論文

査読有り
1993年8月

CLONING AND SEQUENCE-ANALYSIS OF MOUSE CDNAS ENCODING PREPROTACHYKININ-A AND PREPROTACHYKININ-B

BIOMEDICAL RESEARCH-TOKYO
  • K KAKO
  • ,
  • E MUNEKATA
  • ,
  • M HOSAKA
  • ,
  • K MURAKAMI
  • ,
  • K NAKAYAMA

14
4
開始ページ
253
終了ページ
259
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2220/biomedres.14.253
出版者・発行元
BIOMED RES FOUND

We describe here the isolation and characterization of cDNAs from mouse brain coding for the precursor of substance P and neurokinin A, preprotachykinin A (PPT-A), and for the precursor of neurokinin B, preprotachykinin B (PPT-B). Two types of mouse PPT-A cDNA encoding beta-PPT-A and gamma-PPT-A were obtained. The latter lacked the coding region corresponding to the exon 4 of the PPT-A gene, as is observed in other species. Mouse beta-PPT-A deduced from the cDNA sequence consisted of 130 amino acids, and showed extensive homology to rat, human, and bovine beta-PPT-As, with 99%, 95%, 92% amino acid identities, respectively. The substance P and neurokinin A sequences were the same among these species. Mouse PPT-B deduced from the cDNA sequence consisted of 116 amino acids, and shows homology to rat and bovine PPT-Bs, with 93% and 78% amino acid identities, respectively; thus the homology of PPT-B among these species is less prominent than that of PPT-A. The neurokinin B sequence was the same among these species.

リンク情報
DOI
https://doi.org/10.2220/biomedres.14.253
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1993LV32300002&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-0027260480&partnerID=MN8TOARS
URL
http://orcid.org/0000-0001-7701-7183
ID情報
  • DOI : 10.2220/biomedres.14.253
  • ISSN : 0388-6107
  • ORCIDのPut Code : 44277941
  • SCOPUS ID : 0027260480
  • Web of Science ID : WOS:A1993LV32300002

エクスポート
BibTeX RIS