2014年2月
Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases
JOURNAL OF HUMAN GENETICS
- 巻
- 59
- 号
- 2
- 開始ページ
- 107
- 終了ページ
- 109
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/jhg.2013.129
- 出版者・発行元
- NATURE PUBLISHING GROUP
Although the association between CYP3A5 polymorphism and blood concentration of tacrolimus (TAC) in patients with solid organ transplantation was established, whether the association is also true in patients with connective tissue disease (CTD) who usually receive small amount of TAC is uncertain. Here, we performed a quantitative linear regression analysis to address the association between CYP3A5 and blood TAC concentration in patients with CTD. A total of 72 patients with CTD were recruited in the current study and genotyped for rs776746 in CYP3A5, which showed strong association with TAC concentration in patients with solid organ transplantation. The blood trough concentration of TAC after taking 3mg per day was retrospectively obtained for each patient. As a result, allele A of rs776746 showed a significant association with a decreasing blood concentration of TAC (P = 0.0038). Those who are carrying at least one copy of the A allele displayed decreased mean concentration of TAC by 31.0% compared with subjects with GG genotype. Rs776746 is associated with concentrations of TAC in patients with CTD.
- リンク情報
- ID情報
-
- DOI : 10.1038/jhg.2013.129
- ISSN : 1434-5161
- eISSN : 1435-232X
- PubMed ID : 24352002
- Web of Science ID : WOS:000332019700008