2009年10月
Adiponectin Deficiency Increases Allergic Airway Inflammation and Pulmonary Vascular Remodeling
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
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- 巻
- 41
- 号
- 4
- 開始ページ
- 397
- 終了ページ
- 406
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1165/rcmb.2008-0415OC
- 出版者・発行元
- AMER THORACIC SOC
Obesity is associated with an increased incidence and severity of asthma, as well as other lung disorders, such as pulmonary hypertension. Adiponectin (APN), an antiinflammatory adipocytokine, circulates at lower levels in the obese, which is thought to contribute to obesity-related inflammatory diseases. We sought to determine the effects of APN deficiency in a murine model of chronic asthma. Allergic airway inflammation was induced in APN-deficient mice (APN(-/-)) using sensitization without adjuvant followed by airway challenge with ovalbumin. The mice were then analyzed for changes in inflammation and lung remodeling. APN(-/-) mice in this model develop increased allergic airway inflammation compared with wildtype mice, with greater accumulation of eosinophils and monocytes in the airways associated with elevated lung chemokine levels. Surprisingly, APN-/- mice developed severe pulmonary arterial muscularization and pulmonary arterial hypertension in this model, whereas wild-type mice had only mild vascular remodeling and comparatively less pulmonary arterial hypertension. Our findings demonstrate that APN modulates allergic inflammation and pulmonary vascular remodeling in a model of chronic asthma. These data provide a possible mechanism for the association between obesity and asthma, and suggest a potential novel link between obesity, inflammatory lung disease, and pulmonary hypertension.
- リンク情報
- ID情報
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- DOI : 10.1165/rcmb.2008-0415OC
- ISSN : 1044-1549
- PubMed ID : 19168697
- Web of Science ID : WOS:000270191200003