2018年8月
pH-Responsive Cy5 dyes having nucleophilic substituents for molecular imaging
TETRAHEDRON LETTERS
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- 巻
- 59
- 号
- 35
- 開始ページ
- 3317
- 終了ページ
- 3321
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.tetlet.2018.07.044
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
pH-Responsive fluorescent pentamethine cyanine (Cy5) derivatives having nucleophilic substituents were synthesized. Cy5 derivatives 1-O having mercaptopropyl, hydroxypropyl, and aminopropyl groups on an indole nitrogen atom showed pH-dependent equilibria between a fluorescent open-ring structure (1-O) and a non-fluorescent closed-ring structure (1-C) in pH ranges 3-7, 6-7.5, and 8-9, respectively. pH-Responsive dyes 1a-C having a 1,3-thiazinane structure were easily internalized into A549 cells and converted to open-ring structure 1a-O in response to the relatively low pH of acidic compartments in the cells. (C) 2018 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.tetlet.2018.07.044
- ISSN : 0040-4039
- Web of Science ID : WOS:000445299100004