論文

査読有り
2018年8月

pH-Responsive Cy5 dyes having nucleophilic substituents for molecular imaging

TETRAHEDRON LETTERS
  • Masahiro Oe
  • ,
  • Koji Miki
  • ,
  • Huiying Mu
  • ,
  • Hiroshi Harada
  • ,
  • Akiyo Morinibu
  • ,
  • Kouichi Ohe

59
35
開始ページ
3317
終了ページ
3321
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.tetlet.2018.07.044
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

pH-Responsive fluorescent pentamethine cyanine (Cy5) derivatives having nucleophilic substituents were synthesized. Cy5 derivatives 1-O having mercaptopropyl, hydroxypropyl, and aminopropyl groups on an indole nitrogen atom showed pH-dependent equilibria between a fluorescent open-ring structure (1-O) and a non-fluorescent closed-ring structure (1-C) in pH ranges 3-7, 6-7.5, and 8-9, respectively. pH-Responsive dyes 1a-C having a 1,3-thiazinane structure were easily internalized into A549 cells and converted to open-ring structure 1a-O in response to the relatively low pH of acidic compartments in the cells. (C) 2018 Elsevier Ltd. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.tetlet.2018.07.044
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000445299100004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.tetlet.2018.07.044
  • ISSN : 0040-4039
  • Web of Science ID : WOS:000445299100004

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