Mika Sakurai

Profile Information

Affiliation: Assistant Professor, Tohoku Medical Megabank Organization, Tohoku University

Degree: 医学博士(東京大学)

Researcher number: 80508359
J-GLOBAL ID: 201401034116152908
researchmap Member ID: 7000007016

Research Interests

Research Areas

Research History

Mar, 2018 - Present

Tohoku Medical Megabank Organization, Tohoku University
Apr, 2017 - Feb, 2018

Tohoku Medical Megabank Organization, Tohoku University
Apr, 2015 - Mar, 2017

主幹, 日本医療研究開発機構
Sep, 2013 - Mar, 2015

Tohoku Medical Megabank Organization, Tohoku University
Nov, 2007 - Aug, 2013

The Institute of Medical Science, The University of Tokyo
Sep, 2007 - Nov, 2007

The Institute of Medical Science, The University of Tokyo
Apr, 2005 - Aug, 2007

ポストドクトラルフェロー, キュリー研究所
Apr, 2003 - Mar, 2005

リサーチレジデント, 国立がんセンター研究所

Education

Apr, 1999 - Mar, 2003

The University of Tokyo
Apr, 1997 - Mar, 1999

Graduate School of Industrial Science and Technology, Tokyo University of Science
Apr, 1993 - Mar, 1997

Faculty of Industrial Science and Technology, Tokyo University of Science

Papers

The Health History of First-Degree Relatives’ Dyslipidemia Can Affect Preferences and Intentions following the Return of Genomic Results for Monogenic Familial Hypercholesterolemia

Tomoharu Tokutomi, Akiko Yoshida, Akimune Fukushima, Kayono Yamamoto, Yasushi Ishigaki, HIROSHI KAWAME, Nobuo Fuse, Fuji Nagami, Yoichi Suzuki, Mika Sakurai-Yageta …

Genes, Mar 21, 2024 Peer-reviewed
Study Profile of the Tsuruoka Metabolomics Cohort Study (TMCS)

Sei Harada, Miho Iida, Naoko Miyagawa, Aya Hirata, Kazuyo Kuwabara, Minako Matsumoto, Tomonori Okamura, Shun Edagawa, Yoko Kawada, Atsuko Miyake …

Journal of Epidemiology, Jan, 2024 Peer-reviewed
Trans-homophilic interaction of CADM1 promotes organ infiltration of T-cell lymphoma by adhesion to vascular endothelium.

Yutaka Kasai, Siew Pey Gan, Toko Funaki, Yuki Ohashi-Kumagai, Mizuki Tominaga, Shu-Jen Shiu, Daisuke Suzuki, Daisuke Matsubara, Takeharu Sakamoto, Mika Sakurai-Yageta …

Cancer science, 113(5) 1669-1678, May, 2022
A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants.

Kinuko Ohneda, Masahiro Hiratsuka, Hiroshi Kawame, Fuji Nagami, Yoichi Suzuki, Kichiya Suzuki, Akira Uruno, Mika Sakurai-Yageta, Yohei Hamanaka, Makiko Taira …

JMA journal, 5(2) 177-189, Apr 15, 2022
dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project.

Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura …

Human genome variation, 8(1) 44-44, Dec 10, 2021
Construction and integration of three de novo Japanese human genome assemblies toward a population-specific reference

Jun Takayama, Shu Tadaka, Kenji Yano, Fumiki Katsuoka, Chinatsu Gocho, Takamitsu Funayama, Satoshi Makino, Yasunobu Okamura, Atsuo Kikuchi, Sachiyo Sugimoto …

Nature Communications, 12(1), Dec, 2021
Association between Serum Biotin Levels and Cedar Pollinosis in Japanese Schoolchildren

Mika SAKURAI-YAGETA, Yoichi MASHIMO, Toshinobu KUROISHI, Rino ISHIHARA, Naoki SHIMOJO, Yoichi KOHNO, Yoshitaka OKAMOTO, Akira HATA, Yoichi SUZUKI

Journal of Nutritional Science and Vitaminology, 67(4) 211-216, Aug 31, 2021
The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project.

