2012年4月
Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels
NATURE COMMUNICATIONS
- 巻
- 3
- 号
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/ncomms1786
- 出版者・発行元
- NATURE PUBLISHING GROUP
Tumour recurrence frequently occurs after radiotherapy, but the characteristics, intratumoural localization and post-irradiation behaviour of radioresistant cancer cells remain largely unknown. Here we develop a sophisticated strategy to track the post-irradiation fate of the cells, which exist in perinecrotic regions at the time of radiation. Although the perinecrotic tumour cells are originally hypoxia-inducible factor 1 (HIF-1)-negative, they acquire HIF-1 activity after surviving radiation, which triggers their translocation towards tumour blood vessels. HIF-1 inhibitors suppress the translocation and decrease the incidence of post-irradiation tumour recurrence. For the first time, our data unveil the HIF-1-dependent cellular dynamics during post-irradiation tumour recurrence and provide a rational basis for targeting HIF-1 after radiation therapy.
- リンク情報
-
- DOI
- https://doi.org/10.1038/ncomms1786
- CiNii Articles
- http://ci.nii.ac.jp/naid/120004007582
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/22510688
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000303455200020&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1038/ncomms1786
- ISSN : 2041-1723
- CiNii Articles ID : 120004007582
- PubMed ID : 22510688
- Web of Science ID : WOS:000303455200020