論文

査読有り
2014年2月

Radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy for gingival carcinoma

STRAHLENTHERAPIE UND ONKOLOGIE
  • Y. Mukai
  • ,
  • M. Hata
  • ,
  • K. Mitsudo
  • ,
  • I. Koike
  • ,
  • T. Koizumi
  • ,
  • S. Oguri
  • ,
  • M. Kioi
  • ,
  • M. Omura
  • ,
  • I. Tohnai
  • ,
  • T. Inoue

190
2
開始ページ
181
終了ページ
185
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00066-013-0468-1
出版者・発行元
URBAN & VOGEL

Purpose. The aim of this study was to review the efficacy and toxicity of radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy in the treatment of gingival carcinoma.
Methods and materials. In all, 34 patients (21 men and 13 women) with squamous cell carcinoma of the gingiva underwent radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy. Treatment consisted of daily external irradiation and concurrent retrograde superselective intra-arterial infusion with cisplatin and docetaxel. A median total dose of 60 Gy in 30 fractions was delivered to tumors.
Results. Of the 34 patients, 29 (85 %) achieved a complete response (CR) and 5 had residual tumors. Of the 29 patients with a CR, 2 had local recurrences and 1 had distant metastasis 1-15 months after treatment. Twenty-six of the 36 patients had survived at a median follow-up time of 36 months (range 12-79 months); 4 died of cancer and 4 died of non-cancer-related causes. At both 3 and 5 years after treatment, the overall survival rates were 79 % and the cause-specific survival rates were 85 %. Osteoradionecrosis of the mandibular bone only developed in 1 patient after treatment.
Conclusion. Radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy was effective and safe in the treatment of gingival carcinoma. This treatment may be a promising curative and organ-preserving treatment option for gingival carcinoma.

Web of Science ® 被引用回数 : 5

リンク情報
DOI
https://doi.org/10.1007/s00066-013-0468-1
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000330623000006&DestApp=WOS_CPL

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