論文

査読有り
2005年6月

Hepatitis B virus infection in lymphatic tissues in inactive hepatitis B carriers

JOURNAL OF HEPATOLOGY
  • M Umeda
  • ,
  • H Marusawa
  • ,
  • H Seno
  • ,
  • A Katsurada
  • ,
  • M Nabeshima
  • ,
  • H Egawa
  • ,
  • S Uemoto
  • ,
  • Y Inomata
  • ,
  • K Tanaka
  • ,
  • T Chiba

42
6
開始ページ
806
終了ページ
812
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jhep.2005.01.016
出版者・発行元
ELSEVIER SCIENCE BV

Background/Aims: Hepatitis B virus (HBV) infection in extrahepatic tissues is controversial. To clarify whether episomal HBV can infect nonhepatic tissues, we investigated the molecular forms of HBV in the lymphatic cells of inactive HBV carriers who lacked viremia, thus avoiding contamination with HBV genomes originating from the viral particles present in the serum.
Methods: We assessed HBV genome, replicative forms, and viral integrants in the liver, serum, peripheral blood mononuclear cells (PBMC), and lymph nodes of 21 inactive HBV carriers who tested positive for antibodies against the HBV core antigen (anti-HBc).
Results: Of the 21 anti-HBc positive individuals, HBV-DNA was detected in liver samples of 15 (71.4%), in the lymph nodes of 11 (52.4%), and in PBMC of three (14.3%). However, none of the detected HBV genomes from lymphatic tissues included the replicative forms of HBV. In one case, integrated HBV was present in the lymphatic tissues and the host-viral junction was present in the intronic sequences of chromosome 17.
Conclusions: These data suggest that human lymphatic tissues cannot support viral replication in anti-HBc positive inactive HBV carriers, while retaining the viral genome as an integrated form. (C) 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.jhep.2005.01.016
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/15885350
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000229523400005&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.jhep.2005.01.016
  • ISSN : 0168-8278
  • PubMed ID : 15885350
  • Web of Science ID : WOS:000229523400005

エクスポート
BibTeX RIS