2017年5月
Higher breast cancer conspicuity on dbPET compared to WB-PET/CT
EUROPEAN JOURNAL OF RADIOLOGY
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- 巻
- 90
- 号
- 開始ページ
- 138
- 終了ページ
- 145
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.ejrad.2017.02.046
- 出版者・発行元
- ELSEVIER IRELAND LTD
Objectives: The purpose of this study was to evaluate lesion detectability of a dedicated breast positron-emission tomography (dbPET) scanner for breast cancers with an updated reconstruction mode, comparing it to whole-body positron-emission tomography/computed tomography (WB-PET/CT).
Materials and methods: A total of 179 histologically-proven breast cancer lesions in 150 females who underwent both WB-PET/CT and dbPET with F-18-fluorodeoxyglucose were retrospectively analyzed. The patient/breast/lesion-based sensitivities based on visual analysis were compared between dbPET and WB-PET/CT. For lesions visible on both PET images, SUVmax values of the tumors were measured, and tumor-to-background ratios (T/B ratios) of SUVmax were compared between the two scans. Subgroup analyses according to clinical tumor stage, histopathology and histological grade were also performed.
Results: Patient/breast/lesion-based sensitivities were 95%, 95%, and 92%, respectively, for dbPET, and 95%, 94%, and 88%, respectively, for WB-PET/CT. Mean +/- standard deviation SUVmax values of FDG-avid tumors were 13.0 +/- 9.7 on dbPET and 6.4 +/- 4.8 on WB-PET. T/B ratios were also significantly higher in dbPET than in WB-PET/CT (8.1 +/- 7.1 vs. 5.1 +/- 4.5). In the subgroup analysis, no significant differences in sensitivities between dbPET and WB-PET/CT were found. However, T/B ratios of dbPET were significantly higher than those of WB-PET/CT in cT1c, cT2, cT3, invasive cancer, invasive carcinoma of no special type, mucinous carcinoma and Grades 1-3.
Conclusion: No significant differences in sensitivities were identified between dbPET using an updated reconstruction mode and WB-PET/CT; however, T/B ratios of dbPET were significantly higher than those of WB-PET/CT, indicating higher tumor conspicuity on dbPET. (C) 2017 Elsevier B.V. All rights reserved.
Materials and methods: A total of 179 histologically-proven breast cancer lesions in 150 females who underwent both WB-PET/CT and dbPET with F-18-fluorodeoxyglucose were retrospectively analyzed. The patient/breast/lesion-based sensitivities based on visual analysis were compared between dbPET and WB-PET/CT. For lesions visible on both PET images, SUVmax values of the tumors were measured, and tumor-to-background ratios (T/B ratios) of SUVmax were compared between the two scans. Subgroup analyses according to clinical tumor stage, histopathology and histological grade were also performed.
Results: Patient/breast/lesion-based sensitivities were 95%, 95%, and 92%, respectively, for dbPET, and 95%, 94%, and 88%, respectively, for WB-PET/CT. Mean +/- standard deviation SUVmax values of FDG-avid tumors were 13.0 +/- 9.7 on dbPET and 6.4 +/- 4.8 on WB-PET. T/B ratios were also significantly higher in dbPET than in WB-PET/CT (8.1 +/- 7.1 vs. 5.1 +/- 4.5). In the subgroup analysis, no significant differences in sensitivities between dbPET and WB-PET/CT were found. However, T/B ratios of dbPET were significantly higher than those of WB-PET/CT in cT1c, cT2, cT3, invasive cancer, invasive carcinoma of no special type, mucinous carcinoma and Grades 1-3.
Conclusion: No significant differences in sensitivities were identified between dbPET using an updated reconstruction mode and WB-PET/CT; however, T/B ratios of dbPET were significantly higher than those of WB-PET/CT, indicating higher tumor conspicuity on dbPET. (C) 2017 Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.ejrad.2017.02.046
- ISSN : 0720-048X
- eISSN : 1872-7727
- PubMed ID : 28583624
- Web of Science ID : WOS:000404560300017