論文

査読有り
2014年5月

Retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy for stage III and IV oral cancer: Analysis of therapeutic results in 112 cases

RADIOTHERAPY AND ONCOLOGY
  • Kenji Mitsudo
  • ,
  • Toshiyuki Koizumi
  • ,
  • Masaki Iida
  • ,
  • Toshinori Iwai
  • ,
  • Hideyuki Nakashima
  • ,
  • Senri Oguri
  • ,
  • Mitomu Kioi
  • ,
  • Makoto Hirota
  • ,
  • Izumi Koike
  • ,
  • Masaharu Hata
  • ,
  • Iwai Tohnai

111
2
開始ページ
306
終了ページ
310
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.radonc.2014.03.005
出版者・発行元
ELSEVIER IRELAND LTD

Purpose: To evaluate the therapeutic results and rate of organ preservation in patients with stage III or IV oral cancer treated with retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy.
Materials and methods: One hundred and twelve patients with stage III and IV oral squamous cell carcinoma underwent intra-arterial chemoradiotherapy. Catheterization from the superficial temporal and occipital arteries was performed. Treatment consisted of superselective intra-arterial chemotherapy (docetaxel, total 60 mg/m(2), cisplatin, total 150 mg/m(2)) and daily concurrent radiotherapy (total of 60 Gy) for 6 weeks.
Results: The median follow-up for all patients was 46.2 months (range, 10-76 months). After intra-arterial chemoradiotherapy, primary site complete response was achieved in 98 (87.5%) of 112 cases. Five-year survival and local control rates were 71.3% and 79.3%, respectively. Grade 3 or 4 toxicities included mucositis in 92.0%, neutropenia in 30.4%, dermatitis in 28.6%, anemia in 26.8%, and thrombocytopenia in 7.1% of patients. Grade 3 toxicities included dysphagia in 72.3%, nausea/vomiting in 21.4%, fever in 8.0%, and renal failure in 0.9% of patients.
Conclusion: Retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy for stage III and IV oral cancer provided good overall survival and local control. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Web of Science ® 被引用回数 : 30

リンク情報
DOI
https://doi.org/10.1016/j.radonc.2014.03.005
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000339150100023&DestApp=WOS_CPL

エクスポート
BibTeX RIS