Hiroshi Kawame, Akimune Fukushima, Nobuo Fuse, Fuji Nagami, Yoichi Suzuki, Mika Sakurai-Yageta, Jun Yasuda, Yumi Yamaguchi-Kabata, Kengo Kinoshita, Soichi Ogishima …

Journal of human genetics, 67(1) 9-17, Jul 8, 2021
Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs

Mika Sakurai-Yageta, Kazuki Kumada, Chinatsu Gocho, Satoshi Makino, Akira Uruno, Shu Tadaka, Ikuko N Motoike, Masae Kimura, Shin Ito, Akihito Otsuki …

The Journal of Biochemistry, May 13, 2021
Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project

Akito Tsuboi, Hiroyuki Matsui, Naru Shiraishi, Takahisa Murakami, Akihito Otsuki, Junko Kawashima, Tomomi Kiyama, Toru Tamahara, Maki Goto, Shihoko Koyama …

The Tohoku Journal of Experimental Medicine, 251(2) 97-115, 2020
Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population.

Low SK, Chin YM, Ito H, Matsuo K, Tanikawa C, Matsuda K, Saito H, Sakurai-Yageta M, Nakaya N, Shimizu A …

Scientific reports, 9(1) 17332-17332, Nov, 2019 Peer-reviewed
Establishment of Integrated Biobank for Precision Medicine and Personalized Healthcare: The Tohoku Medical Megabank Project.

Fuse N, Sakurai-YagetaM, Katsuoka F, Danjoh I, Shimizu R, Tamiya G, Nagami F, Kawame H, Higuchi S, Kinoshita K …

JMA Journal, 2(2) 113-122, Sep, 2019 Peer-reviewed
Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): Rationale, Progress and Perspective.

Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Masato Nagai, Hiroko Matsubara, Tomoko Kobayashi, Junichi Sugawara …

International journal of epidemiology, Aug 25, 2019 Peer-reviewed
A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization.

Mika Sakurai-Yageta, Hiroshi Kawame, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Fuji Nagami, Naoko Minegishi, Soichi Ogishima, Takako Takai-Igarashi, Inaho Danjoh …

BMC Medical Education, 19(1) 297, Aug, 2019 Peer-reviewed
Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare.

Jun Yasuda, Kengo Kinoshita, Fumiki Katsuoka, Inaho Danjoh, Mika Sakurai-Yageta, Ikuko N Motoike, Yoko Kuroki, Sakae Saito, Kaname Kojima, Matsuyuki Shirota …

Journal of biochemistry, 165(2) 139-158, Feb 1, 2019 Peer-reviewed
3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome.

Shu Tadaka, Fumiki Katsuoka, Masao Ueki, Kaname Kojima, Satoshi Makino, Sakae Saito, Akihito Otsuki, Chinatsu Gocho, Mika Sakurai-Yageta, Inaho Danjoh …

Human genome variation, 6(28) 28-28, 2019 Peer-reviewed
Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project

Naoko Minegishi, Ichiko Nishijima, Takahiro Nobukuni, Hisaaki Kudo, Noriko Ishida, Takahiro Terakawa, Kazuki Kumada, Riu Yamashita, Fumiki Katsuoka, Soichi Ogishima …

The Tohoku Journal of Experimental Medicine, 248(1) 45-55, 2019 Peer-reviewed
Regional genetic differences among Japanese populations and performance of genotype imputation using whole-genome reference panel of the Tohoku Medical Megabank Project.

Jun Yasuda, Fumiki Katsuoka, Inaho Danjoh, Yosuke Kawai, Kaname Kojima, Masao Nagasaki, Sakae Saito, Yumi Yamaguchi-Kabata, Shu Tadaka, Ikuko N Motoike …

BMC genomics, 19(1) 551-551, Jul 24, 2018 Peer-reviewed
The Tohoku Medical Megabank Project: Design and Mission

Shinichi Kuriyama, Nobuo Yaegashi, Fuji Nagami, Tomohiko Arai, Yoshio Kawaguchi, Noriko Osumi, Masaki Sakaida, Yoichi Suzuki, Keiko Nakayama, Hiroaki Hashizume …

JOURNAL OF EPIDEMIOLOGY, 26(9) 493-511, Sep, 2016 Peer-reviewed
Erratum to: Induction of the Matrix Metalloproteinase 13 Gene in Bronchial Epithelial Cells by Interferon and Identification of its Novel Functional Polymorphism.

Mashimo Y, Sakurai-Yageta M, Watanabe M, Arima T, Morita Y, Inoue Y, Sato K, Nishimuta T, Suzuki S, Watanabe H …

Inflammation, 39(3) 963, Jun, 2016 Peer-reviewed

Misc.

