論文

査読有り
2004年6月

STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells

ONCOGENE
  • N Kanda
  • H Seno
  • Y Konda
  • H Marusawa
  • M Kanai
  • T Nakajima
  • T Kawashima
  • A Nanakin
  • T Sawabu
  • Y Uenoyama
  • A Sekikawa
  • M Kawada
  • K Suzuki
  • T Kayahara
  • H Fukui
  • M Sawada
  • T Chiba
  • 全て表示

23
28
開始ページ
4921
終了ページ
4929
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/sj.onc.1207606
出版者・発行元
NATURE PUBLISHING GROUP

Signal transduction and activator of transcription 3(STAT3) signaling is constitutively activated in various tumors, and is involved in cell survival and proliferation during oncogenesis. There are few reports, however, on the role of STAT3 signaling in gastric cancer. The aim of the present study was to clarify the role of STAT3 signaling in apoptosis and cellular proliferation in gastric cancer. Here we reported that STAT3 was constitutively activated in various human gastric cancer cells and its inhibition by ectopic dominant-negative STAT3 or Janus kinase inhibitor, tyrphostin AG490, induced apoptosis. Furthermore, STAT3 inhibition markedly decreased survivin expression, and forced expression of survivin rescued AGS cells from apoptosis induced by STAT3 inhibition. Although some reports demonstrated that the PI3K/Akt pathway regulates survivin expression, inhibition of the PI3K/Akt pathway did not affect survivin expression in AGS and MKN1 cells. Finally, activated form of STAT3, Tyr-705 phospho-stat3, was found in the nucleus of cancer cells in 11 of 40 (27.5%) human gastric cancer specimens. These findings suggest that constitutively activated STAT3 signaling supports gastric cancer cell survival in association with survivin expression.

リンク情報
DOI
https://doi.org/10.1038/sj.onc.1207606
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/15077160
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000222104200013&DestApp=WOS_CPL
ID情報
  • DOI : 10.1038/sj.onc.1207606
  • ISSN : 0950-9232
  • PubMed ID : 15077160
  • Web of Science ID : WOS:000222104200013

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