, 2017
Regulation of mitosis-meiosis transition of male germ cells by β-TrCP

Tadashi Nakagawa, Seiji Nakano, Ryo kushi, Keiko Nakayama

Advanced model animal support platform young technical support workshop, Sep 8, 2017
Interplay of MYC oncogene and ubiquitin-proteasomal degradation of a TFIID component in proliferation switch

Tadashi Nakagawa

The 2017 Japan-NIH Joint Symposium. 2017, Feb 17, 2017 Invited
Regulation of FACT complex by ubiquitylation

Akane Morohoshi, Tadashi Nakagawa, Keiko Nakayama

39th Annual meeting of the molecular biology society of Japan, Dec 1, 2016
Molecular analysis of Amyotrophic Lateral Sclerosis associated Cyclin F mutants

Yujiao Yu, Akane Morohoshi, Tadashi Nakagawa, Keiko Nakayama

39th Annual meeting of the molecular biology society of Japan, Dec 1, 2016
Reactivation of cell proliferation by continuous TGF-β treatment

Tadashi Nakagawa, Masaki Hosogane, Ryo Funayama, Keiko Nakayama

39th Annual meeting of the molecular biology society of Japan, Nov 30, 2016
Analysis of Sertoli cell-specific β-TrCP knockout mice

Akane Morohoshi, Tadashi Nakagawa, Seiji Nakano, Keiko Nakayama

38th Annual meeting of the molecular biology society of Japan, Dec 1, 2015
TGF-β-induced degradation of TFIID component TAF7

Tadashi Nakagawa, Masaki Hosogane, Ryo Funayama, Keiko Nakayama

38th Annual meeting of the molecular biology society of Japan, Dec 1, 2015
Identification and characterization of E3 ligase β-TrCP substrates in spermatogenesis

Ryo Kushi, Tadashi Nakagawa, Seiji Nakano, Naohiro Endo, Keiko Nakayama

37th Annual meeting of the molecular biology society of Japan, Nov 25, 2014
TFIID complex changes accompany epithelial-mesenchymal transition (EMT)

Tadashi Nakagawa, Keiko Nakayama

37th Annual meeting of the molecular biology society of Japan, Nov 25, 2014
Regulation of cell proliferation by β-TrCP2-mediated degradation of p19Arf

Tadashi Nakagawa

20th Cancer-epigenome study group, Apr 23, 2014 Invited
Regulation of FACT complex by ubiquitylation

Akane Morohoshi, Tadashi Nakagawa, Keiko Nakayama

36th Annual meeting of the molecular biology society of Japan, Dec 5, 2013

Teaching Experience

Professional Memberships

日本分子生物学会

Research Projects

Do Food Additives Cause Obesity?-Elucidation of the mechanism of action on leptin receptor signaling-

Grants-in-Aid for Scientific Research, Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)), Japan Society for the Promotion of Science, Oct, 2022 - Mar, 2025
SETD5の膵臓癌における機能

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2021 - Mar, 2024

中山啓子, 舟山亮, 中川直, 細金正樹
DNA損傷時のユビキチンリガーゼRNF126による転写制御メカニズムの解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

石田典子, 中川直
Functional analysis of ubiquitin ligase RNF126

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2021

Ishida Noriko
Elucidation of the signaling pathways that induce gene amplification

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2020

NAKAYAMA Keiko
Investigation of novel ALS/FTLD therapeutics that target RNA

Kaken, Apr, 2019

Tadashi Nakagawa
Development of RNA-targeted novel therapeutics against ALS

Kaken, Apr, 2017 - Mar, 2019

Tadashi Nakagawa
Elucidation of protein degradation-mediated ALS pathogenesis regulated by cytosolic RNA

Kaken, Apr, 2015 - Mar, 2017

Tadashi Nakagawa
Verification of genomic diversity required for tumorigenesis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2016

NAKAYAMA KEIKO, FUNAYAMA RYO, NAKAGAWA TADASHI, HOSOGANE MASAKI
Elucidation of novel regulatory mechanism of basic transcription factor during cell differentiation

Kaken, Sep, 2013 - Mar, 2015

Tadashi Nakagawa

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Papers

Misc.

Presentations

Teaching Experience

Professional Memberships

Research Projects

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Coauthors