論文

査読有り
2014年9月

Solitary myofibroma of the mandible: an immunohistochemical and ultrastructural study with a review of the literature

MEDICAL MOLECULAR MORPHOLOGY
  • Takafumi Satomi
  • ,
  • Michihide Kohno
  • ,
  • Ai Enomoto
  • ,
  • Harutsugu Abukawa
  • ,
  • Ko Fujikawa
  • ,
  • Toshiyuki Koizumi
  • ,
  • Daichi Chikazu
  • ,
  • Jun Matsubayashi
  • ,
  • Toshitaka Nagao

47
3
開始ページ
176
終了ページ
183
記述言語
英語
掲載種別
DOI
10.1007/s00795-013-0062-8
出版者・発行元
SPRINGER JAPAN KK

A solitary myofibroma (MF) is an unusual spindle cell neoplasm that usually arises in the soft tissue, skin, or bone of the head and neck region in infancy. We report an extremely rare case of MF of the mandible in an 18-year-old Japanese woman together with the conventional histologic, immunohistochemical, and electron microscopic findings. The tumor was well circumscribed and composed of fibroblast-like or myofibroblast-like spindle cells. On immunohistochemical evaluation the tumor cells were positive for vimentin, alpha-smooth muscle actin, HHF-35, and calponin, but negative for neurogenic antigens and markers for vascular endothelial cells. The Ki-67 labeling index was 10 % and the p53 labeling index was 10 %. Ultrastructural examination revealed smooth muscle cell differentiation. The patient was treated by surgical resection and underwent follow-up without any signs of recurrence. MF presents a wide range of differential diagnosis, including benign and malignant neoplasms. Therefore, accurate diagnosis may avoid an unnecessarily aggressive therapy.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1007/s00795-013-0062-8
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000341921900008&DestApp=WOS_CPL

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