1994年1月
ASSOCIATION OF TRANSCRIPTION FACTOR APRF AND PROTEIN-KINASE JAK1 WITH THE INTERLEUKIN-6 SIGNAL TRANSDUCER GP130
SCIENCE
- 巻
- 263
- 号
- 5143
- 開始ページ
- 89
- 終了ページ
- 92
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/science.8272872
- 出版者・発行元
- AMER ASSOC ADVANCEMENT SCIENCE
Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, interleukin-11, and ciliary neurotrophic factor bind to receptor complexes that share the signal transducer gp130. Upon binding, the ligands rapidly activate DNA binding of acute-phase response factor (APRF), a protein antigenically related to the p91 subunit of the interferon-stimulated gene factor-3alpha (ISGF-3alpha). These cytokines caused tyrosine phosphorylation of APRF and ISGF-3alpha p91. Protein kinases of the Jak family were also rapidly tyrosine phosphorylated, and both APRF and Jak1 associated with gp130. These data indicate that Jak family protein kinases may participate in IL-6 signaling and that APRF may be activated in a complex with gp130.
- リンク情報
- ID情報
-
- DOI : 10.1126/science.8272872
- ISSN : 0036-8075
- Web of Science ID : WOS:A1994MQ30100037