2021年6月25日
Lipoprotein Particle Profiles Compared With Standard Lipids in the Association With Subclinical Aortic Valve Calcification in Apparently Healthy Japanese Men(和訳中)
Circulation Journal
- 巻
- 85
- 号
- 7
- 開始ページ
- 1076
- 終了ページ
- 1082
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1253/circj.CJ-20-1090
- 出版者・発行元
- (一社)日本循環器学会
BACKGROUND: Risk factors for atherosclerotic disease including dyslipidemia have been shown to be associated with aortic valve calcification (AVC). Nuclear magnetic resonance (NMR)-measured lipoprotein particles, low-density and high-density lipoprotein particles (LDL-p, HDL-p) in particular, have emerged as novel markers of atherosclerotic disease; however, whether NMR-measured particles are associated with AVC remains to be determined. This study aimed to examine the association between NMR-based lipoprotein particle measurements and standard lipids with AVC. The primary variables of interest were LDL-p (nmol/L), HDL-p (μmol/L), LDL-cholesterol, and HDL-cholesterol (both in mg/dL).Methods and Results:A community-based random sample of Japanese men aged 40-79 years examined in 2006-2008, in Shiga, Japan was studied. Presence of AVC was defined as an Agatston score >0. Lipoprotein particles were measured using NMR spectroscopy. In the main analysis, multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for the prevalence of AVC across the higher quartiles of lipids in reference to the lowest ones were obtained. Of 874 participants analyzed, 153 men had AVC. Multivariable-adjusted ORs of prevalent AVC for the highest vs. the lowest quartile were significantly elevated for LDL-p (OR, 2.20; 95% CI: 1.23-3.93) and LDL-cholesterol (OR, 2.16; 95% CI: 1.23-3.78). In contrast, neither HDL-p nor HDL-cholesterol was associated with AVC. CONCLUSIONS: The association of prevalent AVC with NMR-based LDL-p was comparable to that with LDL-cholesterol.
- リンク情報
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- DOI
- https://doi.org/10.1253/circj.CJ-20-1090
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/34092755
- URL
- https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J04756&link_issn=&doc_id=20210702370016&doc_link_id=34092755&url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F34092755&type=PubMed&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00001_1.gif
- URL
- https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J04756&link_issn=&doc_id=20210702370016&doc_link_id=10.1253%2Fcircj.CJ-20-1090&url=https%3A%2F%2Fdoi.org%2F10.1253%2Fcircj.CJ-20-1090&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif
- URL
- https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J04756&link_issn=&doc_id=20210702370016&doc_link_id=http%3A%2F%2Fhdl.handle.net%2F10422%2F00013034&url=http%3A%2F%2Fhdl.handle.net%2F10422%2F00013034&type=%8E%A0%89%EA%88%E3%89%C8%91%E5%8Aw%81F%8E%A0%89%EA%88%E3%89%C8%91%E5%8Aw%8B%40%8A%D6%83%8A%83%7C%83W%83g%83%8A%82%D1%82%ED%8C%C9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80165_3.gif
- ID情報
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- DOI : 10.1253/circj.CJ-20-1090
- ISSN : 1346-9843
- eISSN : 1347-4820
- 医中誌Web ID : V702370016
- PubMed ID : 34092755