2012年5月
The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs
BIOLOGY OPEN
- 巻
- 1
- 号
- 5
- 開始ページ
- 458
- 終了ページ
- 466
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1242/bio.2012638
- 出版者・発行元
- COMPANY OF BIOLOGISTS LTD
The membrane-anchored metalloproteinase-regulator RECK has been characterized as a tumor suppressor. Here we report that mice with reduced Reck-expression show limb abnormalities including right-dominant, forelimb-specific defects in postaxial skeletal elements. The forelimb buds of low-Reck mutants have an altered dorsal ectoderm with reduced Wnt7a and Igf2 expression, and hypotrophy in two signaling centers (i.e., ZPA and AER) that are essential for limb outgrowth and patterning. Reck is abundantly expressed in the anterior mesenchyme in normal limb buds; mesenchymespecific Reck inactivation recapitulates the low-Reck phenotype; and some teratogens downregulate Reck in mesenchymal cells. Our findings illustrate a role for Reck in the mesenchymalepithelial interactions essential for mammalian development. (C) 2012. Published by The Company of Biologists Ltd.
- リンク情報
- ID情報
-
- DOI : 10.1242/bio.2012638
- ISSN : 2046-6390
- Web of Science ID : WOS:000209205000006