東北メディカル・メガバンク計画における遺伝情報返却の課題

濱中洋平, 濱中洋平, 大根田絹子, 布施昇男, 川目裕, 川目裕, 長神風二, 鈴木吉也, 鈴木洋一, 鈴木洋一 …

日本人類遺伝学会大会プログラム・抄録集, 65th (CD-ROM), 2020
ゲノムコホート調査参加者に対するゲノム薬理学(PGx)遺伝情報の返却(回付)-PGxの知識・理解に関する調査票解析

大根田絹子, 布施昇男, 川目裕, 川目裕, 長神風二, 鈴木吉也, 鈴木洋一, 鈴木洋一, 佐藤政文, 櫻井美佳 …

日本人類遺伝学会大会プログラム・抄録集, 65th (CD-ROM), 2020
AMEDにおけるゲノム医療実現に向けた新たなアプローチ -データシェアリングポリシーの策定とその舞台裏-

三成寿作, 加藤治, 櫻井美佳, 齋藤あき

遺伝子医学MOOK 33号, Apr, 2018
Tohoku Medical Megabank Project and the prospects of genomic medicine

7(2) 115-120, Feb, 2018
細胞接着分子CADM1複合体の動態解明―指数関数あてはめを用いたFRAPデータの解析

伊東剛, 櫻井(八下田, 美佳, 村上善則

35(5), Mar, 2017
東北メディカル・メガバンク計画とゲノム研究の展望

櫻井美佳, 清元秀泰

腎臓内科・泌尿器科, 5(1) 87-93, Jan, 2017
「遺伝の仕組み」と「多様性」を学ぶための小児を対象とした遺伝教育ツール開発の取り組み

小林朋子, 小林朋子, 菅原美智子, 石原利乃, 本郷一夫, 相澤弥生, 山口由美, 齋藤さかえ, 田中由佳里, 栗木美穂 …

日本人類遺伝学会大会プログラム・抄録集, 62nd 324, 2017
肺腺がん細胞の実験的転移系を用いた転移関連分子の同定と機能解析

熊谷友紀, 伊東剛, 永田政義, 川合剛人, 丸山智子, 櫻井美佳, 八下田, 後藤明輝, 松原大祐, 村上善則

日本癌学会総会記事, 74回 J-1269, Oct, 2015
Analysis of the role of CADM1 in suppression of lung cancer using Cadm1-deficient mice

Takeshi Ito, Masayoshi Nagata, Taketo Kawai, Mika Sakurai-Yageta, Akihiko Ito, Akiteru Goto, Daisuke Matsubara, Yoshinori Murakami

CANCER RESEARCH, 75, Aug, 2015
Trans-Homophilic Interaction of CADM1 Activates PI3K by Forming a Complex with MAGuK-Family Proteins MPP3 and Dlg (vol 9, e82894, 2014)

S. Murakami, M. Sakurai-Yageta, T. Maruyama, Y. Murakami

PLOS ONE, 9(9), Sep, 2014
遺伝子欠損マウスを用いたCADM1の肺腫瘍抑制における役割の解明(Analysis of the role of CADM1 in suppression of lung cancer using Cadm1-deficient mice)

伊東剛, 永田政義, 川合剛人, 丸山智子, 櫻井美佳, 八下田, 伊藤彰彦, 後藤明輝, 松原大祐, 村上善則

日本癌学会総会記事, 73回 P-2021, Sep, 2014
肺腺がん細胞株の実験的肺転移における遺伝子発現変動を指標として抽出される転移関連因子の探索(Screening of metastasis-related genes by microarray analysis of lung cancer cells using experimental lung metastasis)

熊谷友紀, 伊東剛, 永田政義, 川合剛人, 丸山智子, 櫻井美佳, 八下田, 後藤明輝, 松原大祐, 村上善則

日本癌学会総会記事, 73回 P-3133, Sep, 2014
EXPRESSION OF A SPLICING VARIANT OF THE CADM1 SPECIFIC TO SMALL CELL LUNG CANCER

Shinji Kikuchi, Miwako Iwai, Mika Sakurai-Yageta, Yumi Tsuboi, Takeshi Ito, Tomoko Maruyama, Hitoshi Tsuda, Yae Kanai, Yukinobu Goto, Mitsuaki Sakai …

JOURNAL OF THORACIC ONCOLOGY, 8 S754-S754, Nov, 2013
遺伝子欠損マウスを用いたCADM1の肺腫瘍抑制における役割の解明(Analysis of the role of CADM1 in suppression of lung cancer development using Cadm1-deficient mice)

