論文

査読有り 招待有り 国際誌
2018年3月

Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge.

Cancer science
  • Sho Koyasu
  • ,
  • Minoru Kobayashi
  • ,
  • Yoko Goto
  • ,
  • Masahiro Hiraoka
  • ,
  • Hiroshi Harada

109
3
開始ページ
560
終了ページ
571
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/cas.13483

Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator of various genes related to cellular adaptive responses to hypoxia. Dysfunctions in the regulatory systems of HIF-1 activity have been implicated in the pathogenesis of various diseases including malignant tumors and, thus, elucidating the molecular mechanisms underlying the activation of HIF-1 is eagerly desired for the development of novel anti-cancer strategies. The importance of oxygen-dependent and ubiquitin-mediated proteolysis of the regulatory subunit of HIF-1 (HIF-1α) was first reported in 1997. Since then, accumulating evidence has shown that HIF-1α may become stable and active even under normoxic conditions; for example, when disease-associated genetic and functional alterations in some genes trigger the aberrant activation of HIF-1 regardless of oxygen conditions. We herein review the last two decades of knowledge, since 1997, on the regulatory mechanisms of HIF-1 activity from conventional oxygen- and proteolysis-dependent mechanisms to up-to-the-minute information on cancer-associated genetic and functional alteration-mediated mechanisms.

リンク情報
DOI
https://doi.org/10.1111/cas.13483
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29285833
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834787
ID情報
  • DOI : 10.1111/cas.13483
  • PubMed ID : 29285833
  • PubMed Central 記事ID : PMC5834787

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