1993年8月
CLONING AND SEQUENCE-ANALYSIS OF MOUSE CDNAS ENCODING PREPROTACHYKININ-A AND PREPROTACHYKININ-B
BIOMEDICAL RESEARCH-TOKYO
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- 巻
- 14
- 号
- 4
- 開始ページ
- 253
- 終了ページ
- 259
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2220/biomedres.14.253
- 出版者・発行元
- BIOMED RES FOUND
We describe here the isolation and characterization of cDNAs from mouse brain coding for the precursor of substance P and neurokinin A, preprotachykinin A (PPT-A), and for the precursor of neurokinin B, preprotachykinin B (PPT-B). Two types of mouse PPT-A cDNA encoding beta-PPT-A and gamma-PPT-A were obtained. The latter lacked the coding region corresponding to the exon 4 of the PPT-A gene, as is observed in other species. Mouse beta-PPT-A deduced from the cDNA sequence consisted of 130 amino acids, and showed extensive homology to rat, human, and bovine beta-PPT-As, with 99%, 95%, 92% amino acid identities, respectively. The substance P and neurokinin A sequences were the same among these species. Mouse PPT-B deduced from the cDNA sequence consisted of 116 amino acids, and shows homology to rat and bovine PPT-Bs, with 93% and 78% amino acid identities, respectively; thus the homology of PPT-B among these species is less prominent than that of PPT-A. The neurokinin B sequence was the same among these species.
- リンク情報
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- DOI
- https://doi.org/10.2220/biomedres.14.253
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1993LV32300002&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-0027260480&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0001-7701-7183
- ID情報
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- DOI : 10.2220/biomedres.14.253
- ISSN : 0388-6107
- ORCIDのPut Code : 44277941
- SCOPUS ID : 0027260480
- Web of Science ID : WOS:A1993LV32300002