1998年5月
"Isogaba Maware": quality control of genome RNA by checkpoints
BIOESSAYS
- ,
- 巻
- 20
- 号
- 5
- 開始ページ
- 391
- 終了ページ
- 399
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1002/(SICI)1521-1878(199805)20:5<391::AID-BIES6>3.0.CO;2-R
- 出版者・発行元
- COMPANY OF BIOLOGISTS LTD
Checkpoints maintain the interdependency of cell cycle events by permitting the onset of an event only after the completion of the preceding event. The DNA replication checkpoint induces a cell cycle arrest until the completion of the DNA replication. Similarly, the DNA damage checkpoint arrests cell cycle progression if DNA repair is incomplete. A number of genes that play a role in the two checkpoints have been identified through genetic studies in yeasts, and their homologues have been found in fly, mouse, and human. They form signaling cascades activated by a DNA replication block or DNA damage and subsequently generate the negative constraints on cell cycle regulators. The failure of these signaling cascades results in producing offspring that carry mutations or that lack a portion of the genome. In humans, defects in the checkpoints are often associated with cancer-prone diseases. Focusing mainly on the studies in budding and fission yeasts, we summarize the recent progress. BioEssays 20:391-399, 1998. (C) 1998 John Wiley & Sons, Inc.
- リンク情報
- ID情報
-
- DOI : 10.1002/(SICI)1521-1878(199805)20:5<391::AID-BIES6>3.0.CO;2-R
- ISSN : 0265-9247
- Web of Science ID : WOS:000075208400006