1992年11月
FUNCTIONAL INHIBITION OF HEMATOPOIETIC AND NEUROTROPHIC CYTOKINES BY BLOCKING THE INTERLEUKIN-6 SIGNAL TRANSDUCER GP130
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- 巻
- 89
- 号
- 22
- 開始ページ
- 10998
- 終了ページ
- 11001
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1073/pnas.89.22.10998
- 出版者・発行元
- NATL ACAD PRESS
Functional pleiotropy and redundancy are characteristic features of cytokines. To understand the signaling mechanisms of such cytokines, we have proposed a two-chain interleukin (IL) 6 receptor model: IL-6 triggers the association of a ligand-binding chain (IL-6 receptor) and a nonbinding signal transducer (gp130) to form a high-affinity receptor complex, resulting in transmission of the signal by the cytoplasmic portion of gp130. This model would explain the functional redundancy of cytokines if we were to assume that gp130 interacts with several different receptor chains. Here we present data indicating that gp130 functions as a common signal transducer for IL-6, oncostatin M, leukemia inhibitory factor, and ciliary neurotrophic factor. We show that anti-gp130 monoclonal antibodies completely block the biological responses induced by all of these factors. Since leukemia inhibitory factor functions as a cholinergic differentiation factor in nerve cells, as does ciliary neurotrophic factor, these results suggest that gp130 may also play a role in the nervous system.
- リンク情報
- ID情報
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- DOI : 10.1073/pnas.89.22.10998
- ISSN : 0027-8424
- Web of Science ID : WOS:A1992JY87400090