伊東剛, 永田政義, 川合剛人, 丸山智子, 櫻井美佳, 八下田, 伊藤彰彦, 後藤明輝, 松原大祐, 村上善則

日本癌学会総会記事, 71回 246-246, Aug, 2012
肺腺がんのEGFR-TK阻害剤に対する耐性獲得における細胞接着分子CADM1の役割(Possible involvement of a cell adhesion molecule, CADM1 in acquired resistance of lung adenocarcinoma to EGFR-TKIs)

桑野秀規, 岩井美和子, 川合剛人, 伊東剛, 桜井美佳, 八下田, 後藤明輝, 小泉史明, 中島淳, 田村研治 …

日本癌学会総会記事, 71回 442-442, Aug, 2012
がん研究への病理学の新しい関わり方分子病理学的解析が示す細胞接着分子CADM1のヒト肺癌における抑制、促進両面の役割(Concurrent integration of pathology and cancer research Dual roles of a cell adhesion molecule, CADM1, in lung oncogenesis based on the molecular pathological analyses)

村上善則, 桜井美佳, 伊東剛, 桑野秀規, 松原大祐, 後藤明輝

日本癌学会総会記事, 71回 450-450, Aug, 2012
肺腺がん細胞株の実験的肺転移における遺伝子発現変動を指標として抽出される転移関連因子の探索(Screening of metastasis-related genes by microarray analysis of lung cancer cells using experimental lung metastasis)

熊谷友紀, 伊東剛, 永田政義, 川合剛人, 丸山智子, 櫻井美佳, 八下田, 後藤明輝, 村上善則

日本癌学会総会記事, 71回 487-487, Aug, 2012
肝吸虫関連および非関連肝内胆管癌におけるCADM1の発現日本及びタイ症例の比較研究(Loss of CADM1 expression in cholangiocarcinoma related and unrelated to liver fluke infection)

後藤明輝, 櫻井美佳, 八下田, Pairojkul Chawalit, Yongvanit Puangrat, 柴原純二, 深山正久, 村上善則

日本癌学会総会記事, 70回 303-303, Sep, 2011
乳がんの進展、再発に関わる細胞接着分子CADM1、並びに新規分子標的の解析(Identification of molecular targets involved in the progression and recurrence of breast cancer)

村上善則, 高橋由佳, 岩井美和子, 荒川敦, 伊東剛, 櫻井美佳, 八下田, 伊藤彰彦, 後藤明輝, 伊東紀子 …

日本癌学会総会記事, 70回 215-215, Sep, 2011
miR-375およびmiR-214/199aによるCADM1の発現抑制とそのがん化への関与(Suppression of CADM1 expression by miR-375 and miR-214/199a and its role in tumorigenesis)

石村恵, 櫻井美佳, 八下田, 後藤明輝, 村上善則

日本癌学会総会記事, 70回 269-269, Sep, 2011

Professional Memberships

Research Projects

A molecular-epidemiological study on risk factors of gallbladder cancer

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Genetic and molecular epidemiology study of GWAS-identified pancreatic cancer-associated GP2 gene

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Interdisciplinary fusion research for precision medicine in heart failure patients with preserved ejection fraction

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2024
ビオチン代謝によるアレルギー性気道炎症の制御メカニズムの解明

科研費補助金基盤研究(C), 文部科学省, Apr, 2016 - Mar, 2019

櫻井美佳
Analysis of cell-context dependent features of adhesion molecules for cancer diagnosis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

MURAKAMI Yoshinori
生体イメージングを用いた細胞接着分子CADM1のがん化における役割の解析

科研費補助金若手研究(B), 文部科学省, Apr, 2012 - Mar, 2015

櫻井美佳
細胞接着分子群の解析に基づく、がんの個性診断法の開発

科研費補助金基盤研究(B), 文部科学省, Apr, 2010 - Mar, 2013

村上善則
Ig様接着分子CADM1による細胞間接着と浸潤における動態と下流分子経路の解明

科研費補助金若手研究(B), 文部科学省, Apr, 2009 - Mar, 2012

櫻井美佳
がん関連遺伝子の構造、発現、機能解析によるがんの分子診断と病態の解明

科研費補助金特定領域研究, 文部科学省, Apr, 2005 - Mar, 2010

村上善則

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