論文

査読有り
2012年3月

The role of Hes genes in intestinal development, homeostasis and tumor formation

DEVELOPMENT
  • Taro Ueo
  • ,
  • Itaru Imayoshi
  • ,
  • Taeko Kobayashi
  • ,
  • Toshiyuki Ohtsuka
  • ,
  • Hiroshi Seno
  • ,
  • Hiroshi Nakase
  • ,
  • Tsutomu Chiba
  • ,
  • Ryoichiro Kageyama

139
6
開始ページ
1071
終了ページ
1082
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1242/dev.069070
出版者・発行元
COMPANY OF BIOLOGISTS LTD

Notch signaling regulates intestinal development, homeostasis and tumorigenesis, but its precise downstream mechanism remains largely unknown. Here we found that inactivation of the Notch effectors Hes1, Hes3 and Hes5, but not Hes1 alone, led to reduced cell proliferation, increased secretory cell formation and altered intestinal structures in adult mice. However, in Apc mutation-induced intestinal tumors, inactivation of Hes1 alone was sufficient for reducing tumor cell proliferation and inducing differentiation of tumor cells into all types of intestinal epithelial cells, but without affecting the homeostasis of normal crypts owing to genetic redundancy. These results indicated that Hes genes cooperatively regulate intestinal development and homeostasis and raised the possibility that Hes1 is a promising target to induce the differentiation of tumor cells.

リンク情報
DOI
https://doi.org/10.1242/dev.069070
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22318232
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000300640700003&DestApp=WOS_CPL
ID情報
  • DOI : 10.1242/dev.069070
  • ISSN : 0950-1991
  • PubMed ID : 22318232
  • Web of Science ID : WOS:000300640700003

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