2003年7月
Rhodium-catalyzed cyclopropanation using ene-yne-imino ether compounds as precursors of (2-pyrrolyl)carbenoids
ORGANIC LETTERS
- ,
- ,
- ,
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- 巻
- 5
- 号
- 15
- 開始ページ
- 2615
- 終了ページ
- 2617
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1021/ol0347545
- 出版者・発行元
- AMER CHEMICAL SOC
[GRAPHICS]
The reaction of alkenes; with conjugated ene-yne-imino ether or ene-yne-aldimine in the presence of a catalytic amount of [Rh(OAC)(2)](2) gives (2-pyrrolyl)cyclopropanes in good yields. The key intermediate of this cyclopropanation is a (2-pyrrolyl)carbenoid generated by the nucleophilic attack of imine nitrogen atom at an internal alkyne carbon activated by rhodium complex. The intramolecular reaction also proceeds to afford a polycyclic pyrrole.
The reaction of alkenes; with conjugated ene-yne-imino ether or ene-yne-aldimine in the presence of a catalytic amount of [Rh(OAC)(2)](2) gives (2-pyrrolyl)cyclopropanes in good yields. The key intermediate of this cyclopropanation is a (2-pyrrolyl)carbenoid generated by the nucleophilic attack of imine nitrogen atom at an internal alkyne carbon activated by rhodium complex. The intramolecular reaction also proceeds to afford a polycyclic pyrrole.
- リンク情報
- ID情報
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- DOI : 10.1021/ol0347545
- ISSN : 1523-7060
- Web of Science ID : WOS:000184257600009