論文

査読有り 国際誌
2018年12月1日

High Order Formation and Evolution of Hornerin in Primates.

Genome biology and evolution
  • Vanessa Romero
  • ,
  • Hirofumi Nakaoka
  • ,
  • Kazuyoshi Hosomichi
  • ,
  • Ituro Inoue

10
12
開始ページ
3167
終了ページ
3175
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/gbe/evy208

Genomic duplication or loss can accelerate evolution because the number of repeats could affect molecular pathways and phenotypes. We have previously reported that the repeated region of filaggrin (FLG), a crucial component of the outer layers of mammalian skin, had high levels of nucleotide diversity with species-specific divergence and expansion and that it evolved under the birth-and-death model. We focused on hornerin (HRNR), a member of the same gene family that harbor similar tandem repeats as FLG, and examined the formation process of repeated regions and the evolutional model that best fit the HRNR repeated region in the crab-eating macaque (Macaca fascicularis), orangutan (Pongo abelii), gorilla (Gorilla gorilla), and chimpanzee (Pan troglodytes) and compared them with the human (Homo sapiens) sequence. Paar et al. (2011) and Takaishi et al. (2005) have different theories as to the formation of the repeated region of HRNR; both groups share the longest repeat length of 1,404 bp (quartic or longest unit), but they differed in the process. We identified the formation described by Paar et al. {[("39 bp (primary) × 9" × 2 (secondary)) × 2 (tertiary)] × 5 (quartic)} to be conserved in all species except the crab-eating macaque. We detected high nucleotide diversities between the longest repeats, which fits the birth-and-death model. We concluded that the high order repeat formation of HRNR was conserved in primates except the crab-eating macaque. As previously identified in FLG, the longest repeats have high levels of nucleotide diversity, which could contribute to phenotypic differences between closely related species.

リンク情報
DOI
https://doi.org/10.1093/gbe/evy208
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30256937
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280949
ID情報
  • DOI : 10.1093/gbe/evy208
  • PubMed ID : 30256937
  • PubMed Central 記事ID : PMC6280949

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