論文

査読有り
2012年5月

The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs

BIOLOGY OPEN
  • Mako Yamamoto
  • Tomoko Matsuzaki
  • Rei Takahashi
  • Eijiro Adachi
  • Yasuhiro Maeda
  • Sachiyo Yamaguchi
  • Hitoshi Kitayama
  • Michiko Echizenya
  • Yoko Morioka
  • David B. Alexander
  • Takeshi Yagi
  • Shigeyoshi Itohara
  • Takashi Nakamura
  • Haruhiko Akiyama
  • Makoto Noda
  • 全て表示

1
5
開始ページ
458
終了ページ
466
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1242/bio.2012638
出版者・発行元
COMPANY OF BIOLOGISTS LTD

The membrane-anchored metalloproteinase-regulator RECK has been characterized as a tumor suppressor. Here we report that mice with reduced Reck-expression show limb abnormalities including right-dominant, forelimb-specific defects in postaxial skeletal elements. The forelimb buds of low-Reck mutants have an altered dorsal ectoderm with reduced Wnt7a and Igf2 expression, and hypotrophy in two signaling centers (i.e., ZPA and AER) that are essential for limb outgrowth and patterning. Reck is abundantly expressed in the anterior mesenchyme in normal limb buds; mesenchymespecific Reck inactivation recapitulates the low-Reck phenotype; and some teratogens downregulate Reck in mesenchymal cells. Our findings illustrate a role for Reck in the mesenchymalepithelial interactions essential for mammalian development. (C) 2012. Published by The Company of Biologists Ltd.

リンク情報
DOI
https://doi.org/10.1242/bio.2012638
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000209205000006&DestApp=WOS_CPL
ID情報
  • DOI : 10.1242/bio.2012638
  • ISSN : 2046-6390
  • Web of Science ID : WOS:000209205000006

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