論文

査読有り
1991年7月

PREPARATION OF SOLUBLE MURINE IL-6 RECEPTOR AND ANTIMURINE IL-6 RECEPTOR ANTIBODIES

JOURNAL OF IMMUNOLOGY
  • T SAITO
  • K YASUKAWA
  • H SUZUKI
  • K FUTATSUGI
  • T FUKUNAGA
  • C YOKOMIZO
  • Y KOISHIHARA
  • H FUKUI
  • Y OHSUGI
  • H YAWATA
  • KOBAYASHI, I
  • T HIRANO
  • T TAGA
  • T KISHIMOTO
  • 全て表示

147
1
開始ページ
168
終了ページ
173
記述言語
英語
掲載種別
研究論文(学術雑誌)
出版者・発行元
AMER ASSOC IMMUNOLOGISTS

Starting with a previously isolated cDNA clone encoding murine IL-6R, a stable transformed Chinese hamster ovary cell line constitutively expressing soluble murine IL-6R (smIL-6R) has been established. The smIL-6R was purified to homogeneity by sequential filtration and chromatography of culture medium. The smIL-6R augmented the sensitivity of M1 cells to IL-6 in their growth inhibition in a dose-response manner. Rat hybridomas producing mAb specific to murine IL-6R were also established. One of the clones, RS13, produced IgG2a isotype that was capable of inhibiting IL-6 activity. ELISA for the quantitation of smIL-6R was established, which could detect smlL-6R in a quantity as low as 1 ng/ml.

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1991FT76300025&DestApp=WOS_CPL
ID情報
  • ISSN : 0022-1767
  • Web of Science ID : WOS:A1991FT76300025

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