2010年7月
Prevalence of positive FDG-PET findings in patients with high CEA levels
ANNALS OF NUCLEAR MEDICINE
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- 巻
- 24
- 号
- 6
- 開始ページ
- 433
- 終了ページ
- 439
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s12149-010-0387-5
- 出版者・発行元
- SPRINGER
The purpose of this study was to evaluate the prevalence of positive findings of positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-d-glucose (FDG) in patients with high serum CEA levels.
A total of 303 patients who had undergone an FDG-PET scan in our institution with high serum CEA levels were analyzed. The prevalence of positive PET findings was evaluated with regard to a previous history of malignancy, absolute value of CEA levels, and the time course of CEA levels (an increasing or decreasing pattern, a change divided by time (Delta CEA) and doubling time of CEA).
Of 303 patients, 232 were confirmed to have malignancy, and the patient-based sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of PET were 87, 86, 95, 66, and 86%, respectively. There was no statistically significant difference in positive rates according to the history of previous malignancy. The prevalence of PET-positive cases was higher with an increase in absolute CEA levels, and more than 90% of the patients were positive when CEA levels were more than 20 ng/ml. The Delta CEA was significantly higher and the doubling time was significantly shorter in patients with positive results than those with negative results.
A high value of serum CEA levels was correlated with a higher prevalence of positive PET findings. FDG-PET scans would be justified in patients with high serum CEA levels, regardless of whether there was or was not a previous history of malignancy.
A total of 303 patients who had undergone an FDG-PET scan in our institution with high serum CEA levels were analyzed. The prevalence of positive PET findings was evaluated with regard to a previous history of malignancy, absolute value of CEA levels, and the time course of CEA levels (an increasing or decreasing pattern, a change divided by time (Delta CEA) and doubling time of CEA).
Of 303 patients, 232 were confirmed to have malignancy, and the patient-based sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of PET were 87, 86, 95, 66, and 86%, respectively. There was no statistically significant difference in positive rates according to the history of previous malignancy. The prevalence of PET-positive cases was higher with an increase in absolute CEA levels, and more than 90% of the patients were positive when CEA levels were more than 20 ng/ml. The Delta CEA was significantly higher and the doubling time was significantly shorter in patients with positive results than those with negative results.
A high value of serum CEA levels was correlated with a higher prevalence of positive PET findings. FDG-PET scans would be justified in patients with high serum CEA levels, regardless of whether there was or was not a previous history of malignancy.
- リンク情報
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- DOI
- https://doi.org/10.1007/s12149-010-0387-5
- CiNii Articles
- http://ci.nii.ac.jp/naid/10026596303
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/20544325
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000280064800001&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1007/s12149-010-0387-5
- ISSN : 0914-7187
- CiNii Articles ID : 10026596303
- PubMed ID : 20544325
- Web of Science ID : WOS:000280064800001